a) Raw dynamic contrast-enhanced MR image on lesion, which exhibits high
signal intensity. The mass-like enhancement area is marked by purple arrow
and the lesion; (b) Raw Diffusion-weighted MR image (b = 800 s/mm2); (c)
Calculated ADC map from (b). Lesion area exhibits with light green (pointed
in purple arrow), implying a high ADC value. ADC measured in this lesion is
1.91×10−3 s/mm2. doi:10.1371/journal.pone.0087387.g002
a: Dynamic contrast MR demonstrates a breast lesion with rim enhancement. b:
Plateau (type 2) enhancement pattern. Signal intensity values were obtained from the
area of greatest enhancement. c: Spectroscopy detected no Cho signal (SNR 1.7) at 3.2
ppm in representative spectrum and magnified (50) region in the lesion. Histological
analysis of the tissue was benign breast tissue.(Fibroadenoma).
Proton MRI and MRSI in a 38-year-old patient (#7) with a fibroadenoma. a: Post-GdDTPA
T1-weighted MR image. b: MRSI of water, Cho, and lipids. c: Unmagnified spectra from the
lesion, demonstrating water and lipid peaks, and a weak Cho signal (SNR ! 4). d: Magnified
($50) spectrum from a voxel in the lesion demonstrating the weak Cho resonance.
A 37-year-old woman with fibroadenoma. Sagittal fat-saturated
postcontrast MRI image (a) shows a well-defined mass lesion with dark
internal septa, indicative of a fibroadenoma. MRS (b) shows a Cho peak at
3.28 ppm, possibly representing GPC, mI, and taurine instead of Cho and PC.
Cysts are fluid-filled, round or ovoid structures that are
found in as many as one third of women between 35 and 50
years old. Although most are subclinical “microcysts,” in about
20%–25% of cases, palpable (gross) cystic change, which
generally presents as a simple cyst, is encountered . Cysts
cannot reliably be distinguished from solid masses by clinical
breast examination or mammography; in these cases,
ultrasonography and fine needle aspiration (FNA) cytology,
which are highly accurate, are used.
Cysts are derived from the terminal duct lobular unit. In most
cysts, the epithelial lining is either flattened or totally absent.
In only a small number of cysts, an apocrine epithelial lining is
observed. Because gross cysts are not associated with an
increased risk of carcinoma development, the current
consensus on the management of gross cysts is routine follow-
up of the patient, without further therapy.