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Integriculture Inc., Cellular Agriculture Initiative

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Deck for Integriculture Inc. - commercialization of clean meat and cellular agriculture products, starting from cosmetics and supplements, ingredients then to food

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Integriculture Inc., Cellular Agriculture Initiative

  1. 1. Integriculture Inc. Cell-Ag Initiative
  2. 2. Cell culture cost 1/10000 Cell- based meat PCT/JP2016/067599 JP-Pat.6111510
  3. 3. Cell-based meat 3 Muscle cells Bioreactor Culture medium Processing Cell-based chicken liver paste
  4. 4. Seafood $200B $2 Trillion (2020)* Beef $800B 10x resource intensive > soy 70% of deforestation 18% of GHG emissions Footprints Animal Agriculture (And Its Environmental Cost) Is Growing 4*Zion Market Research
  5. 5. The mounting food security crisis 5 *Reuters (2017) **Nikkei (2017) “Alternative protein sources are necessary. Consider algae and insect as options.” Signed to invest $300M to Israeli alternative protein startups. Trading companies priced out to other countries importing beef.
  6. 6. Land use -98%, Water use -95%? Near zero food miles Algal production of culture media Meat cell culture Tuomisto (2011)
  7. 7. Cellular Agriculture Production of agricultural products by cell culture
  8. 8. The technological problem €250,000 Clean meat burger, 200g
  9. 9. ~2016 Conventional $2 Growth factors Consumables CapEx Serum-free 2017 Lab scale 2026 large scale plant ”Culnet System” : General purpose large-scale cell culture Cells [A] Cells [B] Dialysis,oxygenationetc. Musclecells PCT/JP2016/067599 Japan Pat.6111510 Cell culture cost 1/10000 $600K/kg $2K
  10. 10. No externally added FBS & growth factors * * “Culnet System” grows variety of cells without added growth factors Liver cells Muscle stem cell Placental cells Conventional“CulnetSystem” ”Culnet System" Cellcount(ratio) □Liver cells ■Pancreas cells ■Ovary cells *p<0.01, **p<0.05
  11. 11. Amnion Liver Oviduct (adult chicken) Intestine Brain Gallbladder Pancreas Muscle Versatility: tested cell types
  12. 12. “Culnet System” at a glacne “General-purpose large-scale cell culture system” The technology to inexpensively produce wide range of cells Currently at > 1/100, > 1/100,000 within sight by economy of scale
  13. 13. ✅Not limited to muscle ✅No added growth factors ✅Scalable(Flow-based) “Culnet System” proof of concept Cell-based chicken liver paste Proof of Concept No.1 & 2
  14. 14. Enzymes Nucleic acids Sugars Lipids Extracellular matrix Organ cells Cellular proteins Cellular metabolites Products of the “Culnet System” Culture medium Cell mass Acellular products Cellular products
  15. 15. “Cell-ag infrastructure” Sugar & amino acid “Culnet System” infrastructure Cells ingredients supplements foie gras meat etc. High Low Unit price Unit price
  16. 16. 16 Cosmetics market “Early adopters” ✅Contamination free ✅Animal cruelty free ✅Stable supply ✅Can use human cells ✅Already gaining traction Youth Elderly High-end Low-end $1.5B market capitalization (Japan) “Customizable Cellular Cosmetics” EGF HGF VEGF etc.
  17. 17. 2020 2023 2026 100kg/mon. 3~100t /month 300t/day Cell-ag plant 120,000 1,200 1.2 Annual volume(tn) 〰〰〰 〰〰〰 〰〰〰 〰〰〰 Product roadmap: Volume & price projection Ingredients, Bio-reagents Cosmetics, supplements Supplements, food
  18. 18. Series A (12~15M) 2019/11 Seed($3M) Closed on 2018/04/25 Cell culture: $600M (Japan, 2015, Fuji Keizai) Skincare:$115B (Japan, 2017, Yano Keizai) Global protein:$2T (2013 Rabobank) Product development Market & financial projections Cosmetics⇒Supplements⇒Food
  19. 19. Partnerships Cells, Bio-reagents and functional compounds Product development, S&D Supplements and food Mid-term joint R&D Cellular agriculture plants R&D, construction, operation
  20. 20. Meat by cellular agriculture One of many possibilities Large scale suspension culture in a bioreactor Fat cell coculture Immunity cell culture Growth factor source (liver cells) Myoblasts bioreactor Cell cluster suspension culture, further scalable
  21. 21. Seafood by cellular agriculture
  22. 22. Food production on Mars
  23. 23. Orbital Cell-Ag Facility

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