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CV Yuanlu Shi 201609 CN&EN


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CV Yuanlu Shi 201609 CN&EN

  1. 1. Curriculum Vitae Yuanlu Shi Correspondence address Yuanlu Shi, PhD Shanghai, P.R. China Email: Mobile: +86 13811180774 Work Experience 2016.08 Project Coordinator, Shanghai Maternal and Child Health Center, Shanghai, P.R. China Function as team player in following projects: • Plan the epidemiological research on sexually Transmitted Infection among adolescents in Shanghai • Write Public Health Service Standards and Guidance for health care during menopause • literature retrieval on child obesity • Translate bulletins from WHO Education 2011-2015 Ph. D in Food Chemistry and Biochemistry School of Food Science and Nutrition, University of Leeds, UK China Scholarship Council - University of Leeds Scholarship, Thesis title: Effects of Quercetin on Uric Acid Metabolism 2007-2011 B. Sc. in Biological Sciences, School of Biology, China Agricultural University, P.R.China Research Expertises 3 years of working experience in conducting clinical trials. 6 years of rich experience in analytical biochemistry. Research and Development in functional foods against potential diabetes, obesity, cardiovascular disease, gout, ageing and cancer. Expertises in chemical analysis using chromatography (HPLC-DAD, -MS), NMR and spectrophotometry, as well as statistical analysis tools. Metabolic pathways of physico-chemicaleffect of polyphenols. Research Experience Human study A: In vivo efficiency of delivery of supplement tablets comparing to natural food. (Publication DOI: 10.1039/C5FO00155B) Human study B: In vivo effects of dietary supplement (Publication DOI:10.1017/S0007114515005310) Hypothesis and study design Ethical review Recruitment and participant follow up Clinical sampling, processing and management (plasma and urine) Biochemical analysis Spectrophotometric analysis of plasma metabolites, e.g. urate, glucose Compounds separation, identification and quantification using HPLC-MS of polyphenols in foods, purine metabolites in plasma and polyphenol conjugates in urine. 1 H NMR metabolomic profiling of blood plasma
  2. 2. Sample preparation and data acquisition Chemometric analysis Publications Shi, Y., Fisher J. and Williamson G.(pending submission) ‘Supplementation of quercetin showed distinct metabolic profile of plasma in healthy males as assessed by a 1 H NMR-based metabolomic approach: a randomised, double-blinded, placebo-controlled, cross-over trial’ Shi, Y., Williamson, G., (2016) ‘Quercetin lowers plasma uric acid in pre-hyperuricaemic males: a randomised, double-blinded, placebo-controlled, cross-over trial’, British Journal of Nutrition, British Journal of Nutrition 2016,115(5):800-6, DOI:10.1017/S0007114515005310 ( ID: NCT01881919) Shi, Y., Williamson, G., (2015) ‘Comparison of the urinary excretion of quercetin glycosides from red onion and aglycone from dietary supplements in healthy subjects: a randomized, single-blinded, cross-over study’, Food and Function 2015,6(5):1443-8, DOI:10.1039/C5FO00155B Shi, Y. as guest speaker in 1st Food Science and Nutrition Postgraduate Research Conference, 2014, University of Leeds, UK. Equipment and Computer Proficiency Data/Statistical Analysis:SPSS (IBM), SIMCA-P+ (Umetrics), Excel (MS office) Data Visualization:OriginPro (OriginLab), PowerPoint (MS office), CorelDRAW (Corel Co.) Scientific Communication:Endnote (Reuters), Word (MS office) HPLC (Agilent Technologies) LC-MS (Shimadzu), Labsolutions (Shimadzu) NMR: Varian Unity Inova 500 MHz NMR, ACD/NMR Processor (ACD labs) Other Skills and Trainings Venepuncture, trained by Leeds Metropolitan University, 2012 First aid, trained by occupational health service, U. of Leeds, 2013-2016 Safety of gas cylinders usage, trained by Gas Safe Consultants, Ltd., 2013-2015 Laboratory Services Line Manager of HPLC equipment and drying line Routine check on equipment performance and maintenance Training colleagues and visiting researchers on basic usage Generate formal instructions and troubleshooting manuals Technical advice on equipment parameters according to research needs Management of booking systems On call assistance of all emergency situations Drying line includes spinning evaporator, freeze dryer, and nitrogen gas dryer and oven dryer. Gas supplying and loading for nitrogen dryer (N2), Cell culture (CO2) and -80 ̊C storage (liquid CO2) Laboratory Demonstrator /Seminar Teacher in Following Modules FOOD5405 Professional Development for Employment and Research (PG) FOOD2031 Molecules Controlling Sensory and Nutritional Properties (UG) FOOD2190 Food Quality and New Product Development (UG)