Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.

Nanopore Sequencing 2019 - Patent Landscape Analysis - KnowMade

114 views

Published on

With the coming launch of new products for various technologies, which companies will lead the nanopore sequencing IP landscape?

More information on: https://www.i-micronews.com/products/nanopore-sequencing-2019-patent-landscape-analysis/

Published in: Technology
  • This already saved me $120 on a car battery! When my car battery died, I decided to try out the EZ Battery Reconditioning method instead of buying a new (expensive) battery. And in just 25 minutes, I reconditioned the battery and it works fantastic again! This already saved me $120 on a car battery! I can�t wait to try this on other batteries now. ★★★ http://t.cn/AiFAb0DL
       Reply 
    Are you sure you want to  Yes  No
    Your message goes here
  • Be the first to like this

Nanopore Sequencing 2019 - Patent Landscape Analysis - KnowMade

  1. 1. Picture: Joseluissc3 © 2019 | www.knowmade.com KnowMadePatent & Technology Intelligence From Patents to Business Intelligence Nanopore Sequencing Patent Landscape Analysis February 2019
  2. 2. 2 © 2019 All rights reserved | www.knowmade.com Nanopore Sequencing – Patent Landscape Analysis | February 2019 | Ref. : KM19002 TABLE OF CONTENTS INTRODUCTION 5 - Nanopore sequencing - Scope of the report - Key features of the report - Objectives of the report - Related reports METHODOLOGY 13 - Patent search, selection and analysis - Search strategy - Key patent identification - Terminologies for patent analysis MAIN ASSIGNEES MENTIONED 24 EXECUTIVE SUMMARY 31 PATENT LANDSCAPE OVERVIEW 36 - Time evolution of patent publications - Countries of patent filings - Time evolution by country of filing - Ranking of most prolific patent applicants - Mapping of main current IP holders - Mapping of main current IP applicants IP POSITION OF MAIN PATENT ASSIGNEES 43 - Strength index of patent portfolios - Patent citation analysis - IP blocking potential of patent applicants - Time evolution for main patent applicants - Countries of filings for main patent applicants - Summary of applicant’s patent portfolios - Patent applicants IP network - IP leadership of patent applicants - Granted patents near expiration - Degree of specialization - Potential future plaintiffs ANALYSIS BY TECHNOLOGY 66 - Technical Segmentation by Technology - Main Assignees by Technology - Time Evolution by Technology - Time Evolution by Country - Legal Status by Technology - Conclusion ANALYSIS BY APPLICATION 83 - Technical Segmentation by Application - Main Assignees by Application - Time Evolution by Application - Legal Status by Application - Conclusion MAIN PATENT LITIGATIONS 97 - Illumina vs Oxford Nanopore Technologies - Pacific Biosciences vs Oxford Nanopore Technologies - University of California vs Roger Chen and Genia Technologies IP PROFILE OF KEY PLAYERS 102 - Harvard University - University of California - Chinese University of Hong Kong - Oxford Nanopore Technologies - Roche - Nabsys - Two Pore Guys - Quantapore - Hitachi - Illumina - Pacific Biosciences of California - Sequenom - Agilent Technologies - Thermo Fisher Scientific For each selected player: - Company profile and news - Summary of the patent portfolio - Key patents families OTHER KEY PATENTS 164 CONCLUSION 174 KNOWMADE PRESENTATION 182
  3. 3. 3 © 2019 All rights reserved | www.knowmade.com Nanopore Sequencing – Patent Landscape Analysis | February 2019 | Ref. : KM19002 THE AUTHORS Specialized in analysis of patents and scientific information, Knowmade provides Technology Intelligence and IP strategy consulting services. The company is supporting R&D organizations, industrial companies and investors in their business development by offering them a deep understanding of the technology trends and their IP environment. Knowmade operates in the following industrial sectors: Microelectronics, Compound Semiconductors, Power Electronics, RF & Microwave Devices, MEMS Sensors & Actuators, LED/OLED, Imaging & Display, Photonics, Battery, Manufacturing & Advanced Packaging, Micro & Nanotechnology, Biotechnology, Cellular & Molecular Biology, Microbiology, Dermatology, Pharmacology, Oncology, Immunology, Medical Devices & Medical Imaging, Agri- Food & Environment. Knowmade performs prior art search, patent landscape analysis, scientific literature analysis, patent valuation and freedom-to-operate analysis. In parallel, the company proposes litigation/licensing support, technology scouting and IP watch service. Knowmade’s analysts combine their technical and patent expertise by using powerful analytics tools and proprietary methodologies to deliver relevant patent analyses and scientific reviews. We Know Technology, We Know Patents Dr. Brice Sagot CTO and co-founder of Knowmade. He leads the Biotechnology and Life Sciences department. He holds a PhD in Molecular Biology from the University of Nice Sophia-Antipolis (France). Contact: brice.sagot@knowmade.fr Olivier Thomas Olivier works at Knowmade in the field of Biotechnology and Life Sciences. He holds a MSc in Molecular and Cellular Biology from the UPMC (Paris, France). He also holds the Industrial Property International Studies Diploma in Patents and Trademarks from the CEIPI (Strasbourg, France). Contact: olivier.thomas@knowmade.fr
  4. 4. 4 © 2019 All rights reserved | www.knowmade.com Nanopore Sequencing – Patent Landscape Analysis | February 2019 | Ref. : KM19002 INTRODUCTION Scope of the Report • This report provides a detailed picture of the patent landscape for nanopore sequencing. • This report covers patents published worldwide up to August 2018. • We have selected and analyzed about 1,600 patent families relevant to the scope of this report. Included in the report Not included in the report  Patents related to nanopore sequencing  Patents related to the three main nanopore sequencing modalities:  Protein nanopores  Solid-state nanopores  Hybrid nanopores  Patents related to various applications nanopore sequencing can be used for, such as:  infectiology  oncology  prenatal diagnostics ꓫ Patents only dedicated to other sequencing methods ꓫ Patents about nanopores not claiming or mentioning a sequencing application WO2017/106481 US2018/0037948
  5. 5. 5 © 2019 All rights reserved | www.knowmade.com Nanopore Sequencing – Patent Landscape Analysis | February 2019 | Ref. : KM19002 INTRODUCTION Key Features of the report • The report provides essential patent data about nanopore sequencing. • It provides in-depth patent analyses of key technologies and key players including: – Time evolution of patent publications and countries of patent filings. – Current legal status of patents. – Ranking of main patent applicants. – Joint developments and IP collaboration network of main patent applicants. – Key patents. – Relative strength of main companies IP portfolio. – Matrix patent applicants/technology issues for main IP players. • The IP profiles of 20 key players is presented, including key patents, technological issues, partnerships, IP strength: Oxford Nanopore Technologies, Agilent Technologies, Pacific Biosciences of California, Illumina, Harvard University, University of California, etc.
  6. 6. 6 © 2019 All rights reserved | www.knowmade.com Nanopore Sequencing – Patent Landscape Analysis | February 2019 | Ref. : KM19002 INTRODUCTION Key Features of the report • The report also provides an extensive Excel database with all patents analyzed in the report. • This patent database allows multi-criteria searches, including: - Patent publication number - Hyperlinks to the original documents - Priority date - Title - Abstract - Patent assignees - Technical segmentation - Legal status for each member of the patent family • This report does not provide any insight analyses or counsel regarding legal aspects or the validity of any individual patent. Knowmade is a research firm that provides technical analysis and technical opinions. Knowmade is not a law firm. The research, technical analysis and/or work proposed or provided by Knowmade and contained herein is not a legal opinion and should not be construed as such.
  7. 7. 7 © 2019 All rights reserved | www.knowmade.com Nanopore Sequencing – Patent Landscape Analysis | February 2019 | Ref. : KM19002 Patent Landscape Overview Patent assignees, IP dynamics, patent legal status, patent geographical coverage
  8. 8. 8 © 2019 All rights reserved | www.knowmade.com Nanopore Sequencing – Patent Landscape Analysis | February 2019 | Ref. : KM19002 Patent Portfolios Benchmarking: Beyond the Quantity Who has the best patent portfolio?
  9. 9. 9 © 2019 All rights reserved | www.knowmade.com Nanopore Sequencing – Patent Landscape Analysis | February 2019 | Ref. : KM19002 Patent Segmentation What are the key IP players per nanopore technology?
  10. 10. 10 © 2019 All rights reserved | www.knowmade.com Nanopore Sequencing – Patent Landscape Analysis | February 2019 | Ref. : KM19002 Patent Segmentation What are the key IP players per application?
  11. 11. 11 © 2019 All rights reserved | www.knowmade.com Nanopore Sequencing – Patent Landscape Analysis | February 2019 | Ref. : KM19002 Key elements summary Key IP players, key patents
  12. 12. 12 © 2019 All rights reserved | www.knowmade.com Nanopore Sequencing – Patent Landscape Analysis | February 2019 | Ref. : KM19002 Excel file with all patents analyzed in the report Useful patent database allows multi-criteria searches Patent information ApplicationsTechnologies
  13. 13. 13Nanopore Sequencing – Patent Landscape Analysis | February 2019 | Ref. : KM19002 © 2019 All rights reserved | www.knowmade.com Related reports You may also be interested in those market analysis reports of our partner Yole Développement: You may also be interested in those teardown & costing analysis reports of our partner System Plus Consulting:
  14. 14. Time Evolution of Patent Publications Patent Landscape Analysis Nanopore Sequencing Patent Landscape Analysis, February 2019 With the coming launch of new products for various technologies, which companies will lead the nanopore sequencing IP landscape? REPORT OUTLINE • Nanopore sequencing • Patent landscape analysis • February 2019 • Ref.: KM19002 • PDF >170 slides • Excel file >7,200 patents • €6,490 for a multi-user license REPORT’S KEY FEATURES: • IP trends, including time-evolution of published patents, and countries of patent filings • Patents’ current legal status • Ranking of main patent assignees • Key players’ IP position and relative strength of their patent portfolios • IP analysis of nanopore technologies (solid-state nanopores, protein nanopores, and hybrid nanopores) and IP analysis of applications (oncology, plant genetics, infectiology, etc.) • Main patent litigations • Description of key players and key patents • Excel database with all patents analyzed in this report, including technology segmentation LINKED REPORTS • CRISPR Technology & Market Overview: from Lab to Industry 2018 • Liquid Biopsy: From Isolation to Downstream Applications 2018 • Thermo Fisher - Ion 520 DNA Sequencing Chip Nanopore sequencing is a promising technology in the field of next- generation sequencing The analysis of the time-evolution of patent publications shows an important increase in nanopore sequencing-related patenting activity from 2008 - 2013. This increase follows the work of academic research teams (Harvard University and University of California) that proved the concept of nanopore sequencing. Even though the industrial players developing nanopore-based sequencing are steadily gaining importance, Harvard’s patent portfolio remains the strongest, followed by Illumina, Agilent, University of California, and Roche, whose influence in the IP landscape is growing. In fact, Roche is now the most prolific applicant in nanopore sequencing. Contrarily, Oxford Nanopore Technologies’ patent portfolio is not the strongest, but the company benefits from the numerous partnerships it has with universities (Harvard, University of California, and Boston University). Moreover, several companies with strong experience in microelectronics and semiconductors (Hitachi, IBM, Samsung Electronics, Intel, and GlobalFoundries) have recently filed patents claiming solid-state nanopores. Most main patent assignees have developed an international IP strategy. American players have a strong presence in the US and Europe. Some European companies are also well ranked, and a few Asian firms play a significant role in the patent protection of nanopore sequencing. Nanopore sequencing is one of the next-generation sequencing (NGS) technologies believed to be capable of revolutionizing DNA analysis. Different modalities of nanopore sequencing have been developed over time, including protein nanopores, solid-state nanopores, and hybrid nanopores. The technology enables production of ultra-long reads at very high speeds, reducing sample preparation time as well as the data-processing time required to reassemble the reads into their original sequence. This novel technology could tap into a brand-new sector of customers who may require genetic fingerprinting for fast identification of cancer types and pathogens. According to DataBridge, the global NGS market will grow fast, from $US 4.83B in 2017 to $US 16.35B in 2024, at an estimated compound annual growth rate (CAGR) of 19.2% (from 2018 - 2024). Today, Oxford Nanopore Technologies is the only company to have brought nanopore- based sequencers to market. However, several other companies are developing their own technology, and Oxford Nanopore may not be the only supplier of nanopore-based sequencers much longer. For example, Two Pore Guys has announced the release of its product suite in spring 2019. With new products launching in the near future, it is crucial to understand the intellectual property (IP) position and strategy of established nanopore sequencing players, while identifying the IP newcomers and the threat they represent. To this end, Knowmade has identified the key IP players involved in nanopore-based sequencing technologies (protein, solid-state, and hybrid) and their applications (oncology, plant genetics, etc.). Such knowledge can help detect business risks and opportunities, anticipate emerging applications, and enable strategic decisions to strengthen one’s market position. © Knowmade 2019 Distributed by
  15. 15. Analyzing patents for each main nanopore technology and application Nanopore Sequencing - Patent Landscape Analysis – February 2019 Patents are categorized by nanopore technology (protein, solid-state, and hybrid) and by main application. Also, IP trends and the relative strength of each main patent assignee was analyzed. These findings reveal that solid-state nanopore-related patents are more numerous than those related to protein nanopore or hybrid nanopore. From an IP perspective, Roche leads for technologies related to protein nanopore, and Oxford Nanopore Technologies leads the solid-state nanopore and hybrid nanopore segments. Regarding applications, the main patented application for nanopore sequencing is oncology. Plant genetics, epigenetics, and transcriptomics are also important application domains for nanopore sequencing. Among the main applications for nanopore sequencing, microbiome analysis is the most recent, but already a few companies are positioned in this segment. This report also includes an Excel database containing the >7,200 patents analyzed in this study. This useful database allows for multi-criteria searches and includes patent publication numbers, hyperlinks to original documents, priority date, title, abstract, patent assignees, and each patent’s current legal status, as well as nanopore technologies and applications. Main Assignees, by Application KnowMade’s study includes IP profiles for key players and a description of their key patents. The key-patent analysis includes the legal state of the family for each of the main territories, the number of received citations, the review of main claims, the description of interesting features disclosed about the innovation, and relevant figures illustrating how the innovation works. This section also covers patents involved in litigations. Key Patent Analysis IP profile of main players, and analysis of their key patents
  16. 16. TABLE OF CONTENTS ABOUT KNOWMADE Specialized in the analysis of patents and scientific information, Knowmade provides technology intelligence and IP strategy consulting services. The company supports the business development of R&D organizations, industrial companies, and investors by offering them a deep understanding of their IP environment and technology trends. Knowmade operates in the following industrial sectors: compound semiconductors, power electronics, RF devices and technologies, solid-state lighting and display, photonics, memory, MEMS and sensors, semiconductor manufacturing and advanced packaging, battery and energy management, biotechnology, pharmaceuticals, medical devices, medical imaging, and agri-food. Knowmade’s experts provide prior-art search, patent landscape analysis, scientific literature analysis, patent valuation, IP due diligence, and freedom-to-operate analysis. The company also delivers litigation/licensing support, technology scouting, and IP/technology observation. Knowmade’s analysts combine their technical and patent expertise with powerful analytics tools and proprietary methodologies, delivering invaluable patent analyses and scientific reviews. Olivier THOMAS Olivier works at Knowmade in the field of Biotechnology and Life Sciences. He holds a MSc in Molecular and Cellular Biology from the UPMC (Paris, France). He also holds the Industrial Property International Studies Diploma in Patents and Trademarks from the CEIPI (Strasbourg, France). Contact: olivier.thomas@knowmade.fr Dr. Brice SAGOT CTO and co-founder of Knowmade, Brice leads the Biotechnology and Life Sciences department. He holds a PhD in Molecular Biology from the University of Nice Sophia- Antipolis (France). Contact: brice.sagot@knowmade.fr AUTHORS COMPANIES MENTIONED IN THIS REPORT (NON-EXHAUSTIVE LIST) OXFORD NANOPORE TECHNOLOGIES, ROCHE, ILLUMINA, PACIFIC BIOSCIENCES OF CALIFORNIA, QUANTAPORE, ELECTRONIC BIOSCIENCE, STRATOS GENOMICS, TWO PORE GUYS, HITACHI, AGILENT TECHNOLOGIES, THERMO FISHER SCIENTIFIC, SEQUENOM, INTEL, IBM, GLOBALFOUNDRIES, ABBOTT, BECTON DICKINSON, BGI, NUGEN TECHNOLOGIES, QUANTUM BIOSYSTEMS, SAMSUNG, BIO RAD, LUX BIO, TWIST BIOSCIENCE, 10X GENOMICS, CARIS LIFE SCIENCES, QUANTUMDX, DOVETAIL GENOMICS, CELEMICS, GRAIL, GATC BIOTECH, ARIMA GENOMICS, EXCILONE, TWINSTRAND BIOSCIENCES, and more Nanopore Sequencing - Patent Landscape Analysis – February 2019 INTRODUCTION 5 METHODOLOGY 13 MAIN ASSIGNEES MENTIONED 24 EXECUTIVE SUMMARY 31 PATENT LANDSCAPE OVERVIEW 36 - Time evolution of patent publications - Countries of patent filings - Time evolution, by country of filing - Ranking of most prolific patent applicants - Mapping of main current IP holders - Mapping of main current IP applicants MAIN PATENT ASSIGNEES ANALYSIS 43 - Strength index of patent portfolios - Patent citation analysis - IP blocking potential of patent applicants - Time evolution for main patent applicants - Countries of filing for main patent applicants - Summary of applicant’s portfolios - Patent applicants IP network - IP leadership of patent applicants - Granted patents nearing expiration - Degree of specialization - Potential future plaintiffs ANALYSIS, BY TECHNOLOGY 66 - Technical segmentation, by technology - Main assignees, by technology - Time evolution, by technology - Time evolution, by country - Legal status, by technology ANALYSIS, BY APPLICATION 82 - Technical segmentation, by application - Main assignees, by application - Time evolution, by application - Legal status, by application MAIN PATENT LITIGATIONS 96 - Illumina vs. Oxford Nanopore Technologies - Pacific Biosciences vs. Oxford Nanopore Technologies - University of California vs. Roger Chen and Genia Technologies IP PROFILE FOR KEY PLAYERS 101 - Harvard University - University of California - Chinese University of Hong Kong - Oxford Nanopore Technologies - Roche - Nabsys - Two Pore Guys - Quantapore - Hitachi - Illumina - Pacific Biosciences of California - Sequenom - Agilent Technologies - Thermo Fisher Scientific For each selected player: - Company profile and news - Summary of their patent portfolio - Key patent families OTHER KEY PATENTS 163 CONCLUSION 173 KNOWMADE PRESENTATION 180
  17. 17. BILL TO Name (Mr/Ms/Dr/Pr): ______________________________________ Job Title: ______________________________________ Company: ______________________________________ Address: ______________________________________ City: ______________________________________ State: ______________________________________ Postcode/Zip: ______________________________________ Country: ______________________________________ VAT ID Number for EU members: ______________________________________ Tel: ______________________________________ Email: ______________________________________ Date: ______________________________________ Signature : I hereby accept Yole’s Terms and Conditions of Sale (1) ...................................................................................... (1) Our Terms and Conditions of Sale are available on www.yole.fr/pagesAn/company/conditions.aspx ORDER FORM Nanopore Sequencing Patent Landscape Analysis, February 2019 Ref.: KM19002 PAYMENT CREDIT CARD: Name of the Card Holder: Credit Card Number: Card Verification Value (3 last digits except AMEX: 4 last digits) : Expiration date: BY BANK TRANSFER: BANK INFO: HSBC, 1 place de la Bourse, F-69002 Lyon, France, Bank code : 30056, Branch code : 00170 Account No : 0170 200 1565 87, SWIFT or BIC code : CCFRFRPP, IBAN : FR76 3005 6001 7001 7020 0156 587 RETURN ORDER BY: • FAX: +33 (0)472 83 01 83 • MAIL: YOLE DEVELOPPEMENT, Le Quartz,75 cours Emile Zola, 69100 Villeurbanne, France CONTACT: • Japan: Miho - Ohtake@yole.fr • Greater China: Mavis - Wang@yole.fr • Asia: Takashi - Onozawa@yole.fr • EMEA: Lizzie - Levenez@yole.fr • North America: Steve – laferriere@yole.fr • General: info@yole.fr The present document is valid till February 13th, 2020 Visa Mastercard Amex  in One User License EUR 5,990*  in Multi Users License EUR 6,490* *For price in dollars please use the day’s exchange rate . All reports are delivered electronically. For French customer, add 20 % for VAT SHIP TO ABOUT YOLE DEVELOPPEMENT First Name: .................................................................. Last Name: ............................................................................ Email:............................................................................ Phone:..................................................................................... Founded in 1998, Yole Développement has grown to become a group of companies providing marketing, technology and strategy consulting, media and corporate finance services. With a strong focus on emerging applications using silicon and/or micro manufacturing, the Yole Développement group has expanded to include more than 50 collaborators worldwide covering MEMS, Compound Semiconductors, LED, Image Sensors, Optoelectronics, Microfluidics & Medical, Advanced Packaging, Manufacturing, Nanomaterials, Power Electronics and Batteries & Energy Management. The “More than Moore” company Yole, along with its partners System Plus Consulting, Blumorpho and KnowMade, support industrial companies, investors and R&D organizations worldwide to help them understand markets and follow technology trends to grow their business. CUSTOM STUDIES • Market data & research, marketing analysis • Technology analysis • Reverse engineering & costing services • Strategy consulting • Patent analysis More information on www.yole.fr MEDIA • i-Micronews.com, online disruptive technologies website and its weekly e-newsletter, @Micronews • Communication & webcasts services • Events: Yole Seminars, Market Briefings More information on http://www.i-micronews.com/media-kit.html TECHNOLOGY & MARKET REPORTS • Collection of technology & market reports • Manufacturing cost simulation tools • Component reverse engineering & costing analysis • Patent investigation More information on http://www.i-micronews.com/reports.html Distributed by
  18. 18. TERMS AND CONDITIONS OF SALES . Definitions: “Acceptance”: Action by which the Buyer accepts the terms and conditions of sale in their entirety. It is done by signing the purchase order which mentions “I hereby accept Yole’s Terms and Conditions of Sale”. “Buyer”: Any business user (i.e. any person acting in the course of its business activities, for its business needs) entering into the following general conditions to the exclusion of consumers acting in their personal interests. “Contracting Parties” or “Parties”: The Seller on the one hand and the Buyer on the other hand. “Intellectual Property Rights” (“IPR”) means any rights held by the Seller in its Products, including any patents, trademarks, registered models, designs, copyrights, inventions, commercial secrets and know-how, technical information, company or trading names and any other intellectual property rights or similar in any part of the world, notwithstanding the fact that they have been registered or not and including any pending registration of one of the above mentioned rights. “License”: For the reports and databases, 3 different licenses are proposed. The buyer has to choose one license: • One user license: one person at the company can use the report. • Multi-user license: the report can be used by unlimited users within the company. Subsidiaries and Joint-Ventures are not included. • Corporate license: purchased under “Annual Subscription” program, the report can be used by unlimited users within the company. Joint-Ventures are not included. “Products”: Depending on the purchase order, reports or database on MEMS, CSC, Optics/MOEMS, Nano, bio… to be bought either on a unit basis or as an annual subscription. (i.e. subscription for a period of 12 calendar months). The annual subscription to a package (i.e. a global discount based on the number of reports that the Buyer orders or accesses via the service, a global search service on line on I-micronews and a consulting approach), is defined in the order. Reports are established in PowerPoint and delivered on a PDF format and the database may include Excel files. “Seller”: Based in Lyon (France headquarters), Yole Développement is a market research and business development consultancy company, facilitating market access for advanced technology industrial projects. With more than 20 market analysts, Yole works worldwide with the key industrial companies, R&D institutes and investors to help them understand the markets and technology trends. 1. Scope 1.1 The Contracting Parties undertake to observe the following general conditions when agreed by the Buyer and the Seller. ANY ADDITIONAL, DIFFERENT, OR CONFLICTING TERMS AND CONDITIONS IN ANY OTHER DOCUMENTS ISSUED BY THE BUYER AT ANY TIME ARE HEREBY OBJECTED TO BY THE SELLER, SHALL BE WHOLLY INAPPLICABLE TO ANY SALE MADE HEREUNDER AND SHALL NOT BE BINDING IN ANY WAY ON THE SELLER. 1.2 This agreement becomes valid and enforceable between the Contracting Parties after clear and non-equivocal consent by any duly authorized person representing the Buyer. For these purposes, the Buyer accepts these conditions of sales when signing the purchase order which mentions “I hereby accept Yole’s Terms and Conditions of Sale”. This results in acceptance by the Buyer. 1.3 Orders are deemed to be accepted only upon written acceptance and confirmation by the Seller, within [7 days] from the date of order, to be sent either by email or to the Buyer’s address. In the absence of any confirmation in writing, orders shall be deemed to have been accepted. 2. Mailing of the Products 2.1 Products are sent by email to the Buyer: - within [1] month from the order for Products already released; or - within a reasonable time for Products ordered prior to their effective release. In this case, the Seller shall use its best endeavours to inform the Buyer of an indicative release date and the evolution of the work in progress. 2.2 Some weeks prior to the release date the Seller can propose a pre-release discount to the Buyer The Seller shall by no means be responsible for any delay in respect of article 2.2 above, and including incases where a new event or access to new contradictory information would require for the analyst extra time to compute or compare the data in order to enable the Seller to deliver a high quality Products. 2.3 The mailing of the Product will occur only upon payment by the Buyer, in accordance with the conditions contained in article 3. 2.4. The mailing is operated through electronic means either by email via the sales department or automatically online via an email/password. If the Product’s electronic delivery format is defective, the Seller undertakes to replace it at no charge to the Buyer provided that it is informed of the defective formatting within 90 days from the date of the original download or receipt of the Product. 2.5 The person receiving the Products on behalf of the Buyer shall immediately verify the quality of the Products and their conformity to the order. Any claim for apparent defects or for non-conformity shall be sent in writing to the Seller within 8 days of receipt of the Products. For this purpose, the Buyer agrees to produce sufficient evidence of such defects. . 2.6 No return of Products shall be accepted without prior information to the Seller, even in case of delayed delivery. Any Product returned to the Seller without providing prior information to the Seller as required under article 2.5 shall remain at the Buyer’s risk. 3. Price, invoicing and payment 3.1 Prices are given in the orders corresponding to each Product sold on a unit basis or corresponding to annual subscriptions. They are expressed to be inclusive of all taxes. The prices may be reevaluated from time to time. The effective price is deemed to be the one applicable at the time of the order. 3.2 Yole may offer a pre release discount for the companies willing to acquire in the future the specific report and agreeing on the fact that the report may be release later than the anticipated release date. In exchange to this uncertainty, the company will get a discount that can vary from 15% to 10%. 3.3 Payments due by the Buyer shall be sent by cheque payable to Yole Développement, credit card or by electronic transfer to the following account: HSBC, 1 place de la Bourse 69002 Lyon France Bank code: 30056 Branch code: 00170 Account n°: 0170 200 1565 87 BIC or SWIFT code: CCFRFRPP IBAN: FR76 3005 6001 7001 7020 0156 587 To ensure the payments, the Seller reserves the right to request down payments from the Buyer. In this case, the need of down payments will be mentioned on the order. 3.4 Payment is due by the Buyer to the Seller within 30 days from invoice date, except in the case of a particular written agreement. If the Buyer fails to pay within this time and fails to contact the Seller, the latter shall be entitled to invoice interest in arrears based on the annual rate Refi of the «BCE» + 7 points, in accordance with article L. 441-6 of the French Commercial Code. Our publications (report, database, tool...) are delivered only after reception of the payment. 3.5 In the event of termination of the contract, or of misconduct, during the contract, the Seller will have the right to invoice at the stage in progress, and to take legal action for damages. 4. Liabilities 4.1 The Buyer or any other individual or legal person acting on its behalf, being a business user buying the Products for its business activities, shall be solely responsible for choosing the Products and for the use and interpretations he makes of the documents it purchases, of the results he obtains, and of the advice and acts it deduces thereof. 4.2 The Seller shall only be liable for (i) direct and (ii) foreseeable pecuniary loss, caused by the Products or arising from a material breach of this agreement 4.3 In no event shall the Seller be liable for: a) damages of any kind, including without limitation, incidental or consequential damages (including, but not limited to, damages for loss of profits, business interruption and loss of programs or information) arising out of the use of or inability to use the Seller’s website or the Products, or any information provided on the website, or in the Products; b) any claim attributable to errors, omissions or other inaccuracies in the Product or interpretations thereof. 4.4All the information contained in the Products has been obtained from sources believed to be reliable. The Seller does not warrant the accuracy, completeness adequacy or reliability of such information, which cannot be guaranteed to be free from errors. 4.5 All the Products that the Seller sells may, upon prior notice to the Buyer from time to time be modified by or substituted with similar Products meeting the needs of the Buyer. This modification shall not lead to the liability of the Seller, provided that the Seller ensures the substituted Product is similar to the Product initially ordered. 4.6 In the case where, after inspection, it is acknowledged that the Products contain defects, the Seller undertakes to replace the defective products as far as the supplies allow and without indemnities or compensation of any kind for labor costs, delays, loss caused or any other reason. The replacement is guaranteed for a maximum of two months starting from the delivery date. Any replacement is excluded for any event as set out in article 5 below. 4.7 The deadlines that the Seller is asked to state for the mailing of the Products are given for information only and are not guaranteed. If such deadlines are not met, it shall not lead to any damages or cancellation of the orders, except for non acceptable delays exceeding [4] months from the stated deadline, without information from the Seller. In such case only, the Buyer shall be entitled to ask for a reimbursement of its first down payment to the exclusion of any further damages. 4.8 The Seller does not make any warranties, express or implied, including, without limitation, those of sale ability and fitness for a particular purpose, with respect to the Products. Although the Seller shall take reasonable steps to screen Products for infection of viruses, worms, Trojan horses or other codes containing contaminating or destructive properties before making the Products available, the Seller cannot guarantee that any Product will be free from infection. 5. Force majeure The Seller shall not be liable for any delay in performance directly or indirectly caused by or resulting from acts of nature, fire, flood, accident, riot, war, government intervention, embargoes, strikes, labor difficulties, equipment failure, late deliveries by suppliers or other difficulties which are beyond the control, and not the fault of the Seller. 6. Protection of the Seller’s IPR 6.1 All the IPR attached to the Products are and remain the property of the Seller and are protected under French and international copyright law and conventions. 6.2 The Buyer agreed not to disclose, copy, reproduce, redistribute, resell or publish the Product, or any part of it to any other party other than employees of its company. The Buyer shall have the right to use the Products solely for its own internal information purposes. In particular, the Buyer shall therefore not use the Product for purposes such as: - Information storage and retrieval systems; - Recordings and re-transmittals over any network (including any local area network); - Use in any timesharing, service bureau, bulletin board or similar arrangement or public display; - Posting any Product to any other online service (including bulletin boards or the Internet); - Licensing, leasing, selling, offering for sale or assigning the Product. 6.3 The Buyer shall be solely responsible towards the Seller of all infringements of this obligation, whether this infringement comes from its employees or any person to whom the Buyer has sent the Products and shall personally take care of any related proceedings, and the Buyer shall bear related financial consequences in their entirety. 6.4 The Buyer shall define within its company point of contact for the needs of the contract. This person will be the recipient of each new report in PDF format. This person shall also be responsible for respect of the copyrights and will guaranty that the Products are not disseminated out of the company. 6.5 In the context of annual subscriptions, the person of contact shall decide who within the Buyer, shall be entitled to access on line the reports on I-micronews.com. In this respect, the Seller will give the Buyer a maximum of 10 password, unless the multiple sites organization of the Buyer requires more passwords. The Seller reserves the right to check from time to time the correct use of this password. 6.6 In the case of a multisite, multi license, only the employee of the buyer can access the report or the employee of the companies in which the buyer have 100% shares. As a matter of fact the investor of a company, the joint venture done with a third party etc..cannot access the report and should pay a full license price. 7. Termination 7.1 If the Buyer cancels the order in whole or in part or postpones the date of mailing, the Buyer shall indemnify the Seller for the entire costs that have been incurred as at the date of notification by the Buyer of such delay or cancellation. This may also apply for any other direct or indirect consequential loss that may be borne by the Seller, following this decision. 7.2 In the event of breach by one Party under these conditions or the order, the non-breaching Party may send a notification to the other by recorded delivery letter upon which, after a period of thirty (30) days without solving the problem, the non-breaching Party shall be entitled to terminate all the pending orders, without being liable for any compensation. 8. Miscellaneous All the provisions of these Terms and Conditions are for the benefit of the Seller itself, but also for its licensors, employees and agents. Each of them is entitled to assert and enforce those provisions against the Buyer. Any notices under these Terms and Conditions shall be given in writing. They shall be effective upon receipt by the other Party. The Seller may, from time to time, update these Terms and Conditions and the Buyer, is deemed to have accepted the latest version of these terms and conditions, provided they have been communicated to him in due time. 9. Governing law and jurisdiction 9.1 Any dispute arising out or linked to these Terms and Conditions or to any contract (orders) entered into in application of these Terms and Conditions shall be settled by the French Commercial Courts of Lyon, which shall have exclusive jurisdiction upon such issues. 9.2 French law shall govern the relation between the Buyer and the Seller, in accordance with these Terms and Conditions.
  19. 19. © 2018 | www.knowmade.com KnowMadePatent & Technology Intelligence KNOWMADE Company presentation
  20. 20. 15 © 2019 All rights reserved | www.knowmade.com Nanopore Sequencing – Patent Landscape Analysis | February 2019 | Ref. : KM19002 WHAT WE DO Patents Technologies Prior art Scientific findings Opportunities Partners Competitors Newcomers M&A targets Patent landscape analysis Scientific review IP portfolio assessment Patent valuation Freedom-to-operate analysis Litigation & licensing support Patents linked to products Technology scouting Technology trends Competitive IP landscape Market trends Reverse engineering Make strategic decisions Sustain competitive advantages Speed R&D and enhance innovation process Align R&D and IP with key business objectives Strengthen IP portfolio and acquire technologies Anticipate risks and defend core businesses Explore new opportunities and monetize IP Knowmade helps customers to understand the competitive landscape, follow technology trends, and find out opportunities and threats in terms of technology and patents.  Interpreting the competitive landscape and technology developments throughout patents and scientific information.  Turning patents and scientific information into business intelligence tools that give you the capability to • Understand your competitive environment • Be ahead of technology trends • Identify patent & technology opportunities • Assess patent & technology risks • Define your IP and R&D strategy • Monetize your technologies and know-how • Defend your business  Strong technology expertise with an in-depth knowledge of patents.  Highly specialized analysts in the following sectors: Electronics, Telecommunications and Photonics Compound semiconductors, Power electronics, Batteries, Memories, RF electronics, Wireless communications, Solid-state lighting & display, Photonics, MEMS Sensors & Actuators, Semiconductor manufacturing, Packaging & Assembly. Life Sciences, Healthcare and Agri-Food Medical devices, Medical imaging, Microfluidics, Biotechnology, Pharmaceutics, Food-processing
  21. 21. 16 © 2019 All rights reserved | www.knowmade.com Nanopore Sequencing – Patent Landscape Analysis | February 2019 | Ref. : KM19002 WHAT WE PROPOSE Tailor-made analyses to meet your business needs and budgetary constraints Patent Landscape Analysis Patent-to-Product Mapping Patent Portfolio Analysis Patent Watch Taylor made to respond your requests Direct interaction between your team and our experts at your site Off the shelf reports and analyses Dedicated analyses Workshops and trainings
  22. 22. 17 © 2019 All rights reserved | www.knowmade.com Nanopore Sequencing – Patent Landscape Analysis | February 2019 | Ref. : KM19002 WHAT IS OUR ADDED VALUE Patent Search  Strong technical expertise of our analysts with PhD degree • Comprehensive search queries and keywords • Manual selection of relevant and related patents • Manual segmentation by technology & application Analytics  State of the art statistical tools  Innovative methodologies to deliver relevant IP analysis  Business oriented data representation and graphics Results Analysis  Technical expertise • Highly specialized analysts in your field • Benefit from knowledge capitalization  In-depth IP analysis combined with market data and reverse engineering *  Customer support * Our partners
  23. 23. 18 © 2019 All rights reserved | www.knowmade.com Nanopore Sequencing – Patent Landscape Analysis | February 2019 | Ref. : KM19002 CUSTOM STUDY & CONSULTING Tailor-made analysis to meet your needs and budgetary constraints Prior art search Patent landscape analysis Scientific literature analysis IP/Tech watch service Patent assessment Freedom- to-operate analysis Litigation & licensing support Technology scouting IP due diligence Prior art search Evaluate the patentability of your invention in the course of a patent filing. Invalidate competitor’s patents in the course of patent litigation or in anticipation of one. Make third-party observations concerning the patentability of competitor’s inventions. Patent landscape analysis Understand the competitive environment and the technology trends from a patent perspective. Identify key players, their IP strategy and their key patents. Know IP collaborations, licensing agreements and litigation history. Freedom-to-operate analysis Assess the risks to infringe third-party patents. Ensure that your products/processes can be safely manufactured, sold and used in specific countries without infringing patents held by others. IP due diligence Assess the patent portfolio of a company and reveal the SWOT matrix prior to patent acquisition/sale, licensing agreement or M&A. Scientific literature analysis Pinpoint key research findings and new emerging research fields, key laboratories and scientific experts, industrial/academic research collaborations, and identify prospective R&D partners. Patent assessment Identify most valuable patents prior to patent acquisition/sales, licensing agreement, capital fundraising process, M&A or IP due diligence. Estimate the financial value of your patent portfolio. Litigation and licensing support Evidence of infringement/non-infringement for offensive/defensive support. Defend your position in licensing negotiation or patent litigation. IP & Technology watch service Follow IP/technology trends, keep a watch on your competitors and identify new entrants, anticipate the changes, early detect business opportunities and mitigate the risks. Technology scouting Identify, qualify and get access to external innovation.
  24. 24. 19 © 2019 All rights reserved | www.knowmade.com Nanopore Sequencing – Patent Landscape Analysis | February 2019 | Ref. : KM19002 OFF THE SHELF REPORTS « Pre-packaged » analysis Knowmade team of experts work all year long to collect patent and scientific information, identify and analyze the trends, the challenges, the emerging technologies, the competitive environments, and turn it into results to give you a complete picture of your industry landscape. Every year, Knowmade publishes a comprehensive collection of reports in various technology fields. These fact-based analyses can provide you with the reliable information you need to advance your business and your competitive position.
  25. 25. 20 © 2019 All rights reserved | www.knowmade.com Nanopore Sequencing – Patent Landscape Analysis | February 2019 | Ref. : KM19002 OFF THE SHELF REPORTS 2019 reports collection COMPOUND SEMICONDUCTORS • GaN-on-Silicon Substrate: Materials, Devices and Applications – Patent Landscape 2019* • RF GaN: Materials, Devices and Applications – Patent Landscape 2019* • Power SiC: MOSFETs, SBDs and Modules – Patent Landscape 2019* • Power GaN: Materials, Devices and Applications – Patent Landscape 2019* • Patent Trolls in the Semiconductor Market – Litigation Risk and Potential Targets 2017 POWER ELECTRONICS • Power SiC: MOSFETs, SBDs and Modules – Patent Landscape 2019* • Power GaN: Materials, Devices and Applications – Patent Landscape 2019* • Fast Charging Technologies – Patent Landscape 2019* • Wireless Power Charging – Patent Landscape 2017 BATTERY AND ENERGY MANAGEMENT • Solid-State Batteries – Patent Landscape 2019* • Battery Energy Density Increase – Patent Landscape 2019* • Status of the Battery Patents – Patent Landscape 2018 • NMC Li-ion Batteries – Patent Landscape 2017 RF DEVICES & TECHNOLOGIES • Antenna for 5G Wireless Communications – Patent Landscape 2019* • RF Filter for 5G Wireless Communications – Patent Landscape 2019* • RF GaN: Materials, Devices and Applications – Patent Landscape 2019* • RF Front End Module for Cellphones – Patent Landscape 2018 • RF Acoustic Wave Filters: SAW, FBAR, SMR-BAW – Patent Landscape 2017 PHOTONICS & OPTOELECTRONICS • Silicon Photonics for Data Centers: Optical Transceiver – Patent Landscape 2019* • VCSEL – Patent Landscape 2018 • LiDAR for Automotive – Patent Landscape 2018 DISPLAY • MicroLED Displays – Patent Landscape 2018 IMAGING • Facial & Gesture Recognition Technlogies in Mobile Devices – Patent Landscape 2019* • VCSEL – Patent Landscape 2018 • LiDAR for Automotive – Patent Landscape 2018 • iPhone X Proximity Sensor and Flood Illuminator – Patent-to-Product Mapping 2018 MEDICAL IMAGING & BIOPHOTONICS • Optical Coherence Tomography Medical Imaging – Patent Landscape 2018 • Biomedical Photoacoustic Imaging – Patent Landscape 2015 SEMICONDUCTOR MANUFACTURING & PACKAGING • Hybrid Bonding for 3D Stack – Patent Landscape 2019* • Fan-Out Wafer/Panel Level Packaging – Patent Landscape 2019* • Fan-Out Wafer Level Packaging - Patent Landscape 2016 MEMORY • Magnetoresistive Random-Access Memory (MRAM) – Patent Landscape 2019* • 3D Non-Volatile Memories – Patent Landscape 2018 • Patent Trolls in the Semiconductor Market – Litigation Risk and Potential Targets 2017 • TSV Stacked Memories – Patent Landscape 2016 MEMS & SENSORS • MEMS Foundry Business IP Portfolio – Patent Portfolio Analysis 2019* • Miniaturized Gas Sensors – Patent Landscape 2019* • LiDAR for Automotive - Patent Landscape 2018 • iPhone X Proximity Sensor and Flood Illuminator - Patent-to-Product Mapping 2018 • RF Acoustic Wave Filters - Patent Landscape 2017 • Knowles MEMS Microphones in Apple iPhone 7 Plus - Patent-to-Product Mapping 2017 • Consumer Physics SCiO Molecular Sensor - Patent-to-Product Mapping 2017 BIOMEMS & MEDICAL MICROSYSTEMS • 3D Cell Printing – Patent Landscape 2019* • Circulating Tumor Cells Isolation – Patent Landscape 2019* • Nanopore Sequencing - Patent Landscape 2019* • Microfluidic Manufacturing Technologies – Patent Landscape 2019* • Pumps for Microfluidics - Patent Landscape 2017 • Microfluidic Technologies for Diagnostic Applications - Patent Landscape 2017 • Fluidigm - Patent Portfolio Analysis 2017 • Non-Invasive Glucose Monitoring - Patent Landscape 2015 BIOTECHNOLOGY & PHARMACEUTICS • Personalized Medicine – Patent Landscape 2019* • 3D Cell Culture Technologies – Patent Landscape 2016 * Coming soon Complete list of reports on www.knowmade.com
  26. 26. 21 © 2019 All rights reserved | www.knowmade.com Nanopore Sequencing – Patent Landscape Analysis | February 2019 | Ref. : KM19002 CONTACT o Consulting and Specific Analysis – North America: Steve LaFerriere, Director of Northern America Business Development, Yole Inc. Email: laferriere@yole.fr – Europe: Lizzie Levenez, Europe Middle East and Africa Business Development Manager, Yole Développement Email: levenez@yole.fr – Japan: Takashi Onozawa, General Manager, Yole Japan & President, Yole K.K. Email: onozawa@yole.fr – RoW: Jean-Christophe Eloy, President & CEO, Yole Développement, Email: eloy@yole.fr o Report business – North America: Steve LaFerriere, Director of Northern America Business Development, Yole Inc. Email: laferriere@yole.fr – Europe: Lizzie Levenez, Europe Middle East and Africa Business Development Manager, Yole Développement Email: levenez@yole.fr – Japan: Miho Ohtake, Japan Sales Manager, Yole K.K., Email: ohtake@yole.fr – Greater China: Mavis Wang, Business Development Manager, Yole China - Wang@yole.fr – Rest of Asia: Takashi Onozawa, President & General Manager, Yole K.K., Email: onozawa@yole.fr o Financial services – Jean-Christophe Eloy, CEO & President, Email: eloy@yole.fr o General: Email: info@yole.fr
  27. 27. 22 © 2019 All rights reserved | www.knowmade.com Nanopore Sequencing – Patent Landscape Analysis | February 2019 | Ref. : KM19002 KnowMade SARL 2405 route des Dolines 06902 Sophia Antipolis, France www.knowmade.com contact@knowmade.fr IP & Technology Intelligence

×