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Stem cell therapy for spinal 
cord injuries 
VISHNU AMBAREESH
japanese scientist Shinya Yamanaka
British scientist 
John B. Gurdon
Spinal cord injury became the first condition 
targeted in a human clinical trial using cells 
made from embryonic stem ce...
Doug Brutlag 2011 
Geron Stem Cell Therapy 
Tom Okarma - Geron
GRNOPC1 Improves Locomotor Behavior 
Doug Brutlag 2011 
after Spinal Cord Injury 
Tom Okarma - Geron
GRNOPC1 – contains oligodendrocyte progenitor cells. 
Which turn into oligodendrocytes, 
If GRNOPC1 works, the progenitor ...
Treatment of chronic spinal cord injured 
patients with autologous bone marrow-derived 
hematopoietic stem cell 
transplan...
Human Embryonic Stem Cell (hESC) 
Doug Brutlag 2011 
Based Therapy 
Tom Okarma - Geron
Doug Brutlag 2011 
GRNOP1 Phase 1 Multi-Center 
Spinal Cord Injury Trial 
Tom Okarma - Geron
• injected into the patients' spines 1-2weeks 
after injury between their third and 10th 
thoracic vertebrae, or roughly t...
Science is discovering the 
unknown 
• Stem cell field is still in its infancy 
• Human embryonic stem cell research is a ...
SHOULD WE DO IT???
Traditional Chinese herbal medicines 
an ancient medicinal practice, called Ji-Sui-Kang 
(JSK), can improve locomotor func...
“Stay clear of stem cell treatment for Spinal Cord Injury (SCI),” Professor Alan Mackay-Sim
AJIT JOGI
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
Stem cell therapy for spinal cord injuries
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Stem cell therapy for spinal cord injuries

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my physical medicine and rehabilitation seminar 2013.... kindly leave feedback as comments...

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Stem cell therapy for spinal cord injuries

  1. 1. Stem cell therapy for spinal cord injuries VISHNU AMBAREESH
  2. 2. japanese scientist Shinya Yamanaka
  3. 3. British scientist John B. Gurdon
  4. 4. Spinal cord injury became the first condition targeted in a human clinical trial using cells made from embryonic stem cells begun by Geron in 2010 later cancelled for financial reasons.
  5. 5. Doug Brutlag 2011 Geron Stem Cell Therapy Tom Okarma - Geron
  6. 6. GRNOPC1 Improves Locomotor Behavior Doug Brutlag 2011 after Spinal Cord Injury Tom Okarma - Geron
  7. 7. GRNOPC1 – contains oligodendrocyte progenitor cells. Which turn into oligodendrocytes, If GRNOPC1 works, the progenitor cells will produce new oligodendrocytes in the injured area of the patient's spine, potentially allowing for new movement.
  8. 8. Treatment of chronic spinal cord injured patients with autologous bone marrow-derived hematopoietic stem cell transplantation • Cairo University conducted human trial of hematopoietic progenitor stem cells in SCI Patients • Results: Improved functions • Not FDA approved • MRI showed no tumors • Awaiting 1 year follow up
  9. 9. Human Embryonic Stem Cell (hESC) Doug Brutlag 2011 Based Therapy Tom Okarma - Geron
  10. 10. Doug Brutlag 2011 GRNOP1 Phase 1 Multi-Center Spinal Cord Injury Trial Tom Okarma - Geron
  11. 11. • injected into the patients' spines 1-2weeks after injury between their third and 10th thoracic vertebrae, or roughly the middle to upper back. Later trials would include patients with less severe spinal injuries and damage to other parts of the spine. In lab animals, the results were dramatic - paralyzed rodents moved again.
  12. 12. Science is discovering the unknown • Stem cell field is still in its infancy • Human embryonic stem cell research is a decade old, adult stem cell research has 30-year head start • Holds hope for curing or improving treatments for 70+ diseases
  13. 13. SHOULD WE DO IT???
  14. 14. Traditional Chinese herbal medicines an ancient medicinal practice, called Ji-Sui-Kang (JSK), can improve locomotor function in rats withspinal cord injuries.
  15. 15. “Stay clear of stem cell treatment for Spinal Cord Injury (SCI),” Professor Alan Mackay-Sim
  16. 16. AJIT JOGI

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