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Molecular folding Veronica Sarassa González

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Molecular folding Veronica Sarassa González

  1. 1. Verónica Sarassa González School of Health Sciences Semester III February 12 / 2011
  2. 2. INTRODUCTIONElusive Z-DNA Found On Nucleosomes. (ScienceDaily Jan. 20, 2012).A team of researchers led by Dr Keji Zhao discovered that they could convertB-DNA to Z-DNA on nucleosomes.Human Immune Cells React Sensitively toStress‘. (ScienceDaily (Feb. 2, 2012).Scientists working with Professor BerndKaina of the Institute of Toxicology at theMedical Center of Johannes GutenbergUniversity Mainz demonstrated thatmonocytes are extremely sensitive toreactive oxygen species (ROS).
  3. 3. ELUSIVE Z-DNA FOUND ON NUCLEOSOMES. (Science Daily Jan. 20, 2012). • The DNA is the nucleic acid that carries the genetic information. • The B-DNA is the most known form of DNA.• The Z-DNA forms in a process of negative supercoiling, and it is a left-handed variety of the DNA . www.sciencedaily.com
  4. 4. ELUSIVE Z-DNA FOUND ON NUCLEOSOMES. (Science Daily Jan. 20, 2012). DNA ProteinNucleosome CromatinCromosome
  5. 5. ELUSIVE Z-DNA FOUND ON NUCLEOSOMES. (Science Daily Jan. 20, 2012). What did scientists thought? • Before: Z-DNA only forms in presence of RNA polymerase. • Now: The protein SWI/SNF can convert B in Z-DNA www.sciencedaily.com
  6. 6. ELUSIVE Z-DNA FOUND ON NUCLEOSOMES. (Science Daily Jan. 20, 2012). The Z-nucleosome is a new structure formed by the convertion of B-DNA to Z- DNA in nucleosomes, with the addition of SWI/SNF and ATP. www.sciencedaily.com
  7. 7. ELUSIVE Z-DNA FOUND ON NUCLEOSOMES. (Science Daily Jan. 20, 2012).Opinion: With the new forms of DNA, like Z-DNA in the near future scientists will be able to manipulate the genetic information.
  8. 8. ELUSIVE Z-DNA FOUND ON NUCLEOSOMES. (Science Daily Jan. 20, 2012). •Monocytes are white blood cells important in the inmune system. •These cells are made in the bone marrow, and they spread through the body in one to three days. They can develop into either dendritic cellsMonocyte or macrophages. •A type of white blood that ingests foreign material. Macrophages are key players in the immune response to foreign invaders such as infectiousMacrophage microorganisms. •Aggressive forms of oxygen that are generated during states of "oxidative stress" and play a significant role in various diseases. ROS
  9. 9. HUMAN IMMUNE CELLS REACT SENSITIVELY TO STRESS‘ (Sciencedaily (Feb. 2, 2012) Macrophages :Bloodstream Production Tissue Monocytes ROS www.sciencedaily.com
  10. 10. HUMAN IMMUNE CELLS REACT SENSITIVELY TO STRESS‘ (Sciencedaily (Feb. 2, 2012) Sensibility to ROSMONOCYTES MACROPHAGES www.sciencedaily.com
  11. 11. HUMAN IMMUNE CELLS REACT SENSITIVELY TO STRESS‘ (Sciencedaily (Feb. 2, 2012) ROS Are the reason for thisstudy, scientists wantedto show the relationshipbetween monocytes and them. They causedamages in the DNA and lead to cell death or malignant transformation. www.sciencedaily.com
  12. 12. HUMAN IMMUNE CELLS REACT SENSITIVELY TO STRESS‘ (Sciencedaily (Feb. 2, 2012)Opinion: Due to how dangerous ROS are, it is important to know the mechanisms that lead to the production of them, because in this way scientists can find a way to protect cells and the organism from them.
  13. 13. MEDICAL UTILITY: Elusive Z-DNA Found OnNucleosomes. (ScienceDaily Jan. 20, 2012) Regulation of the genetic expression. For example, in a family that the gen of albinism has been present throughout generations, the posssibility for it to stop expressing. www.sciencedaily.com
  14. 14. MEDICAL UTILITY: Elusive Z-DNA Found On Nucleosomes. (ScienceDaily Jan. 20, 2012) Block the genetic expression.For example, blocking the gene of cancer, that could appear in any time of a person’s life
  15. 15. MEDICAL UTILITY: Human Immune Cells React Sensitively to Stress‘. (ScienceDaily (Feb. 2, 2012) ROS will cellular oxidation, which willlead to the control of cell aging. With the pass of time, there will be more treatments that help people to avoid situations related with aging. www.sciencedaily.com
  16. 16. MEDICAL UTILITY: Human Immune Cells React Sensitively to Stress‘. (ScienceDaily (Feb. 2, 2012)Apoptosis will low it’s levels because of the reduction of the oxidant effect. MONOCYTE MONOCYTE
  17. 17. BIBLIOGRAPHY• ScienceDaily. Retrieved February 12, 2012, fromhttp://www.sciencedaily.com-/releases/2012/01/120120183042.htm • ScienceDaily. Retrieved February 12, 2012, from http://www.sciencedaily.com- /releases/2012/02/120202093834.htm • MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 2. ed. Medellín: UPB. Fac. de Medicina, 2006. 208
  18. 18. THANKS

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