Is there a problem withantimicrobial resistance in humans            & animals?
Problems with antimicrobial      resistance data                       1        3       2                Clinician/Vet   M...
% Antimicrobial resistance in Camp.jejuni in pigs & poultry in      %resistance in Campylobacter coli in pigs & poultry fr...
% resistance in E.coli from diseased pigs Dong Thap                    & Tien Giang 2005 (N = 50)100% 90% 80% 70% 60% 50% ...
% resistance in E.coli March – December 2012                                        Amoxicilin         AMC                ...
Comparison antimicrobial resistance non-typhoid Salmonella    spp. from humans and animals in southern March – December   ...
% antimicrobial resistance in E.coli & Salm spp from market                   rats in Dong Thap Province Jan 2013 (E.coli ...
Antimicrobial use in Viet NamUse at a farm levelUse in the communityDetails of use of antimicrobials in humans withinthe h...
Normal pig feed!Chlotetracyline50 mg/kg
Number (percentage) of chicken farms where     antimicrobials were present in the medicine cabinet                      No...
Number (percentage) of households where antimicrobials were                    present in the family medicine cabinet     ...
InterventionsRational use of antimicrobial in hospitalsControl of antimicrobials in communityDiagnostics in veterinary med...
AcknowledgementsThe Microbiology Dept.,                    • OUCRU:HTD: Bs.Lan                                • Prof. J. J...
Xin Cam On !
VIV Animal Health Summit Closing CEO-level Conference, Mr. James Campbell, VIV Asia 2013
VIV Animal Health Summit Closing CEO-level Conference, Mr. James Campbell, VIV Asia 2013
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VIV Animal Health Summit Closing CEO-level Conference, Mr. James Campbell, VIV Asia 2013

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Presentation given by Mr. James Campbell during the VIV Animal Health Summit Conference, March 14, at VIV Asia 2013

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VIV Animal Health Summit Closing CEO-level Conference, Mr. James Campbell, VIV Asia 2013

  1. 1. Is there a problem withantimicrobial resistance in humans & animals?
  2. 2. Problems with antimicrobial resistance data 1 3 2 Clinician/Vet Microbiologist Pharmacist
  3. 3. % Antimicrobial resistance in Camp.jejuni in pigs & poultry in %resistance in Campylobacter coli in pigs & poultry from Dong Thap Dong Thap Provence Feb 2012 (N =98) Province 2012 (N = 78) 100100 80 80 60 60 40 40 20 0 20 AMP AMC CRO CAZ Cl NA CIP OFX CN SXT DA ERY ESBL+ 0 antibiotic AMP CRO CL CIP CN DA ESBL+ % antimicrobial resistance in % antimicrobial resistance in Campylobacter jejuni children <5 years in HCMC Campylobacter coli children <5 years in HCM 2009- 2009-2010 (N=69) 100 2010 (N=91) 100 90 80 80 70 60 60 50 40 40 30 20 20 10 0 0 AMP AMC CRO CAZ Cl NA CIP OFX CN SXT DA E ESBL E NA Cl CN P DA T P C Z X O CI SX CA AM OF AM s CR po pos BL ES
  4. 4. % resistance in E.coli from diseased pigs Dong Thap & Tien Giang 2005 (N = 50)100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% OFX CIP CRO CAZ AMC C CN SXT AMP % resistance in E.coli from children with diarrheoa (N= 204) 2011-2012 HMC100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% OFX CIP CRO CAZ AMC C CN SXT AMP
  5. 5. % resistance in E.coli March – December 2012 Amoxicilin AMC Ceftazidine CAZ Ceftriaxone CRO Cloramphenicol C Meropenem MEM Tetracyclin TE Trimethoprim- sulfamethoxazole SXT Amikacin AK Gentamycine CN Ciprofloxacin 5 CIP5 Ampicillin AMP Chicken and Human data: from VIBRE study in Tien Giang 5 Colonies / individual sample
  6. 6. Comparison antimicrobial resistance non-typhoid Salmonella spp. from humans and animals in southern March – December 2012 human diarroheoa N = 79 70 human asymptomatic N = 92 60 animal N = 743 50 40% 30 20 10 0 AMP AUG CRO CAZ C CIP CN OFX SXT antibiotic
  7. 7. % antimicrobial resistance in E.coli & Salm spp from market rats in Dong Thap Province Jan 2013 (E.coli N=532: Salm.spp N=37) E.coli 26 Salm.spp 24 22 20 18 16 14% 12 10 8 6 4 2 0 AMC CAZ CRO C MEM TE SXT AK CN CIP5 AMP ESBL % Antimicrobial resistance in S.suis in rats (S.suis N=6)70605040302010 0 CM RD LE IMP OX ERY P TE FEP SXT VA CRO
  8. 8. Antimicrobial use in Viet NamUse at a farm levelUse in the communityDetails of use of antimicrobials in humans withinthe hospital settingUse in veterinary situations through The AnimalHealth Departments
  9. 9. Normal pig feed!Chlotetracyline50 mg/kg
  10. 10. Number (percentage) of chicken farms where antimicrobials were present in the medicine cabinet No. mediumAntimicrobial farms No. small farms Total No. of farmsgroups ( N=34 ) ( N=30 ) ( N=64 )Macrolides 13 ( 38% ) 4 (13% ) 17 ( 27% )Penicillins 10 (29% ) 8 (27% ) 18 (28% )Phenicols 6 ( 18% ) 1 ( 3% ) 7 ( 11% )Quinolones 12 ( 35% ) 9 (30% ) 21 ( 33% )Tetracyclines 13 ( 38% ) 13 (43% ) 13 (38% )Aminoglycosids 2 ( 6% ) 4 ( 13% ) 6 ( 9% )Sulfonamides 3 ( 9% ) none 3 ( 5% )Polypeptides 8 ( 24% ) 11 (37% ) 19 (30% )Lincosamides 2 ( 6% ) none 2 ( 3% )
  11. 11. Number (percentage) of households where antimicrobials were present in the family medicine cabinet No. of farm No. of rural No. of urban Total No. ofAntimicrobial households households households householdsgroups (N=24 ) (N=24 ) (N=15 ) ( N=63 )Aminopenicillis 7 ( 29% ) 5 (21% ) 3 ( 20% ) 15 ( 24% )Cephlasporins 10 (42% ) 20 (83% ) 6 (40% ) 36 (57% )Lincosamides 1 ( 4% ) none 1 ( 7% ) 2 (3% )Macrolides 5 ( 21% ) 6 ( 25% ) 4 (27% ) 15 ( 24% )Quinolones 1 ( 4% ) 2 ( 8% ) 1 ( 7% ) 4 ( 6% )Sulfonamides none none 1 ( 7% ) 1 ( 2% )Tetracyclines none 1 ( 4% ) 1 ( 7% ) 2 ( 3% )
  12. 12. InterventionsRational use of antimicrobial in hospitalsControl of antimicrobials in communityDiagnostics in veterinary medicine in Viet Nam asopposed to blanket antimicrobial useChanging farm practices with a view to reducingantimicrobial resistance
  13. 13. AcknowledgementsThe Microbiology Dept., • OUCRU:HTD: Bs.Lan • Prof. J. J. Farrar • N. V. M. Hoang • T. T. T. NgaAnimal Health Depts. • C. T. ThuyTien Giang Province • P. V. Minh • V. O. P. LinhL. M. Khanh • N. T. Son ChauDong Nai Province • OUCRU Zoonosis Group:T. V. Quang • N. T. HoaDong Thap Province • J. J. Carrique-Mas • VIBRE:N. B. Hien • N. V. Truong LL W E CO Wellcome Trust ME THE TR UST
  14. 14. Xin Cam On !

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