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CB3 Facilities and Agenda

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Presentation from Dennis Molfese at the Building Research Collaborations Workshop, Aug. 23, 2012

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CB3 Facilities and Agenda

  1. 1. Center for Brain, Biology, & Behavior Interdisciplinary Research Center Dennis L. Molfese, Ph.D. Mildred Francis Thompson Professor Director: Center for Brain, Biology & BehaviorDirector: Big Ten/CIC Traumatic Brain Injury Research Consortium Editor-In-Chief: Developmental Neuropsychology Director: Developmental Neuroscience Lab University of Nebraska -Lincoln
  2. 2. Acknowledgements –Cathryn Cortesa, BA –Nicole Earnest –Caitlin Hudac, MA –Kathleen Kelsey, MA –Srinivas Kota, Ph.D. –Christopher Rudasill, MFA –Nathan Petro, B.A. –Victoria Molfese, Ph.D.
  3. 3. Philosophy of The CenterFoster Interdisciplinary Collaborations.Provide Assess to BOTH Equipment & Training.Lead Paradigm Shift Within The Neurosciences: –- Move from “neural phrenology” to Understanding Brain’s Neural Spatial & Temporal Interconnectivty. –- Address Characteristics of Processing In and Between Brain Regions.
  4. 4. New Stadium AdditionsCenter for Brain, Biology,& Behavior Health & Performance Research Lab
  5. 5. Athletics/Academics Collaboration: An Unprecedented Initiative• Informs: –Medical & Behavioral Science –Athletic & Academic Training & Competition –Safety –Innovations
  6. 6. BIG 10 - Ivy League Concussion Research Collaboration• Consortium of 13 University Research & Sport Programs with BIG 10 CIC + 8 Ivy League Schools• Coaches• Trainers• Behavior & Brain Imaging Researchers• Shared data base for images, behavior data, test procedures & programs• Increasing external grant funding.
  7. 7. Unprecedented New Information • Screen Athletes Before Season (baseline) • Track Performance, Neurocognition & Brain Measures•Head Injured & Matched Controls•Assess Impact of Multiple Concussion•Shared Database Across Conferences • Design Interventions • Improve Equipment Design • Develop Concussion Awareness Programs
  8. 8. Facilities
  9. 9. 1st Floor
  10. 10. 2nd FloorReception
  11. 11. 2nd Floor
  12. 12. Internal Stairway Connecting 2nd and 3rd Floors
  13. 13. 3rd Floor
  14. 14. Science Work Group Areas for 2nd and 3rd Floors
  15. 15. Training Plan
  16. 16. Model for Training in Brain Imaging Techniques1. Workshop Introduction to Theory, Methods, Literature, Analyses (2-days)2. Consult on research design3. Hands-on training with equipment for setup, data collection, data processing & analysis.4. Assistance with: a. Data analyses b. Conference presentations c. Journal article drafts4. Grant submissions GOAL: Establish Dominance in Mainstream Research Areas Through Research & Grant Activities.
  17. 17. CB3 Training To Date October 1, 2010 - August, 2012• 8 Two-Day Workshop: 227 Faculty & Students• Advanced Imaging Training: 69 Faculty & Students• Current Research Studies: 12 Projects• Department Presentations: 38
  18. 18. Current Trainees = 26 08-22-2012
  19. 19. Available Technologies fMRI High Density Infant & Adult NIRS High-Density EEG/ERP Transcranial Magnetic Stimulation -TMS Behavior Science Labs Balance Labs Computer Labs Developmental Labs Endocrine Lab Eye Tracking Labs Genetics Lab
  20. 20. fMRI - functional Magnetic Resonance Imaging Siemens 3 Tesla Structure 70 cm bore DTI Function
  21. 21. fMRI - functional Magnetic Resonance Imaging QuickTime™ and a decompressor are needed to see this picture.
  22. 22. Diffusion Tensor Imaging
  23. 23. Magnetic Resonance Spectroscopy
  24. 24. fMRI Imaging Attachment Dyslexia
  25. 25. Balance Lab
  26. 26. Videonystagmography (VNG)Gait Testing Rotational Chair
  27. 27. Balance FunctionTesting Subjective Visual Vertical Functional Evaluation of Vestibulo-Ocu Reflex (VOR)
  28. 28. NIRS - Near-Infrared Spectroscopy
  29. 29. TMS - Transcranial Magnetic Stimulation Machine
  30. 30. High-Density ERP/EEG Event-Related Potentials (ERP) QuickTime™ and a QuickTime™ and a Cinepak decompressor are needed to see this picture. H.263 decompressor are needed to see this picture.Newborn Infant Adult
  31. 31. Front of Head NEWBORNLeft Side QuickTime™ and a Right Side Video decompressor are needed to see this picture. + - Back of Head
  32. 32. Front of Head AdultLeft Side Right Side + - Back of Head
  33. 33. Learning alters brain organization for acquisition of new information Same Shape Matching Task Different Low GRTR High GRTR [GRTR less than 11] [GRTR more than 11] QuickTime™ and a QuickTime™ and a Video decompressor Video decompressor are needed to see this picture. are needed to see this picture. Molfese et al, 2008
  34. 34. Eye TrackerEye Tracker + ERP net Eye Tracking Information
  35. 35. Intervention
  36. 36. ERPs in 2 to 4-Year-Old Preschool SLI Children Predict Subsequent Language Gains Following 4 Month Intervention Ability to discriminate /da/ from /ga/ Yoder, Molfese & Camarata, In Press
  37. 37. Concussion Intervention T Training Task ResultsAdditional Benefits
  38. 38. Concussion
  39. 39. Issues in Assessing Sports Concussion• 1. Little information on brain & behavior prior to concussion.• 2. Little long-term follow-up following concussion using standardized testing.• 3. Tests not comprehensive (e.g., ImPACT not effective in measuring attention, working memory).• 4. Little information available regarding prior head injuries.• 5. Falsification of pre-season tests by athletes.• 6. Pressure to resume play following possible head injury.• 7. No research-based information regarding when players can be safely returned to play.
  40. 40. Brain Deformation Following Side “Hit” Direction __Top View < of Force Direction __Side View < of ForcePellman et al., 2006
  41. 41. Brain Deformation Following Side “Hit” Direction __Top View < of Force Direction __Side View < of Force Force can producePellman et al., 2006 shearing
  42. 42. Vestibular Tests May Help to Identify and Manage ConcussionJulie Honaker, Ph.D.
  43. 43. Sports ConcussionWorking Memory: 2-back Match Nonmatch Match Nonmatch N2 N400
  44. 44. Self-reported symptoms & N2 No history of persistent History of persistent 2.5 nA headache (n=16) headache (n=19) .01 nA Match N2 Nonmatch
  45. 45. 20-40% with TBI experience vision-disorders Normal Visual World World at an Angle QuickTime™ and a GIF decompressor are needed to see this picture. Post-Trauma Vision Syndrome Visual Midline Shift Syndrome Hudac et al, 2011
  46. 46. QuickTime™ and a MPEG-4 Video decompressorare needed to see this picture.
  47. 47. Future Possibilities• Use brain imaging procedures to identify distortions produced by brain injury.• Identify intervention that can produce more normal neural processing.• Use the successful intervention to enable individual to perceive and interact with the world in more normal fashion.
  48. 48. Questions ???©2012 The Board of Regents of the University of Nebraska. All rights reserved.
  49. 49. fMRI - functional Magnetic Resonance Imaging
  50. 50. High-Density ERP/EEG: Newborn Infant QuickTime™ and a Cinepak decompressor are needed to see this picture. Event-Related Potentials (ERP)
  51. 51. High-Density ERP/EEG: Adult QuickTime™ and a H.263 decompressor are needed to see this picture.
  52. 52. Function fMRI Tracks Blood Flow in Brain DTI QuickTime™ and a Photo - JPEG decompres s or are needed to see this pic ture.ERP Structure 54
  53. 53. Key et al., In press 55

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