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The University of Southern Indiana (USI) is the lead convener in a regional initiative to drive transformational change in Southwest Indiana. This initiative is centered on the recent construction of a segment of Interstate 69 and aims to foster the establishment of an Innovation Corridor from Evansville to Crane in Southwest Indiana. The vision is to develop a culture and environment that uses innovation to transform and sustain the dynamism of the regional economy. A consortium of over 200 stakeholders has been engaged in developing strategies to increase the region’s innovation index by 20% by 2025.