Patrick Balthrop of Luminex on the Convergence of Health Care Technology and Public Policy

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Patrick Balthrop, President and CEO of Luminex, an R&D life sciences company, presents an optimistic future for health care delivery if technology and public policy decisions are made correctly. With DNA mapping, certain medicines can be targeted to patients with DNA profiles that respond. the future is personalized medicine. There won't be one prescription for one diagnosis, or blockbuster medicines.

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Patrick Balthrop of Luminex on the Convergence of Health Care Technology and Public Policy

  1. 1. Innovation and the Convergence of Technologies in the 21 st Century: The Century of Life Science
  2. 4. November 24, 1859
  3. 5. Charles Darwin <ul><li>HMS Beagle and Captain Fitzroy </li></ul><ul><li>Natural selection </li></ul><ul><li>Immutability of species </li></ul><ul><li>Church of England and Darwin’s mentors </li></ul><ul><li>“ Tree of Life” </li></ul><ul><li>Adaptation: “Species theory” </li></ul>
  4. 6. <ul><li>1700’s: Biology </li></ul>Science through the Centuries
  5. 7. <ul><li>1700’s: Biology </li></ul><ul><li>1800’s: Chemistry </li></ul>Science through the Centuries
  6. 8. <ul><li>1700’s: Biology </li></ul><ul><li>1800’s: Chemistry </li></ul><ul><li>1900’s: Physics </li></ul>Science through the Centuries
  7. 9. <ul><li>1700’s: Biology </li></ul><ul><li>1800’s: Chemistry </li></ul><ul><li>1900’s: Physics </li></ul><ul><li>2000’s: Life Science </li></ul>Science through the Centuries
  8. 10. 1700 Science through the Centuries 2009 1700 - Van Leeuwenhoek Microscope Biology 1859 – Darwin Natural Selection Biology 1866 – Mendel Genetics Biology 1880 - Pasteur Bacteriology Biology 1802 - Dalton Atomic Theory Chemistry 1869 – Mendeleev Periodic Table Chemistry 1950 - Pauling Chemical Bonds Chemistry 1983 - Mullis PCR Chemistry 2003 - Collins Human Genome Life Science 1937 - Turing Artificial Intelligence Physics 1900 - Curie Radioactivity Physics 1850 – Kelvin Thermodynamics Physics 1700 - Newton Gravity Physics 1953 – Watson & Crick DNA Biology
  9. 11. Human Genome and Human Proteome
  10. 12. Human Genome Project
  11. 13. Human Genome Project
  12. 14. Forbes’ 2009 Fastest Growing Technology Companies in America
  13. 15. Healthcare Reform BILL SIMILAR TO SENATE'S Months of talks yield $894 billion package HOW AN INSURANCE MANDATE COULD LEAVE MANY WORSE OFF Costs Keep Rising BUOYANT DEMOCRATS UNVEIL HEALTHCARE LEGISLATION
  14. 16. Personalized Medicine
  15. 17. Personalized Medicine - Tamoxifen
  16. 18. Personalized Medicine
  17. 19. Tamoxifen Efficacy by Genetic Profile Personalized Medicine Percentage of Patients Relapse-free survival Overall survival
  18. 20. The US Healthcare System is Procedure-Based
  19. 21. The US Healthcare System is Procedure-Based
  20. 22. Help is on the Way <ul><li>Medco's New Idea: PGx Program for Generics to Dispense 'Smarter' Treatments and Increase Savings </li></ul><ul><li>Breast Cancer: Genetics may hold key to prevention, treatment </li></ul><ul><li>SAEC Conducting Feasibility Gene-Association Study with HMO Network's E-Records </li></ul><ul><li>Medco Study to Gauge Whether PGx-Based Plavix Dosing is as Effective as Higher-Priced Effient </li></ul><ul><li>Generation Health Emulates the PBM Model to Optimize Genetic Testing for Payors </li></ul><ul><li>National Survey Shows Physicians See Value in Genetic Testing </li></ul>
  21. 23. <ul><li>Predicate device model </li></ul><ul><li>Not innovation-friendly </li></ul><ul><li>Critical Path Initiative </li></ul><ul><li>User fees </li></ul><ul><li>“ Rearview Mirror Navigation” </li></ul><ul><li>Review and reform underway </li></ul>Regulation: Strategic Considerations
  22. 24. 1700 Science through the Centuries 2000 1700 - Van Leeuwenhoek Microscope Biology 1859 – Darwin Natural Selection Biology 1866 – Mendel Genetics Biology 1880 - Pasteur Bacteriology Biology 1802 - Dalton Atomic Theory Chemistry 1869 – Mendeleev Periodic Table Chemistry 1950 - Pauling Chemical Bonds Chemistry 1983 - Mullis PCR Chemistry 2003 - Collins Human Genome Life Science 1937 - Turing Artificial Intelligence Physics 1900 - Curie Radioactivity Physics 1850 – Kelvin Thermodynamics Physics 1700 - Newton Gravity Physics 1953 – Watson & Crick DNA Biology 2009
  23. 25. Science through the Centuries 1700 - Van Leeuwenhoek Microscope 1859 – Darwin Natural Selection 1866 – Mendel Genetics 1880 - Pasteur Bacteriology 1953 – Watson & Crick DNA Physics 1802 - Dalton Atomic Theory 1869 – Mendeleev Periodic Table 1950 - Pauling Chemical Bonds 1983 - Mullis PCR Chemistry Century of Life Science Biology 1937 - Turing Artificial Intelligence 1900 - Curie Radioactivity 1850 – Kelvin Thermodynamics 1700 - Newton Gravity
  24. 26. R&D is Our Future NIH Budget 1990-2008 0 10 15 20 30 5 25 $ Billion
  25. 27. Progress Over the Last 100 Years *per Merck Manual 1899 1900 Present Death Rate per 100K Population, US 1,500 <800 Leading Causes of Death Heart disease, infectious disease Heart disease, cancer Treatment, Diabetes* Arsenic Insulin, BGM Treatment, Asthma* Tobacco Corticosteriods Treatment, Cardiac Disease* Cocaine Statins, stents, CABG Treatment, Insomnia* Cannabis Zolpidem, eszopiclone
  26. 28. Innovation and the Convergence of Technologies in the 21 st Century: The Century of Life Science

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