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Ulcer associated with Lichen Planus
•

The erosive form of lichen planus is ulcerated in the central area of the lesion

•

The ulcer is covered by fibrinous plaque or pseudomembrane.

•

Keratotic striae present peripheral to the erosion

•

painful

Histopathology
•

hyperkeratosis

•

interface lymphocytic infiltration

•

basilar vacuolization with apoptosis

Ulcer associated with Pemphigus Vulgaris
• lesions of pemphigus presnt painful ulcer preceded bu bullae .
persistent and progressive
• the bullae rapidly rupture leaving red painful ulcerated base
• positive Niklosky’s sing

Histopathology
• loss of desmosomal attachment result in suprabasal bullae contain
free-floating cells called ( Tzanck cells )
Ulcer associated with Mucous

Membrane Pemphigoid

• multiple painful ulcers preceded by vesicles and bullae
• lesions may heal with scar
• positive Niklosky’s sing
• may affect mucous membrane of oral cavity, eyes and genitals
Histopathology
• subepithelial bullae
• no acantholysis
• lymphocytes present and increase with time

Ulcer associated with Bullous

Pemphigoid

• skin disease appear in trunk and extremities with infrequent oral
lesions
• ulcers, preceded by bullae, are located on the attached gingiva most
common site
Histopathology
• subepithelial bullae which the basement membrane is cleaved at the
level of lamina lucida.

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Ulcers

  • 1. Ulcer associated with Lichen Planus • The erosive form of lichen planus is ulcerated in the central area of the lesion • The ulcer is covered by fibrinous plaque or pseudomembrane. • Keratotic striae present peripheral to the erosion • painful Histopathology • hyperkeratosis • interface lymphocytic infiltration • basilar vacuolization with apoptosis Ulcer associated with Pemphigus Vulgaris • lesions of pemphigus presnt painful ulcer preceded bu bullae . persistent and progressive • the bullae rapidly rupture leaving red painful ulcerated base • positive Niklosky’s sing Histopathology • loss of desmosomal attachment result in suprabasal bullae contain free-floating cells called ( Tzanck cells )
  • 2. Ulcer associated with Mucous Membrane Pemphigoid • multiple painful ulcers preceded by vesicles and bullae • lesions may heal with scar • positive Niklosky’s sing • may affect mucous membrane of oral cavity, eyes and genitals Histopathology • subepithelial bullae • no acantholysis • lymphocytes present and increase with time Ulcer associated with Bullous Pemphigoid • skin disease appear in trunk and extremities with infrequent oral lesions • ulcers, preceded by bullae, are located on the attached gingiva most common site Histopathology • subepithelial bullae which the basement membrane is cleaved at the level of lamina lucida.