Bleeding disorder1

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Oral Diagnosis I
Third Year

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Bleeding disorder1

  1. 1. Bleeding Disorders & Disorders of red and white blood cells. Aiman A. Ali DDS, PhD.
  2. 2. HAEMORRHAGE Aiman A. Ali DDS, PhD.
  3. 3. First Quiz Define the following: Bradycardia: Tachycardia: Atrial Flutter: Atrial Fibrillation: Agonal rhythm:
  4. 4. Extravasations of blood out of the vessels to the surrounding tissues either internally to the deep cavities and subcutaneously or externally. Aiman A. Ali DDS, PhD. Normal control of bleeding 1. Vascular phase 2. Platelet phase & coagulation 3. Metabolic “fibrinolytic” phase
  5. 5. 1- Vascular phase 2- Platelet phase 3- Coagulation phase 4- Metabolic “fibrinolytic” phase
  6. 6. Classification of bleeding disorders Non-thrombocytopenic purpuras  Vascular wall alterations  Disorder of platelet function Thrombocytopenic purpuras  Primary [idiopathic]  Secondary Disorder of coagulation  Inherited  Acquired
  7. 7. Thrombocytopenic Disorders  Primary: Idiopathic  Secondary:  Systemic diseases (leukemia)  Radiation  Bone Metastasis  Viral or bacterial infections  Drugs: Alcohol, Gold salts, Estrogens, Thiazide diuretics Aiman A. Ali DDS, PhD.
  8. 8. Non-Thrombocytopenic Disorders  Vascular wall alteration:  Scurvy  Infections  Allergy  Disorders of platelet function:  Genetics (Bernard-Soulier disease)  Allergy  Autoimmune disease  Von willebrand’s disease  Uremia  Drugs: Aspirin, NSAIDs, Alcohol, Beta-Lactam antibiotics Aiman A. Ali DDS, PhD.
  9. 9. Disorder of coagulation  Inherited:  Hemophilia A  Hemophilia B  Acquired:  Liver diseases  Vitamin deficiency  Anticoagulation drugs: Heparin, aspirin NSAIDs  Primary fibrinogenolysis Aiman A. Ali DDS, PhD.
  10. 10. Bernard Soulier Syndrome Aiman A. Ali, DDS, PhD. Hereditary. - Giant non-functional platelets. - Bleeding tendency.
  11. 11. 1- Disorders of platelets: 1.1.- Diseases. Aiman A. Ali DDS, PhD. 1.2.- Drugs:
  12. 12. Aiman A. Ali DDS, PhD. Immune Thrombocytopenia. Hypersplenism. 1-1 Diseases: Thrombocytopenia: - normal platelet count is about 150-350x103/mm3 - thrombocytopenia exists when the platelet count falls below 100X 103/mm3. Idiopathic thrombocytopenic purpura. AIDS associated purpura.
  13. 13. 1.2.- Drugs: 1- Aspirin and other NSAIDS such as: diclofenac, Ibuprofen mefenamic acid 2- Lactam antibiotics: penicillin, cephalosporins 3- General anesthetic agents: Halothane 4- Others: tetracycline, antidepressant, alcohol, heparin, thiazide & diuretics Aiman A. Ali DDS, PhD.
  14. 14. Signs and Symptoms: 1- Spontaneous gingival bleeding. 2- Purpura. 3- Petechiae. 4- Ecchymosis. 6- Post operative bleeding. 5- Prolonged : epistaxis, spontaneous bleeding into GIT and anemia Aiman A. Ali DDS, PhD.
  15. 15. Aiman A. Ali DDS, PhD.
  16. 16. 2. Coagulation Defects Aiman A. Ali DDS, PhD.

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