Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.

4.anti colinergic


Published on

Third Year

  • Nice one..
    Are you sure you want to  Yes  No
    Your message goes here

4.anti colinergic

  1. 1. AnticholinergicAnticholinergic drugsdrugs Dr Heba A. Mahmoud
  2. 2. Anti-muscarinic drugsAnti-muscarinic drugs Mode of action: Competitive antagonist compete with acetyl choline for muscarinic receptors
  3. 3. Actions ofActions of Anti-CholinergicsAnti-CholinergicsActions ofActions of Anti-CholinergicsAnti-Cholinergics Eye: blocks all cholinergic activity on the eye, resulting in  passive mydriasis  cycloplegia (inability to focus for near vision).  Increase intraocular pressure CVS: ↑HR (after initial HR)↓ ↑ AVN conduction Large dose atropine flush Respiratory system: bronchodilatation ↓ secretions
  4. 4. Actions of Anti-CholinergicsActions of Anti-Cholinergics GIT: antispasmodic reduce gastrointestinal tract motility ↓ gastric secretion dry mouth and constipation Urinary system: Relax bladder and retention of urine Secretions: decrease all secretions (except milk, bile) CNS: excitatory , inhibition of Vomiting centre , antiparkinsonian. Anti-motion sickness
  5. 5. Therapeutic uses of Anti-CholinergicsTherapeutic uses of Anti-Cholinergics Fundus examination and iridocyclitis (Mydriatic ) Atropine Tropicamide is used but short acting, 2 - 4 hrs Antidote for cholinergic agonists e.g. Organophosphorus poisoning (Atropine )  Heart block, vasovagal attack (Atropine ) Intestinal, biliary and renal Colic (hyoscine butyl bromide) Motion sickness (hyoscine) Peptic ulcer: pirenzepine
  6. 6. Therapeutic uses of Anti-CholinergicsTherapeutic uses of Anti-Cholinergics (cont.)(cont.) Nocturnal enuresis and urinary incontinence (emebronium is better) . Parkinsonism (benztropine) Bronchial asthma ipratropium is used by inhalation Preanesthetic medication to stimulate respiratory center , prevents vomiting, prevent excess bronchial and salivary secretions and protect heart from excess vagal tone (Hyoscine)
  7. 7. Anti-CholinergicsAnti-Cholinergics adverse effectsadverse effects  Dry mouth  Blurred vision, xero-ophthalmia (dry eye), glaucoma  Tachycardia  Constipation  Retention of urine  Hot and flushed skin Anti-CholinergicsAnti-Cholinergics contraindicationcontraindication  Glaucoma  Tachycardia  Paralytic ileus  Senile hypertrophy of prostate  Allergy to atropine