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GeneMind Introduction.pdf

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GeneMind Introduction.pdf

  1. 1. E x p l o r e L i f e ’ s M y s t e r i e s f o r B e t t e r H e a l t h c a r e
  2. 2. Company Introduction Specializing in the independent R&D and manufacturing of molecular diagnosis technology platform centred on DNA sequencing system, GeneMind Biosciences is devoted to constructing a precision medicine ecosystem to serve human life and health through collaboration with genetic testing service providers and medical institutions. GeneMind has launched the single-molecule sequencing platform GenoCare 1600 and the high-throughput sequencing platform GenoLab M through independent research and innovation, and offers the “equipment-reagent-flowcell- software” total platform solution. GeneMind is one of the few technology companies with core upstream technology and independent brand of gene sequencing in the world. GenoCare 1600 is the world’s first single-molecule sequencer that has passed medical device clinical trials. · A high-tech enterprise with core technologies of gene sequencing and independent intellectual property rights High-tech · One of the few independent brands of gene sequencers in the world Self-owned brand · Single-molecule sequencer+ High-throughput sequencing platform Volume Production
  3. 3. E s t a b l i s h e d i n Shenzhen, China. July 2012 S t a r t R & D o f single-molecule sequencer. S e p t e m b e r 2014 T h e f i r s t principle prototype of GenoCare single- molecule sequencing platform was born. O c t o b e r 2015 Official completed the GMP production line of sequencers and reagents. September 2018 G e n o C a r e 1 6 0 0 single-molecule s e q u e n c e r successfully passed the medical device r e g i s t r a t i o n inspection of NMPA. F e b r u a r y 2019 G e n o C a r e h a s completed medical d e v i c e c l i n i c a l t r i a l s , a n d t h e p o s i t i v e a n d negative coincidence rate has reached 100%. May 2020 The GenoLab high- t h r o u g h p u t s e q u e n c i n g p l a t f o r m w a s o f f i c i a l l y launched. O c t o b e r 2020 Approved to establish the first provincial a c a d e m i c i a n workstation dedicated to the development of sequencer platform in China——Guangdong A c a d e m i c i a n workstation. November 2021 Milestones
  4. 4. Core Technologies Optical System Hardware The high sensitivity and high resolution optical system can quickly complete the fluorescence signal acquisition Base calling algorithm Software Complete the output from the original image information acquisition to the sequencing accurately and quickly Different specifications are available Flowcell High sensitivity; High resolution Nucleotide analogues and polymerases Chemistry The unique termination base structure and high fidelity polymerase provide high precision detection
  5. 5. Products Able to run one flow cell alone or two flow cell simultaneously Dual flow cell mode Pre-configured reagent kit Easy-to-use Multiple throughput types available Flexible Open to mainstream NGS libraries Compatible Specifications Flowcell Two (Able to run one flow cell alone or two flow cell simultaneously) Reads/Run 250 M×2(FCM); 500 M×2(FCH) Read Length SE75、SE150、PE75、PE150 Output/Run 37~150 Gb(FCM);75~300 Gb(FCH) Turnaround time 13~43 h(FCM);16~53 h(FCH) Q30 Q30>85% GenoLab M High-throughput Sequencing Platform
  6. 6. Reproductive Health Genetic & Rare Diseases Infection prevention and control Oncology Animal Genomics Agrigenomics Applications
  7. 7. I n d e p e n d e n t R & D a n d M a n u f a c t u r i n g C a p a b i l i t y The total area of ​​R&D and production put into use by GeneMind is nearly 10,000 square meters. The company estalished sequencer production factory, flowcell laboratory,GMP production line for kits, organic synthesis laboratory, and enzyme engineering laboratory. The mass-produced products cover sequencing instruments, sequencing kits,and flowcell. · Flowcell Lab Can be produced by ourselves · Sequencer Production Line Annual capacity is 1000 units · Reagent Kits Production Line Designed as a GMP workshop to produce kits for 2.4 million tests annually ·Enzyme Engineering Lab Independent research and development of core enzyme · Organic Synthesis Lab Able to synthesize our own nucleic acid and fluorochrome
  8. 8. Partners Instrument Regeant Software Flowcell

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