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Histology of pancreas.pdf

This document discusses the histology and microscopic anatomy of the pancreas. It describes the exocrine and endocrine components. The exocrine pancreas is composed of acinar cells that secrete digestive enzymes into small ducts. The endocrine pancreas is made up of islets of Langerhans, which contain alpha, beta, delta, and F cells that secrete glucagon, insulin, somatostatin, and pancreatic polypeptide respectively. The document also discusses pancreatic stellate cells and their role in fibrosis and repair after pancreatic injury.

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Histology of
pancreas
Dr.Tim Mutafya
General Surgery resident-COSECSA
Kamuzu Central Hospital
Layout
1
Anatomical
relations
2
Macroscopic
pancreas
3
Microscopic
pancreas
Histology of pancreas.pdf
Histology of pancreas.pdf
Macroscopic
Gland volume
distribution
• 85% Exocrine pancreas
• 10% extracellular matrix
• 3% blood vessels and
ducts
• 2% endocrine pancreas
Microscopic
Acinar cells
• Digestion function
Islet of Langerhans
• Endocrine function
Pancreatic stellate cells
• Repair of injuries

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Histology of pancreas.pdf

  • 1. Histology of pancreas Dr.Tim Mutafya General Surgery resident-COSECSA Kamuzu Central Hospital
  • 5. Macroscopic Gland volume distribution • 85% Exocrine pancreas • 10% extracellular matrix • 3% blood vessels and ducts • 2% endocrine pancreas
  • 6. Microscopic Acinar cells • Digestion function Islet of Langerhans • Endocrine function Pancreatic stellate cells • Repair of injuries
  • 8. Exocrine pancreas • Has 3 functional units(lobule) • Acinar cells  synthesize and secrete the digestive enzymes • Centroacinar cells  Secrete bicarbonate and mucin  Represents beginning of ducts • Intercalated ducts  site of buffering secretions No myoepithelial cells around acini
  • 12. Endocrine pancreas The secretory unit of endocrine pancreas • The islet of Langerhans • 2% of all pancreatic cells( 1-2million) and Majority are located in the tail • Demarcated from rest of parenchyma by reticular fibers The hormones of the endocrine pancreas are the primary regulators of glucose, lipid and protein metabolism.
  • 13. • Islets are permeated by many fenestrated capillaries which allow quick entry of pancreatic hormones into the blood. • The cells are connected by desmosomes and gap junctions forming bands or cords of cells
  • 14. - cells- Insulin • 60- 70% of the islet cells. Contain many secretory granules which possess a dark center with crystallized insulin, surrounded by a wide pale halo. A (alpha) cells • 15-20% of the islet cells. Usually larger than B cells • Secrete glucagon • located peripherally in the islet. • Have uniform granules filled with glucagon(thin hallo) - cells- Somatostatin • 5-10% of the islet cells. • Diffusely distributed but most commonly in the periphery. • Contain larger secretory granules compared to  and  - cells - Pancreatic polypeptide • <5% of the islet cells. • They are mostly located within the head of the pancreas. - cells -Glucagon • 15-20% of the islet cells. Usually larger than B cells • located peripherally in the islet. • Have uniform granules filled with glucagon(thin hallo) Islotes pancreáticos
  • 16. Pancreatic stellate cells (PaSCs) • Myofibroblast-like cells that are located in exocrine regions of the pancreas • Naturally in quiescent state • Compose 4% of the total cell mass in the gland • Located in periductal and perivascular regions of the pancreas and contain vitamin A lipid droplets in their cytoplasm. PaSCs produce metalloproteinase and their inhibitors, which assist in the turnover and remodeling of the pancreatic extracellular matrix (ECM) after injury • MMP-2, MMP-9, and MMP-13
  • 17. Following activation, PaSCs migrate to areas of tissue damage and contract, phagocytose, and induce products that regulate the ECM through facilitating repair or by promoting fibrosis Ethanol
  • 18. inflammation or injury to the pancreas
  • 19. Clinical significance of PaSCs Chronic pancreatitis • Persistent injury to the pancreas leads to the sustained activation of the active PaSCs phenotype with diminished production of MMPs leading to fibrosis and pancreatic cell dysfunctions. - chronic alcohol use, - pancreatic duct obstruction or genetic. Pancreatic cancer Pancreatic tumor cells stimulate the proliferation of PaSCs through the secretion of PDGF, and induce PaSCs production of ECM proteins by secretingTGF-β1 and FGF-2 Cancer Res. 2008;68(19):7707-7710. doi:10.1158/0008-5472.CAN-08-1132
  • 21. References 1. https://www.kenhub.com/en/library/anatomy/pancreas-histology 2. https://doi.org/10.1016/S0039-6109(16)36593-8 3. https://www.bing.com/ck/a?!&&p=2da27acabe4d662bJmltdHM9MTcwMDAwNjQwMCZpZ3VpZD0xMWM yM2ZlOC04MmMwLTYwZjItM2FmZi0yY2MyODNjMDYxYzcmaW5zaWQ9NTIwMA&ptn=3&ver=2&hsh=3 &fclid=11c23fe8-82c0-60f2-3aff- 2cc283c061c7&psq=netter%27s+atlas&u=a1aHR0cHM6Ly9hcmNoaXZlLm9yZy9kZXRhaWxzL0F0bGFz T2ZIdW1hbkFuYXRvbXlTaXh0aEVkaXRpb25GcmFua0guTmV0dGVyTS5EXzIwMTgwMw&ntb=1 4. Slideshare 5. Bailey & Love’s Short Practice of Surgery 28th Edition PDF