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ppt• protein binding, drug distribution and clearance may be altered. • Because of the alteration in these variables, wide intraindividual variation of pharmacokinetic parameters occurs depending upon the time since thermal injury and fluid resuscitation. • Interindividual variations may be correlated with the percentage of the body surface area that is burnt,

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BURNS:
The pharmacokinetics and
pharmacodynamics of drugs are
significantly altered in the burn
patient, and the burn patient
population shows wide inter- and
intraindividual variation in drug
handling.
• Burn injury evolves in two phases.
• The first phase corresponds to the burn shock,
which occurs during the first 48 hours after
thermal injury.
In this phase, hypovolaemia, oedema,
hypoalbuminaemia and a low
glomerular filtration rate are observed,
which result in a slower rate of drug
distribution and lower renal clearance.
• The second phase (beyond 48 hours after
injury) is a hyperdynamic state with high
blood flow in the kidneys and liver, an
increased α1-acid-glycoprotein level and loss
of the drug with exudate leakage. As a result,
protein binding, drug distribution and
clearance may be altered.
• protein binding, drug distribution and clearance
may be altered.
• Because of the alteration in these variables, wide
intraindividual variation of pharmacokinetic
parameters occurs depending upon the time
since thermal injury and fluid resuscitation.
• Interindividual variations may be correlated with
the percentage of the body surface area that is
burnt,
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ppt.pptx

  • 1. BURNS: The pharmacokinetics and pharmacodynamics of drugs are significantly altered in the burn patient, and the burn patient population shows wide inter- and intraindividual variation in drug handling.
  • 2. • Burn injury evolves in two phases. • The first phase corresponds to the burn shock, which occurs during the first 48 hours after thermal injury.
  • 3. In this phase, hypovolaemia, oedema, hypoalbuminaemia and a low glomerular filtration rate are observed, which result in a slower rate of drug distribution and lower renal clearance.
  • 4. • The second phase (beyond 48 hours after injury) is a hyperdynamic state with high blood flow in the kidneys and liver, an increased α1-acid-glycoprotein level and loss of the drug with exudate leakage. As a result, protein binding, drug distribution and clearance may be altered.
  • 5. • protein binding, drug distribution and clearance may be altered. • Because of the alteration in these variables, wide intraindividual variation of pharmacokinetic parameters occurs depending upon the time since thermal injury and fluid resuscitation. • Interindividual variations may be correlated with the percentage of the body surface area that is burnt,