Surya

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Surya

  1. 1. Atherosclerosis By Suriya
  2. 2. INTRO ….. <ul><li>ARTERIOSCLEROSIS </li></ul><ul><li>hardening or thickening of blood vessel </li></ul><ul><li>loss of elasticity of vessel wall </li></ul>
  3. 3. Types of arteriosclerosis <ul><li>Arteriolosclerosis </li></ul><ul><li>hyaline </li></ul><ul><li>hyperplastic </li></ul><ul><li>monckeberg’s medial calcific sclerosis </li></ul><ul><li>atherosclerosis </li></ul>
  4. 4. Atherosclerosis <ul><li>Greek word </li></ul><ul><li>Athero-protruding, sclerosis-scarring </li></ul><ul><li>Atherosclerosis-gruel/hardening </li></ul><ul><li>Def: </li></ul><ul><li>Intimal lesions – atheromas </li></ul><ul><li>Protrude into and obstruct vascular lumens and weaken underlying media </li></ul>
  5. 6. <ul><li>Global in distribution </li></ul><ul><li>Mortality - half of all deaths…. </li></ul><ul><li>Morbidity - higher than other disease in western world </li></ul><ul><li>Increasing in developed and industrialized countries </li></ul>
  6. 9. Epidemiologic data……… <ul><li>25% of deaths in USA is of MI </li></ul><ul><li>Mortality rate for IHD in USA is high(5 times of Japan) </li></ul><ul><li>IHD-2 nd leading cause of death in Japan </li></ul><ul><li>1963-2000 </li></ul><ul><li>↓ in 50% death rate due to IHD </li></ul><ul><li>↓ in 70% death rate due to stroke </li></ul>
  7. 10. <ul><li>In New Orleans </li></ul><ul><li>Postmortem findings of coronary atherosclerosis in persons of age 25-44 yrs in 1968-72 is comparatively less as in 1960-64 </li></ul>
  8. 13. <ul><li>Constitutional </li></ul><ul><li>Age </li></ul><ul><li>Sex </li></ul><ul><li>Genetics </li></ul><ul><li>Family history </li></ul><ul><li>Acquired </li></ul><ul><li>Hyperlipidemia </li></ul><ul><li>Hypertension </li></ul><ul><li>DM </li></ul><ul><li>Cigarette smoking </li></ul><ul><li>CRP </li></ul>MAJOR
  9. 14. MINOR <ul><li>Obesity </li></ul><ul><li>Physical inactivity </li></ul><ul><li>Stress </li></ul><ul><li>Postmenopausal estrogen deficiency </li></ul><ul><li>Diet </li></ul><ul><li>Alcohol </li></ul><ul><li>Lipoprotein a </li></ul><ul><li>Coagulation factors </li></ul><ul><li>Infections </li></ul>
  10. 16. AGE <ul><li>Dominant influence </li></ul><ul><li>40-60 yrs of age-incidence of MI ↑ by 5 folds </li></ul>
  11. 18. SEX <ul><li>Male </li></ul><ul><li>Postmenopausal women </li></ul><ul><li>In elderly , both have equal risk </li></ul>
  12. 21. GENETICS <ul><li>Polygenic </li></ul><ul><li>Familial diseases-HYT,DM </li></ul><ul><li>Inborn metabolic errors-Familial </li></ul><ul><li>hyperlipidemia </li></ul>
  13. 24. HYPERLIPIDEMIA <ul><li>Hypercholesterolemia </li></ul>
  14. 27. <ul><li>High cholesterol diet & saturated fats - ↑ cholesterol level </li></ul><ul><li>Low cholesterol diet & polyunsaturated fats - ↓ cholesterol level </li></ul><ul><li>Exercise & moderate consumption of ethanol - ↑ HDL level </li></ul><ul><li>Obesity & smoking - ↓ HDL level </li></ul>
  15. 30. Hypertension <ul><li>↑ risk of IHD by 60% </li></ul><ul><li>HYT -> LVH -> IHD </li></ul>
  16. 45. THANK U! Success would be a failure without successors LIFE SAVER

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