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The Cambridge Phenomenon
50 Years of Innovation and Enterprise
The Cambridge Phenomenon
The evolution of an
Entrepreneurial Ecosystem
Story of a Progression towards Open Innovation
and a Culture embracing Connected Interests - a
story still unfolding - and a personal set of
thoughts - not an academic paper. Focus on
people.
Professor Alan Barrell
Relating to History and visionary romance - starting
with the concept of the Agora of Ancient Athens
about 600 BC
A special central place for all and everything - meeting, greeting, eating, exchanging,
learning - voting. Birthplace of the Athenian Democratic Process. Politicians,
philosophers, criminals, traders, aristocrats, scientists, officials and slaves - all passed
through and made contact there. A model of an epicentre of knowledge sharing. Does
Cambridge represent a Agora for today and tomorrow?
Great minds “brainstorming” in the Agora at Athens
Fresco by Raphael - now in The Vatican
Scientific Theory - not called by that name then- got started in the
Agora sessions. Socrates, Plato and Aristotle and others met,
socialised, philosophised and instructed students here. Perhaps we
see parallels in Cambridge today?
Living Longer – not always Healthier – big dilemma
World Population 1953 3.5 billions : 2014 7.5 billions : 2025 - ? 10 billions….
There is another Context to our Cambridge Story – Our World Today –
Reminders – Challenges
Climate Change and Energy Food and Water
Seismic Changes
in World
Economy
The Century of Science
and Technology
A “New Renaissance” – Age of
Education – Example - 8.3million new
graduates in China in 2018
BIG Opportunities for creative R&D, Businesses and
Entrepreneurs
Getting back to Cambridge - amidst these tranquil surroundings…..
great Centre of Learning ….and the story of an economic
transformation
800 years + of
academic excellence
The Cambridge Phenomenon
Attracting global interest and admiration - local pride and local
concerns. Innovation and change are mixed blessings
Population of Cambridge approx. 130,000
Of which, around 25,000 are students
Reminder - Cambridge is a very small city
“Greater Cambridge” sub region 650,000
East of England Region 6.5 million
52 107
More Nobel prize winners than most countries (and Oxford!)
Always a risk my numbers will be out of date!
Cambridge and the Eastern Region – a Transformation
Regional Example – the last 60 years
Traditional Industries
•Agriculture and Food
•Fishing
•Leather goods - Footwear
•Wool and Textiles
•6.5 million people now
•Now One of UKs fastest growing
regions in Europe
•Traditional Industries dead, dying or
gone away….
60 years ago – this was a deprived and declining region.
University has played a key role in recovery
Worstead and
Thetford in
Norfolk -
Centres of the
First Great
Wool Trade
Last reported
annual growth
9%!
Cambridge Ideas have changed the World….but regional
economic development did not follow….for centuries
Ideas that Changed the World –
not historically to the great
benefit of Cambridge, the
Region or the Nation….
R&D alone doesn’t create
wealth or social good. R&D
is NOT innovation
But Cambridge has had Innovators - some
examples of wonderful changemakers….
Mathematics and the
start of “computer
thinking”
Charles Babbage –
Cambridge man and
some say “father
and mother of
computing”
Babbage’s “Difference Machine” – 1880 – Cambridge
“Difference
Calculating Machine”
Ada Lovelace –
illegitimate daughter
of Lord Byron
World’s first
computer
programmer?
Ada’s Algorithms.
That is what we
would call them
today
Oh for a laptop! What would she have achieved?
Admired and feted by Prince Albert
And somewhat later - mainframe computing and the
EDSAC - world leadership in Cambridge
Sir Maurice Wilkes hero of computer science and design
Inventing the future in 1937
A history of true invention and creativity
EDSAC in the 1940s
The Maurice Wilkes Building at St John’s Innovation Centre
Not only in memory - but enabling future
inventions and technology development
From Babbage and his
“Difference
machine”through
Wilkes and others from
1880 - to Raspberry Pi
2012– a leap in time,
technology, size and
scale.
Jack Lang, first
Chairman Raspberry
Pi Foundation.
Computer
Programming for ALL
Raspberry Pi a revolution in scale , power
and cost
It is TINY……as
shown by co-
founder Dr
David Braben
here
But POWERFUL !
Big Data from Tiny Devices
25 million Raspberry Pi computers
sold ( ByFebruary 2019)
Changing the world and enabling thousands to benefit.
Myriads of applications.
Long before Raspberry Pi - Alan Turing - Code
breaker and computer science leader in WW 2
and father of Artificial Intelligence
A hero and visionary - unrecognised and very
badly treated in his own lifetime. Kings College
Cambridge. Today we have The Turing Institute
and his contribution acknowledged.
More world changing science – “Cambridge Ideas Change the
World”
1953 Crick and Watson – Double Helix – DNA 1953
Great Bioscience discoveries in a Physics Lab. - The
Cavendish - more great names to recall - Rutherford, JJ
Thomson, Bragg, Clerk-Maxwell, Mott, Max Perutz and more
DNA Crick and
Watson 1953 at Old
Cavendish Labs
And across the street….a
friendly pub - with the best
beer….
The Eagle Pub - where it is
reported Crick and Watson
first reported one of the
greatest discoveries in the
history of science - DNA -
The Double - “The Secret of
Life”
Enjoy a glass of “DNA ALE”
there anytime….
The house that
Crick lived in
20 Portugal Place
with Double Helix
The Francis Crick Institute – Leading Edge Medical Research
World class teams connected with other leaders in other
UK and International Centres – breaking new ground in
Cancer Research and other key areas
Lest we forget - The Double Helix discovery was possible through
the work of Rosalind Franklin
An untimely death, politics and other factors deprived her of the
recognition she deserved and deserves.
Shankar Balasubramanian and David Klenerman
DNA polymerase and laser spectroscopy
SOLEXA -
Revolution in
Bioinformatics
Now the beating
heart of Illumina
technology.
Acquired for US$
1billion or so.
Illumina now employ
600 people in
Cambridge.
Another Pub in the frontline of genetic and genomic discovery
ΦX174
Prof Sir Fred Sanger - 2 Nobel
prizes
1977
Sanger Method
for sequencing DNA
Human Genome Project
Historical Cost to sequence 1 entire human genome said to be $2.7bn
Today genome sequencing has been
super-accelerated and the cost
dramatically reduced. The Sanger
Centre - Wellcome Genome Centre leads
the world
Prof Sir Greg Winter Dr David Chiswell
1990
The revolution of using antibodies to create a whole new portfolio
of therapeutic medicines
• Combined headcount of technology providers currently exceeds 8,500 in UK
• PA Technology employs up to 3,500 Worldwide
• Combined direct and indirect revenues estimated at $3.0 billions – ? more
• PA technology – Revenues $750millions+ (estimate)
• Some players have seed funds
• 70 identified spin-outs - highly successful incubator models
Origins of the Cambridge Cluster and
Ecosystem
The Technology
Partnership
Scientific Generics Symbionics Team Consulting Plextek
P.A. Technology
Cambridge Consultants Ltd
(1960)
Cambridge University
And there have been more including Cambridge Design Partnership
The concept of Open Innovation and The Agora in practice
Hi-Tech Regions and Clusters - there are 50 and more
identified around the world where new economies have
developed. We are recalling how Cambridge became one and
looking at how it has developed.
Picture Dr Martin Hinoul - KU Leuven
What do we find in those regions and clusters?
And what about “Open Innovation” ?
“Open Innovation” and technological progress. Centres of
Open Innovation are amongst great Cluster Centres The
Internet has enabled Open Innovation ++++
Open Innovation flourishes in Cambridge
Concepts of partnership and sharing
in innovation - not just
competitiveness
Revolution 1991 !
The World Wide Web
Connectedness, Connectivity and
“Connectricity” and Open Innovation
How much
change has
the internet
and World
Wide Web
enabled?
How much
more is
possible?
Tim Berners-Lee
The Example everyone quotes of Hi-Tech Cluster and
Regional Innovative Ecosystem – “Silicon Valley”
There are stunning examples elsewhere - Cambridge is
one such
Role Models
Infrastructure
Looking more closely at “Clusters of Creativity for Growth” - Open
Innovation is at the heart of the growth of Technology Based Clusters
and Hi Tech Regions – where we find Common Characteristics....in
centres like those highlighted
• Knowledge Centers
• Entrepreneurs & Role Models
• Money
• Capital Markets
• Infrastructure
• Cluster Policy
• Presence of International
Companies
• Networks
• Government
• Quality of Life
Minds without Borders – Global
Mindset….and
Scale – Size – Populations 0.5
– 1 million common
Source Gibbons – Saxenian - Hinoul
We find Science, Technology and Knowledge
like theseThree Pervasive Technology Platforms in these centres
BIO TECH
Pharmaceuticals
Diagnostics
Research/Info
Tools
Industrial
Genomics
Bioinformatics
Proteomics
INFO TECH
Hardware
Software
Communications
NANO TECH
Electrical
Structural
Biomedical
Energy & Environment
Biosensors
BiochipsBioelectronics
Microfluidics
Nanobiotechnology
Drug Delivery
Nanodevices
Nanosensors
Nanoelectronics
Open Innovation
enables….
Transfer of
tacit
knowledge
Where the circles combine – enhanced prospects for innovation ++++.
Life Sciences cross technology boundaries these days. And Science
Parks and Innovation Centres are key elements in the development.
Professor Sir John Bradfield CBE Trinity College Cambridge
Founder Trinity Cambridge Science Park – First in Europe
Science Parks
in UK started
with an act of
faith by an
Ancient College
and set of a
trend in Europe
and Asia
Back in
Cambridge in
1970
Life Stage Locations
Business Park
Innovation CentreIncubator
Laboratory
Park
Genome
Campus
Serviced Office
Science Park
Facilities for Start-Up, Acceleration, Incubation,
Early Stage Development and Scale - up enable
technology cluster development. Support
positive change
Product Development Evolution
and the Money Supply Chain
From Idea to Marketplace
The Commercialisation of Research
The “Supply Chain of changing skill set needs” and the
“Supply Chain of ££££” needs to be planned and implemented
– with specific elements – for each enterprise and with each
phase in mind. And there are post launch phases.
Product Development Evolution
and the Money Supply Chain
From Idea to Marketplace
The Commercialisation of Research and Ideas
More on sources of finance later – but innovative companies
don’t exist in isolation – they often flourish in Clusters….
Little /no cost R&D POC Grants TSB Some EU Bus. Angels VC “A” Round VC “B” Round
“Catapult Centres” & Seed Funds
Sources Of Business Finance – The traditional view
Maturity
Risk
“Our Money”
Family and Friends
Fools
Business Angels
Early Stage VC
Expansion Capital
B
A
N
K
F
I
N
A
N
C
E
??
Seed Funds
Pre-IPO
Research Money from
numbers of streams
Grants for
companies – e.g.
Innovate UK, SBRI
European Union
Funds
But Entrepreneurial thinking and the internet are
changing the world – including the world of
Finance
The Developing World of Business and Enterprise Finance
“Alternative Finance”
 Impact of the Internet and Social Networks
A NEW world of communication and interaction
More “power to the people”
Impact of Innovation and Entrepreneurship
Failures of Western Banking System
Crowd Funding including Peer to Peer Lending
Impact Investing
“Collaborative Capitalism”
Microfinance
“A Brave NEW WORLD!”
Some speak of “The Democratisation of
access to Finance”
The Bradfield Centre Trinity Science Park Cambridge
600 places for start-up entrepreneurs – resident
coaches and mentors and connections with investors
Opened June 2017 – filling up ++++
State of the Art Innovation Centre
Now 25 Science Parks and Innovation
Centres in Greater Cambridge
And at Trinity Science Park we have a key investment
partner - TUS Park - Tsinghua University of Beijing
A £200 million investment in establishing a new
Bioscience Incubator - supporting local science and
technology and enabling internationalisation
Supporting Cambridge Science Park
Development and Growth
Connecting the Cambridge Cluster and
emerging technologies and companies with
Chinese opportunities
Science and Innovation Parks – Assets for participating
in a World Without Borders – Cambridge has made
progress – Platform for Global Growth and Wealth
Creation.
More science parks than in any other UK location - 25
• Babraham Bio-Incubator
• Cambridge Research Park
• Cambridge Science Park
• Granta Park
• Great Chesterford Research Park
• Melbourn Science Park
• St John’s Innovation Centre
• Peterhouse Science Park
• Biomedical Campus
Tenants include:
Toshiba Research Europe
Epson (UK) Ltd
Pfizer
Amgen Biosciences
Napp Pharmaceuticals
Genzyme Therapeutics Ltd
Astra Zeneca
GlaxoSmithKline
Takeda
Hitachi
Microsoft Research
Nokia
Philips Medical Research
Huawei (from China)
And more are planned –
Hauser Forum opened
2010 and Future
Business Centre 2014
Open Innovation needs Provision of space to support
serendipity, collaboration, networking and changemaking not
forgetting access to finance
The Hauser Forum and
IDEASPACE Cambridge
Thanks to Hermann and
his family trusts
Cambridge’s Centre for Social, Environmental
and Financial Impact
Home of Cambridge Cleantech
Working closely with Judge Business School
There are now three FBCs and more planned
1.From
Manual to
Mechanized
2. Then came
Automation
3. The DIGITAL Revolution – but maybe
NOT a “complete” revolution?
A Fourth Industrial Revolution ?
R&D Education
Applications
Companies
A Revolution of CONNECTEDNESS
A concept of “CONNECTRICITY”
Making possible a continuing Global Agora
Innovators, Educators, Practioners, Investors,
Policy Makers and Industry “joined up”!
Creating the
currents that
determine future
success
Energising the
connectivity of
people
Key Components of Entrepreneurial Eco-system – Local start-ups
and inward migration – as the Culture changed
Cambridge
University
1960
1970
MRC
Laboratory
of Molecular
Biology
CAD
Centre
Sinclair
Radionics
CCL
Barclays Bank
1980
Cambridge
Interactive
System
Cambridge
Science Park
Acorn
PA
Technology
Eicon
Research Ltd
Sinclair
Research Ltd
1990
Analysys
Olivetti Research
Laboratory
(acquired by
AT&T in 1999)
Judge Business
School
St. John
Innovation
Centre
Scientific
Generics
The Technology
Partnership
TTP
Cambridge Research and
Innovation Ltd (CRIL)
Institute of
Biotechnolog
y
Cantab
Pharmaceuticals
Hitachi
Cambridge
Laboratory
Nickerson
Biotech
Laboratory
Glaxo
2000
Toshiba
Cambridge
Research
Laboratory
Seiko Epson
Research
Lab
Unilever Cambridge
Centre for Molecular
Informatics
Cambridge
Network
Institute of
Manufacturing
Amadeus Capital
Partners
TTP Ventures
Microsoft Research
(previously Entropic
Research)
Glaxo Institute
of Applied
Pharmacology
BP
CfEL (previously
CEC)
Cambridge
Enterprise
CUE, Biology
in Business
CMI
Avlar
ET Capital
Cambridge
Gateway
3i Create
Partners
Cambridge
Angels
GEIF
Library
House
Cambridge
Capital Group
ERBI
Philip
s
EPSON
The Wellcome
Trust Sanger
Babraham
Bioincubator
Cambridge
Research
Park
Granta Park
CHASE
Enterprise Link
Huawei 2015
“Brain Circulation and Knowledge
Sharing Across Borders and
Functions”
“Open Innovation Thinking” and Action
From local to global - making big change happen in turning
knowledge into real things - within the context we have described.
How has Cambridge culture evolved?
Starting with MINDSET – Belief in “A World Without
Borders” encourage everyone to “Worldthink”
Case Study: Barclays Bank – Eagle Lab
A recent development
Barclays
• Established in 1690, is the oldest bank in the UK
• One of the largest financial institutes worldwide
• Greatly supports consumers and SMEs
Case Study: Barclays Bank – Eagle Lab
- Economic flexible space for early stage
entrepreneurs
- Connected with local investors, mentors and
coaches
- Convenient city centre locations
- Direct connections with other innovation centres
and science parks
17 more planned
Why Barclay doing it?
• Attract tomorrow’s client
• Strengthen the core technology capability
Case Study: Barclays Bank – Eagle Lab
Fab Labs
Case Study: Barclays Bank – Eagle Lab
Strategic Transformation Director, Barclays
Steven Roberts
PhD in Geophysics, Cambridge University
Case Study: Barclays Bank – Eagle Lab
Prof. Alan Barrell is a Barclays Eagle Labs’ coach, mentor and supporter from day one
People Factors - Knowledge and Communication are fine but
what more should we consider….?
“IMAGINATION” – said Einstein – “and it is more
important than knowledge. Knowledge is limited
– Imagination encircles the World”
“You look at things
and ask - why?
but I dream of things
that never were and
ask….
George Bernard Shaw
why not?”
And Entrepreneurship - said to be such a key
element in Cambridge - can we agree a definition?
All the great Leaders and change
agents who have “made a
difference” have been “Why Not”
people. Entrepreneurship is a
mindset. They didn’t say or think
“yes but”
The emergence of high-technology clusters in
Greater Cambridge – The Transformation
50,000
This slide was made
in 2004. “The Future”
had become reality by
2014
60,000
Not to overlook the key role of Marshall
Group over the whole period. A bedrock of
engineering excellence and education of
talent.
The Cambridge Cluster -An example of “Bottom Up” – not
“Top Down” Growth and Development….my view….
Building communities of enterprise,
social inclusion and common
purpose. With International Mindset
Sub-regional development
Regional economic development
National Economy – World
Economy
A Joined Up System and Society
Connectedness, connectivity and connectricity
Cambridge is only one example of the development of a
“Cluster of Creativity”
Cross-sector collaboration
And “convergence” connects industry sectors and scientific / technical
disciplines - Cambridge Connectivity
Basis of an effective “joined-up” Entrepreneurial Ecosystem
Thanks to The Cambridge Network
Importance of intermingling and “connecting”
Key role of “The Cambridge Network Ltd” –
www.cambridgenetwork.co.uk – formed 20years ago
Importance of ENABLING networking
The Cambridge environment provides many
and different opportunities for knowledge
exchange
Collaboration between R&D and
Technology Commercialisation
Centres of Excellence – jointly
funded
International
Collaborations with
TOP Partners is a
BIG PLUS
We have benefitted from supported international collaborations
Latest News – Astra Zeneca relocating Headquarters and
R&D on Cambridge Biomedical Campus – 2,200 new jobs !
 Alcatel Lucent
 Amgen
 AstraZeneca
 Bayer
 Broadcom
 Cancer Research
 Citrix
 Genzyme
 GSK
 Hitachi
 Illumina
 Intel
 Medical Research Council
 Microsoft Research
 Napp
 Pfizer
 Philips
 Qualcom
 SOBI
 Takeda
 Toshiba
 Wellcome Trust
 Huawei –China
FDI - Significant Organisations investing in
Cambridge - inspired by the cluster
2018 £200m - Tsinghua University in
Cambridge Science Park - for Biocentre
and Ten Cents £17m in Frontier Games
And Huawei is a major investor -
a dilemma….
Astra Zeneca Global Headquarters
Biomedical Campus Cambridge
The Campus will be the largest in Europe
Global centre for Medical and
Pharmaceutical Research
Looking a little further ahead at the Biomedical Campus
Europe’s largest and fastest growing Bioscience Campus
The Huawei Dilemma - Cambridge is a key player with
Huawei and Huawei represents a geopolitical conundrum
 Huawei acquired Neul - for £25m. Now a European R&D Centre
 2019 acquired old Spicer Sawston site for £35m
 Planning a factory for 400 employees - major new investment
 Huawei is committed to Cambridge Community - Board
membership Cambridge Wireless Network
Art and Creativity pervade life in Cambridge and are part of “The
Phenomenon” - Science and Technology are not ALL.
The School of Art, now within ARU has a great history - and
Cambridge Societies such as Cambridge Drawing Society and
Watercolourists are supremely enterprising.
Cambridge Drawing
Society Founded 1882
and still going strong
Regular exhibitions in
public centres. Lots of
information on the
website -
www.cambridgedrawingso
ciety.org
Games Industry - Jagex - Chinese investments
Frontier Technology and Elite Game.
£17m invested by TenCent of China
Anglia Ruskin University - not to be forgotten - has the REACTOR International
Digital Games Incubator - and great expertise. And ARU still has School of Art
The Computer Games
Industry brings
Creativity, Art, Design
and Technology
together
And one of the world’s great Chocolate companies
was born here!
Having a Cocoa Plantation and stores and cafes
everywhere!
Cambridge today has 18 companies valued at more than
US$ 1billion - 2 at $10billion and 1 at $30billion
Cambridge Economy growing at 9% We have see much
being changed.
Cambridge Innovation Capital - University Venture
Fund - £200 millions
More inward bound venture investment than any
other centre - US 1 billion in past year
Every smartphone in the world
contains at least one chip
designed by ARM.
More than 86 BILLION ARM-based
chips have been shipped (Sept 2016).
The phenomenon of ARM Holdings - world leading “chip” designer.
The biggest of Cambridge technology companies
Origins in Acorn - new paradigm company - design not make -
license to the world.
“We develop
business
opportunities
obtain
resources,
manage
contracts…..
And provide
financial
support from
proof of
concept to
exit” through
Cambridge
Innovation
Capital
The Commercialisation of Research
Imagination Innovation and
Entrepreneurship
The DNA of human progress
Cambridge as a New Age Agora
Joining-up, Connectedness and
“Connectricity”
Celebrating “The Cambridge Phenomenon”
But…….
Downsides and challenges of Growth and Success
Some issues….
 History, conservation and preservation in a great ancient city
 Population growth and congestion - environmental challenge
 Challenge of uncontrolled tourism
 Property prices and affordable accommodation
 Cambridge, Peterborough and Regional Politics and the Regional
Economy
 Decision making and policy in a small city - global centre
 No easy decisions - we will reflect when he conclude by looking
ahead
A brief look at future possibilities
Smart Agora Cambridge
Technology and Innovation will contribute
++++
The Challenges
Can future growth and development be
balanced and embrace human and
societal issues ?
Looking ahead - changes in the Business and Working World are
accelerating faster and with technological advances - more than ever before.
Cambridge is well positioned for technological leadership
87
Where are great advances being made in scientific and technical or
engineering discovery? Applying “Tomorrow’s Innovations” Where will
we be initiating positive change in future?”
 Genetics, Genomics, Biomics,”Multiomics”
 Biomedicine including Regenerative Medicine
 Imaging
 Materials Science
 Nanotechnology
 Sustainable Chemistry
 Agritech – Agricultural Science and Technology
 Computer Science Generally
 Artificial Intelligence
 Machine Learning
 Big Data
 Virtual and Augmented Reality
 Robotics
 Space Exploration
Areas where we can actually bring about
change.
One example area - Digital Healthcare and Medical Education – Leading Edge
Digital Healthcare possibilities are huge
The Future Here and Now
Artificial Intelligence and Machine Learning - significant
areas for future progress
Cambridge University and Cambridge companies
aligned for progress and leadership
The fascinating questions about “men,
women and machines”
Artificial intelligence, Machine Learning and Robotics
the contribution of Cambridge science and
technology. But many questions to be answered….
Intriguing challenges of Robotics
Perhaps a step too far?...........
To be very serious….key progress in Cambridge….
Cambridge Medical Robotics - CMR - establishing
world leadership
What about those problem areas - are there plans in place?
Greater Cambridge Partnership has ambitious plans
Growth in Greater Cambridge
20
Companies
listed on
the stock market
10.5
%
Growth in
turnover
for tech sector
10.4
%
Growth in
turnover
for life sciences
£4bn
Economic output
Ambition by
2043
Skills Smart
• Greater Cambridge
Apprenticeships service launched
in July 2019
• New service aims to create 420 new
apprenticeships across Greater Cambridge
• Service to help businesses identify how they
could take on apprentices to fill skills gaps
and give apprentices access to STEM roles.
• Form the Future and Cambridge Regional
College managing service on GCP’s behalf.
• SmartPanels and Wayfinding screens at
Cambridge Station and public buildings
• MotionMap app and Pocket SmartPanel –
real time journeys
• Autonomous shuttle trials due in 2020
• Air quality & traffic monitoring in Cambridge
• Intelligent mobility – research on first/last
mile journeys, customer experience and
traffic management
Cambridgeshire Autonomous
Metro – network map
Two wonderful books about “The Cambridge Phenomenon”
Thanks to Kate Kirk and Charles Cotton
A final reminder - NOT my most recent class of students - but
the reminder I end my student lectures with - because Einstein’s
advice about Imagination is so important! And to end with a
smile….
“Imagination is more important than Knowledge” – Albert Einstein
One of the secrets of “The Cambridge Phenomenon”
Thank You for Listening
alan@alanbarrell.com
www.alanbarrell.com

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The Cambridge Phenomenon - Professor Alan Barrell

  • 1. The Cambridge Phenomenon 50 Years of Innovation and Enterprise The Cambridge Phenomenon The evolution of an Entrepreneurial Ecosystem Story of a Progression towards Open Innovation and a Culture embracing Connected Interests - a story still unfolding - and a personal set of thoughts - not an academic paper. Focus on people. Professor Alan Barrell
  • 2. Relating to History and visionary romance - starting with the concept of the Agora of Ancient Athens about 600 BC A special central place for all and everything - meeting, greeting, eating, exchanging, learning - voting. Birthplace of the Athenian Democratic Process. Politicians, philosophers, criminals, traders, aristocrats, scientists, officials and slaves - all passed through and made contact there. A model of an epicentre of knowledge sharing. Does Cambridge represent a Agora for today and tomorrow?
  • 3. Great minds “brainstorming” in the Agora at Athens Fresco by Raphael - now in The Vatican Scientific Theory - not called by that name then- got started in the Agora sessions. Socrates, Plato and Aristotle and others met, socialised, philosophised and instructed students here. Perhaps we see parallels in Cambridge today?
  • 4. Living Longer – not always Healthier – big dilemma World Population 1953 3.5 billions : 2014 7.5 billions : 2025 - ? 10 billions…. There is another Context to our Cambridge Story – Our World Today – Reminders – Challenges Climate Change and Energy Food and Water Seismic Changes in World Economy The Century of Science and Technology A “New Renaissance” – Age of Education – Example - 8.3million new graduates in China in 2018 BIG Opportunities for creative R&D, Businesses and Entrepreneurs
  • 5. Getting back to Cambridge - amidst these tranquil surroundings….. great Centre of Learning ….and the story of an economic transformation
  • 6. 800 years + of academic excellence
  • 7. The Cambridge Phenomenon Attracting global interest and admiration - local pride and local concerns. Innovation and change are mixed blessings
  • 8. Population of Cambridge approx. 130,000 Of which, around 25,000 are students Reminder - Cambridge is a very small city “Greater Cambridge” sub region 650,000 East of England Region 6.5 million
  • 9. 52 107 More Nobel prize winners than most countries (and Oxford!) Always a risk my numbers will be out of date!
  • 10. Cambridge and the Eastern Region – a Transformation Regional Example – the last 60 years Traditional Industries •Agriculture and Food •Fishing •Leather goods - Footwear •Wool and Textiles •6.5 million people now •Now One of UKs fastest growing regions in Europe •Traditional Industries dead, dying or gone away…. 60 years ago – this was a deprived and declining region. University has played a key role in recovery Worstead and Thetford in Norfolk - Centres of the First Great Wool Trade Last reported annual growth 9%!
  • 11. Cambridge Ideas have changed the World….but regional economic development did not follow….for centuries Ideas that Changed the World – not historically to the great benefit of Cambridge, the Region or the Nation…. R&D alone doesn’t create wealth or social good. R&D is NOT innovation But Cambridge has had Innovators - some examples of wonderful changemakers….
  • 12. Mathematics and the start of “computer thinking” Charles Babbage – Cambridge man and some say “father and mother of computing”
  • 13. Babbage’s “Difference Machine” – 1880 – Cambridge “Difference Calculating Machine”
  • 14. Ada Lovelace – illegitimate daughter of Lord Byron World’s first computer programmer?
  • 15. Ada’s Algorithms. That is what we would call them today
  • 16. Oh for a laptop! What would she have achieved? Admired and feted by Prince Albert
  • 17. And somewhat later - mainframe computing and the EDSAC - world leadership in Cambridge Sir Maurice Wilkes hero of computer science and design
  • 19. A history of true invention and creativity EDSAC in the 1940s
  • 20. The Maurice Wilkes Building at St John’s Innovation Centre Not only in memory - but enabling future inventions and technology development
  • 21. From Babbage and his “Difference machine”through Wilkes and others from 1880 - to Raspberry Pi 2012– a leap in time, technology, size and scale. Jack Lang, first Chairman Raspberry Pi Foundation. Computer Programming for ALL
  • 22. Raspberry Pi a revolution in scale , power and cost It is TINY……as shown by co- founder Dr David Braben here But POWERFUL ! Big Data from Tiny Devices
  • 23. 25 million Raspberry Pi computers sold ( ByFebruary 2019) Changing the world and enabling thousands to benefit. Myriads of applications.
  • 24. Long before Raspberry Pi - Alan Turing - Code breaker and computer science leader in WW 2 and father of Artificial Intelligence A hero and visionary - unrecognised and very badly treated in his own lifetime. Kings College Cambridge. Today we have The Turing Institute and his contribution acknowledged.
  • 25. More world changing science – “Cambridge Ideas Change the World” 1953 Crick and Watson – Double Helix – DNA 1953 Great Bioscience discoveries in a Physics Lab. - The Cavendish - more great names to recall - Rutherford, JJ Thomson, Bragg, Clerk-Maxwell, Mott, Max Perutz and more
  • 26. DNA Crick and Watson 1953 at Old Cavendish Labs And across the street….a friendly pub - with the best beer….
  • 27. The Eagle Pub - where it is reported Crick and Watson first reported one of the greatest discoveries in the history of science - DNA - The Double - “The Secret of Life” Enjoy a glass of “DNA ALE” there anytime….
  • 28. The house that Crick lived in 20 Portugal Place with Double Helix
  • 29. The Francis Crick Institute – Leading Edge Medical Research World class teams connected with other leaders in other UK and International Centres – breaking new ground in Cancer Research and other key areas
  • 30. Lest we forget - The Double Helix discovery was possible through the work of Rosalind Franklin An untimely death, politics and other factors deprived her of the recognition she deserved and deserves.
  • 31. Shankar Balasubramanian and David Klenerman DNA polymerase and laser spectroscopy SOLEXA - Revolution in Bioinformatics Now the beating heart of Illumina technology. Acquired for US$ 1billion or so. Illumina now employ 600 people in Cambridge. Another Pub in the frontline of genetic and genomic discovery
  • 32. ΦX174 Prof Sir Fred Sanger - 2 Nobel prizes 1977 Sanger Method for sequencing DNA
  • 33. Human Genome Project Historical Cost to sequence 1 entire human genome said to be $2.7bn Today genome sequencing has been super-accelerated and the cost dramatically reduced. The Sanger Centre - Wellcome Genome Centre leads the world
  • 34. Prof Sir Greg Winter Dr David Chiswell 1990 The revolution of using antibodies to create a whole new portfolio of therapeutic medicines
  • 35. • Combined headcount of technology providers currently exceeds 8,500 in UK • PA Technology employs up to 3,500 Worldwide • Combined direct and indirect revenues estimated at $3.0 billions – ? more • PA technology – Revenues $750millions+ (estimate) • Some players have seed funds • 70 identified spin-outs - highly successful incubator models Origins of the Cambridge Cluster and Ecosystem The Technology Partnership Scientific Generics Symbionics Team Consulting Plextek P.A. Technology Cambridge Consultants Ltd (1960) Cambridge University And there have been more including Cambridge Design Partnership
  • 36. The concept of Open Innovation and The Agora in practice Hi-Tech Regions and Clusters - there are 50 and more identified around the world where new economies have developed. We are recalling how Cambridge became one and looking at how it has developed. Picture Dr Martin Hinoul - KU Leuven What do we find in those regions and clusters? And what about “Open Innovation” ?
  • 37. “Open Innovation” and technological progress. Centres of Open Innovation are amongst great Cluster Centres The Internet has enabled Open Innovation ++++ Open Innovation flourishes in Cambridge Concepts of partnership and sharing in innovation - not just competitiveness
  • 38. Revolution 1991 ! The World Wide Web Connectedness, Connectivity and “Connectricity” and Open Innovation How much change has the internet and World Wide Web enabled? How much more is possible? Tim Berners-Lee
  • 39. The Example everyone quotes of Hi-Tech Cluster and Regional Innovative Ecosystem – “Silicon Valley” There are stunning examples elsewhere - Cambridge is one such
  • 40. Role Models Infrastructure Looking more closely at “Clusters of Creativity for Growth” - Open Innovation is at the heart of the growth of Technology Based Clusters and Hi Tech Regions – where we find Common Characteristics....in centres like those highlighted • Knowledge Centers • Entrepreneurs & Role Models • Money • Capital Markets • Infrastructure • Cluster Policy • Presence of International Companies • Networks • Government • Quality of Life Minds without Borders – Global Mindset….and Scale – Size – Populations 0.5 – 1 million common Source Gibbons – Saxenian - Hinoul
  • 41. We find Science, Technology and Knowledge like theseThree Pervasive Technology Platforms in these centres BIO TECH Pharmaceuticals Diagnostics Research/Info Tools Industrial Genomics Bioinformatics Proteomics INFO TECH Hardware Software Communications NANO TECH Electrical Structural Biomedical Energy & Environment Biosensors BiochipsBioelectronics Microfluidics Nanobiotechnology Drug Delivery Nanodevices Nanosensors Nanoelectronics Open Innovation enables…. Transfer of tacit knowledge Where the circles combine – enhanced prospects for innovation ++++. Life Sciences cross technology boundaries these days. And Science Parks and Innovation Centres are key elements in the development.
  • 42. Professor Sir John Bradfield CBE Trinity College Cambridge Founder Trinity Cambridge Science Park – First in Europe Science Parks in UK started with an act of faith by an Ancient College and set of a trend in Europe and Asia Back in Cambridge in 1970
  • 43. Life Stage Locations Business Park Innovation CentreIncubator Laboratory Park Genome Campus Serviced Office Science Park Facilities for Start-Up, Acceleration, Incubation, Early Stage Development and Scale - up enable technology cluster development. Support positive change
  • 44. Product Development Evolution and the Money Supply Chain From Idea to Marketplace The Commercialisation of Research The “Supply Chain of changing skill set needs” and the “Supply Chain of ££££” needs to be planned and implemented – with specific elements – for each enterprise and with each phase in mind. And there are post launch phases.
  • 45. Product Development Evolution and the Money Supply Chain From Idea to Marketplace The Commercialisation of Research and Ideas More on sources of finance later – but innovative companies don’t exist in isolation – they often flourish in Clusters…. Little /no cost R&D POC Grants TSB Some EU Bus. Angels VC “A” Round VC “B” Round “Catapult Centres” & Seed Funds
  • 46. Sources Of Business Finance – The traditional view Maturity Risk “Our Money” Family and Friends Fools Business Angels Early Stage VC Expansion Capital B A N K F I N A N C E ?? Seed Funds Pre-IPO Research Money from numbers of streams Grants for companies – e.g. Innovate UK, SBRI European Union Funds But Entrepreneurial thinking and the internet are changing the world – including the world of Finance
  • 47. The Developing World of Business and Enterprise Finance “Alternative Finance”  Impact of the Internet and Social Networks A NEW world of communication and interaction More “power to the people” Impact of Innovation and Entrepreneurship Failures of Western Banking System Crowd Funding including Peer to Peer Lending Impact Investing “Collaborative Capitalism” Microfinance “A Brave NEW WORLD!” Some speak of “The Democratisation of access to Finance”
  • 48. The Bradfield Centre Trinity Science Park Cambridge 600 places for start-up entrepreneurs – resident coaches and mentors and connections with investors Opened June 2017 – filling up ++++ State of the Art Innovation Centre Now 25 Science Parks and Innovation Centres in Greater Cambridge
  • 49. And at Trinity Science Park we have a key investment partner - TUS Park - Tsinghua University of Beijing A £200 million investment in establishing a new Bioscience Incubator - supporting local science and technology and enabling internationalisation
  • 50. Supporting Cambridge Science Park Development and Growth Connecting the Cambridge Cluster and emerging technologies and companies with Chinese opportunities
  • 51. Science and Innovation Parks – Assets for participating in a World Without Borders – Cambridge has made progress – Platform for Global Growth and Wealth Creation. More science parks than in any other UK location - 25 • Babraham Bio-Incubator • Cambridge Research Park • Cambridge Science Park • Granta Park • Great Chesterford Research Park • Melbourn Science Park • St John’s Innovation Centre • Peterhouse Science Park • Biomedical Campus Tenants include: Toshiba Research Europe Epson (UK) Ltd Pfizer Amgen Biosciences Napp Pharmaceuticals Genzyme Therapeutics Ltd Astra Zeneca GlaxoSmithKline Takeda Hitachi Microsoft Research Nokia Philips Medical Research Huawei (from China) And more are planned – Hauser Forum opened 2010 and Future Business Centre 2014
  • 52. Open Innovation needs Provision of space to support serendipity, collaboration, networking and changemaking not forgetting access to finance The Hauser Forum and IDEASPACE Cambridge Thanks to Hermann and his family trusts
  • 53. Cambridge’s Centre for Social, Environmental and Financial Impact Home of Cambridge Cleantech Working closely with Judge Business School There are now three FBCs and more planned
  • 54. 1.From Manual to Mechanized 2. Then came Automation 3. The DIGITAL Revolution – but maybe NOT a “complete” revolution?
  • 55. A Fourth Industrial Revolution ? R&D Education Applications Companies A Revolution of CONNECTEDNESS A concept of “CONNECTRICITY” Making possible a continuing Global Agora Innovators, Educators, Practioners, Investors, Policy Makers and Industry “joined up”! Creating the currents that determine future success Energising the connectivity of people
  • 56. Key Components of Entrepreneurial Eco-system – Local start-ups and inward migration – as the Culture changed Cambridge University 1960 1970 MRC Laboratory of Molecular Biology CAD Centre Sinclair Radionics CCL Barclays Bank 1980 Cambridge Interactive System Cambridge Science Park Acorn PA Technology Eicon Research Ltd Sinclair Research Ltd 1990 Analysys Olivetti Research Laboratory (acquired by AT&T in 1999) Judge Business School St. John Innovation Centre Scientific Generics The Technology Partnership TTP Cambridge Research and Innovation Ltd (CRIL) Institute of Biotechnolog y Cantab Pharmaceuticals Hitachi Cambridge Laboratory Nickerson Biotech Laboratory Glaxo 2000 Toshiba Cambridge Research Laboratory Seiko Epson Research Lab Unilever Cambridge Centre for Molecular Informatics Cambridge Network Institute of Manufacturing Amadeus Capital Partners TTP Ventures Microsoft Research (previously Entropic Research) Glaxo Institute of Applied Pharmacology BP CfEL (previously CEC) Cambridge Enterprise CUE, Biology in Business CMI Avlar ET Capital Cambridge Gateway 3i Create Partners Cambridge Angels GEIF Library House Cambridge Capital Group ERBI Philip s EPSON The Wellcome Trust Sanger Babraham Bioincubator Cambridge Research Park Granta Park CHASE Enterprise Link Huawei 2015
  • 57. “Brain Circulation and Knowledge Sharing Across Borders and Functions” “Open Innovation Thinking” and Action From local to global - making big change happen in turning knowledge into real things - within the context we have described. How has Cambridge culture evolved? Starting with MINDSET – Belief in “A World Without Borders” encourage everyone to “Worldthink”
  • 58. Case Study: Barclays Bank – Eagle Lab A recent development Barclays • Established in 1690, is the oldest bank in the UK • One of the largest financial institutes worldwide • Greatly supports consumers and SMEs
  • 59. Case Study: Barclays Bank – Eagle Lab - Economic flexible space for early stage entrepreneurs - Connected with local investors, mentors and coaches - Convenient city centre locations - Direct connections with other innovation centres and science parks 17 more planned
  • 60. Why Barclay doing it? • Attract tomorrow’s client • Strengthen the core technology capability Case Study: Barclays Bank – Eagle Lab Fab Labs
  • 61. Case Study: Barclays Bank – Eagle Lab Strategic Transformation Director, Barclays Steven Roberts PhD in Geophysics, Cambridge University
  • 62. Case Study: Barclays Bank – Eagle Lab Prof. Alan Barrell is a Barclays Eagle Labs’ coach, mentor and supporter from day one
  • 63. People Factors - Knowledge and Communication are fine but what more should we consider….? “IMAGINATION” – said Einstein – “and it is more important than knowledge. Knowledge is limited – Imagination encircles the World”
  • 64. “You look at things and ask - why? but I dream of things that never were and ask…. George Bernard Shaw why not?” And Entrepreneurship - said to be such a key element in Cambridge - can we agree a definition? All the great Leaders and change agents who have “made a difference” have been “Why Not” people. Entrepreneurship is a mindset. They didn’t say or think “yes but”
  • 65. The emergence of high-technology clusters in Greater Cambridge – The Transformation 50,000 This slide was made in 2004. “The Future” had become reality by 2014 60,000 Not to overlook the key role of Marshall Group over the whole period. A bedrock of engineering excellence and education of talent.
  • 66. The Cambridge Cluster -An example of “Bottom Up” – not “Top Down” Growth and Development….my view…. Building communities of enterprise, social inclusion and common purpose. With International Mindset Sub-regional development Regional economic development National Economy – World Economy
  • 67. A Joined Up System and Society Connectedness, connectivity and connectricity Cambridge is only one example of the development of a “Cluster of Creativity”
  • 68. Cross-sector collaboration And “convergence” connects industry sectors and scientific / technical disciplines - Cambridge Connectivity Basis of an effective “joined-up” Entrepreneurial Ecosystem Thanks to The Cambridge Network
  • 69. Importance of intermingling and “connecting” Key role of “The Cambridge Network Ltd” – www.cambridgenetwork.co.uk – formed 20years ago Importance of ENABLING networking
  • 70. The Cambridge environment provides many and different opportunities for knowledge exchange
  • 71. Collaboration between R&D and Technology Commercialisation Centres of Excellence – jointly funded International Collaborations with TOP Partners is a BIG PLUS We have benefitted from supported international collaborations
  • 72. Latest News – Astra Zeneca relocating Headquarters and R&D on Cambridge Biomedical Campus – 2,200 new jobs !  Alcatel Lucent  Amgen  AstraZeneca  Bayer  Broadcom  Cancer Research  Citrix  Genzyme  GSK  Hitachi  Illumina  Intel  Medical Research Council  Microsoft Research  Napp  Pfizer  Philips  Qualcom  SOBI  Takeda  Toshiba  Wellcome Trust  Huawei –China FDI - Significant Organisations investing in Cambridge - inspired by the cluster 2018 £200m - Tsinghua University in Cambridge Science Park - for Biocentre and Ten Cents £17m in Frontier Games And Huawei is a major investor - a dilemma….
  • 73. Astra Zeneca Global Headquarters Biomedical Campus Cambridge The Campus will be the largest in Europe Global centre for Medical and Pharmaceutical Research
  • 74. Looking a little further ahead at the Biomedical Campus Europe’s largest and fastest growing Bioscience Campus
  • 75. The Huawei Dilemma - Cambridge is a key player with Huawei and Huawei represents a geopolitical conundrum  Huawei acquired Neul - for £25m. Now a European R&D Centre  2019 acquired old Spicer Sawston site for £35m  Planning a factory for 400 employees - major new investment  Huawei is committed to Cambridge Community - Board membership Cambridge Wireless Network
  • 76. Art and Creativity pervade life in Cambridge and are part of “The Phenomenon” - Science and Technology are not ALL. The School of Art, now within ARU has a great history - and Cambridge Societies such as Cambridge Drawing Society and Watercolourists are supremely enterprising.
  • 77. Cambridge Drawing Society Founded 1882 and still going strong Regular exhibitions in public centres. Lots of information on the website - www.cambridgedrawingso ciety.org
  • 78. Games Industry - Jagex - Chinese investments Frontier Technology and Elite Game. £17m invested by TenCent of China Anglia Ruskin University - not to be forgotten - has the REACTOR International Digital Games Incubator - and great expertise. And ARU still has School of Art The Computer Games Industry brings Creativity, Art, Design and Technology together
  • 79. And one of the world’s great Chocolate companies was born here! Having a Cocoa Plantation and stores and cafes everywhere!
  • 80. Cambridge today has 18 companies valued at more than US$ 1billion - 2 at $10billion and 1 at $30billion Cambridge Economy growing at 9% We have see much being changed. Cambridge Innovation Capital - University Venture Fund - £200 millions More inward bound venture investment than any other centre - US 1 billion in past year
  • 81. Every smartphone in the world contains at least one chip designed by ARM. More than 86 BILLION ARM-based chips have been shipped (Sept 2016). The phenomenon of ARM Holdings - world leading “chip” designer. The biggest of Cambridge technology companies Origins in Acorn - new paradigm company - design not make - license to the world.
  • 82. “We develop business opportunities obtain resources, manage contracts….. And provide financial support from proof of concept to exit” through Cambridge Innovation Capital The Commercialisation of Research
  • 83. Imagination Innovation and Entrepreneurship The DNA of human progress Cambridge as a New Age Agora Joining-up, Connectedness and “Connectricity” Celebrating “The Cambridge Phenomenon” But…….
  • 84. Downsides and challenges of Growth and Success Some issues….  History, conservation and preservation in a great ancient city  Population growth and congestion - environmental challenge  Challenge of uncontrolled tourism  Property prices and affordable accommodation  Cambridge, Peterborough and Regional Politics and the Regional Economy  Decision making and policy in a small city - global centre  No easy decisions - we will reflect when he conclude by looking ahead
  • 85. A brief look at future possibilities Smart Agora Cambridge Technology and Innovation will contribute ++++ The Challenges Can future growth and development be balanced and embrace human and societal issues ?
  • 86. Looking ahead - changes in the Business and Working World are accelerating faster and with technological advances - more than ever before. Cambridge is well positioned for technological leadership
  • 87. 87 Where are great advances being made in scientific and technical or engineering discovery? Applying “Tomorrow’s Innovations” Where will we be initiating positive change in future?”  Genetics, Genomics, Biomics,”Multiomics”  Biomedicine including Regenerative Medicine  Imaging  Materials Science  Nanotechnology  Sustainable Chemistry  Agritech – Agricultural Science and Technology  Computer Science Generally  Artificial Intelligence  Machine Learning  Big Data  Virtual and Augmented Reality  Robotics  Space Exploration Areas where we can actually bring about change.
  • 88. One example area - Digital Healthcare and Medical Education – Leading Edge Digital Healthcare possibilities are huge The Future Here and Now
  • 89. Artificial Intelligence and Machine Learning - significant areas for future progress Cambridge University and Cambridge companies aligned for progress and leadership
  • 90. The fascinating questions about “men, women and machines” Artificial intelligence, Machine Learning and Robotics the contribution of Cambridge science and technology. But many questions to be answered….
  • 92. Perhaps a step too far?........... To be very serious….key progress in Cambridge….
  • 93. Cambridge Medical Robotics - CMR - establishing world leadership
  • 94. What about those problem areas - are there plans in place?
  • 95. Greater Cambridge Partnership has ambitious plans
  • 96. Growth in Greater Cambridge 20 Companies listed on the stock market 10.5 % Growth in turnover for tech sector 10.4 % Growth in turnover for life sciences £4bn Economic output Ambition by 2043
  • 97. Skills Smart • Greater Cambridge Apprenticeships service launched in July 2019 • New service aims to create 420 new apprenticeships across Greater Cambridge • Service to help businesses identify how they could take on apprentices to fill skills gaps and give apprentices access to STEM roles. • Form the Future and Cambridge Regional College managing service on GCP’s behalf. • SmartPanels and Wayfinding screens at Cambridge Station and public buildings • MotionMap app and Pocket SmartPanel – real time journeys • Autonomous shuttle trials due in 2020 • Air quality & traffic monitoring in Cambridge • Intelligent mobility – research on first/last mile journeys, customer experience and traffic management
  • 99. Two wonderful books about “The Cambridge Phenomenon” Thanks to Kate Kirk and Charles Cotton
  • 100. A final reminder - NOT my most recent class of students - but the reminder I end my student lectures with - because Einstein’s advice about Imagination is so important! And to end with a smile…. “Imagination is more important than Knowledge” – Albert Einstein One of the secrets of “The Cambridge Phenomenon”
  • 101. Thank You for Listening alan@alanbarrell.com www.alanbarrell.com