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SumiShield® 50WG is an Indoor
Residual Spray (IRS) product
containing a new mode of action
active ingredient for use in
ve...
•  Increasing resistance to all 4 classes
(pyrethroids, carbamates, organophosphates and
organochlorines) of IRS insectici...
Because of increased resistance to existing insecticides there is
a great need for an insecticide with a new mode of actio...
The major objective for Sumitomo Chemical was to develop a new IRS product that would not be resisted by mosquitoes
which ...
SumiShield 50WG is odourless, has low
toxicity, readily dilutes in water, and is
easy to transport. New mode of action
mak...
SumiShield 50WG has been developed for IRS application - to be sprayed to the inside of houses, walls and other
substrates...
Handling
Use only in well ventilated areas. Wash thoroughly
with soap and water after handling and before eating,
drinking...
Technical specifications
Active Ingredient: Clothianidin 50.0% (w/w)
Other Ingredients: 50.0%
Total 100.0%
Nitroguanidine ...
1. Wall Bioassay Results
Experimental huts were used for the trials and SumiShield 50WG was applied with a compression spr...
Biological Efficacy (2)
Comment
It can be seen in Figure 1 (see previous slide) that kill against
susceptible Kisumu strai...
2. Wild Mosquitoes Entering Experimental Huts
Comment
The local wild mosquitoes are naturally resistant to most
insecticid...
Biological Efficacy (4)
Resistance to at least one insecticide
has been identified in 64 countries with
on-going malaria t...
According to the EPA, clothianidin is
practically non-toxic to selected test bird
species that were fed relatively large d...
Acute oral LD50: LD50 is 3900mg/kg body weight (bw) for males and 4700mg/kg bw for females.
Skin and eye: Very slight (bar...
www.sumivector.com
© 2015 Sumitomo Chemical Company Ltd.
SumiShield® is a registered trademark of
Sumitomo Chemical Compan...
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Sumishield Product

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Sumishield Product Powerpoint

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Sumishield Product

  1. 1. SumiShield® 50WG is an Indoor Residual Spray (IRS) product containing a new mode of action active ingredient for use in vector control. SumiShield provides excellent control of malaria transmitting mosquitoes and is especially valuable when used in insecticide resistance management strategies.
  2. 2. •  Increasing resistance to all 4 classes (pyrethroids, carbamates, organophosphates and organochlorines) of IRS insecticides. •  Great need for new insecticides for resistance management and rotational programs. •  No new mode of action (MOA) IRS product for 40 years. •  Sumitomo Chemical identified the neonicotinoid clothianidin - Lab and field trials have shown great promise. •  SumiShield 50WG submitted to WHOPES in 2014. Introduction and Background
  3. 3. Because of increased resistance to existing insecticides there is a great need for an insecticide with a new mode of action. SumiShield 50WG addresses this need.
  4. 4. The major objective for Sumitomo Chemical was to develop a new IRS product that would not be resisted by mosquitoes which have developed resistance to one or all of the major classes of insecticides currently available for IRS. Key features & Benefits 1. New active ingredient in IRS and Public Health applications. 2. 6- 9 months duration of activity under field conditions. 3. New mode of Action – A breakthrough for resistance management programmes. 4. Non-repellent formulation, increasing exposure of mosquito to the active ingredient (unlike pyrethroids and DDT). 5. Submitted to WHO Pesticide Evaluation Scheme (WHOPES) to obtain recommendation. 6. Mortality rates which increase over time post exposure. 7. Low Toxicity. 8. Odourless. 9. Readily dilutes in water. 10. Small easy to handle sachets. 11. Easy to transport — one sachet per tank and up to 50 sachets per carton. Product Concept
  5. 5. SumiShield 50WG is odourless, has low toxicity, readily dilutes in water, and is easy to transport. New mode of action makes it a breakthrough for resistance management programmes.
  6. 6. SumiShield 50WG has been developed for IRS application - to be sprayed to the inside of houses, walls and other substrates where vectors rest Mixing instructions •  Fill sprayer with required volume of water. •  Tear open end of sachet and put entire contents directly into spray tank. •  Close sprayer, pressurize and mix by inverting spray tank before spraying. Application rates and method •  SumiShield target dose 300 mg ai/m2. •  Mix contents of 150g SumiShield 50WG sachet in 10 liters of water. •  Apply to 250m area. •  Apply with a pressure sprayer that has a WHOPES specification. •  An area of 19m should be covered in one minute. •  Pressure sprayers to be set at 4 bar. Directions for Use (1) 2 2
  7. 7. Handling Use only in well ventilated areas. Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco or using the toilet. Storage Recommendations •  Keep out of reach of children. •  Keep away from food, drink and animal feeding stuffs. •  Store only in original sachets in a safe place at temperatures not exceeding 35C. •  Diluted insecticide should never be kept; a fresh dilution should be prepared as necessary. Directions for Use (2)
  8. 8. Technical specifications Active Ingredient: Clothianidin 50.0% (w/w) Other Ingredients: 50.0% Total 100.0% Nitroguanidine (neonicotinoid) IRAC MoA Group 4A Neonicotinoids IUPAC: (E)-N-[(2-chloro-1,3-thiazol-5-yl)methyl]-N-methyl-N-nitroguanidine Formula: C6H8ClN5O2S
  9. 9. 1. Wall Bioassay Results Experimental huts were used for the trials and SumiShield 50WG was applied with a compression sprayer according to standard WHO protocol. Laboratory bred mosquitoes from 3 different An. gambiae s.s. strains were used and exposed for 30 minutes using cone bioassays according to WHO protocol. The Kisumu strain is fully susceptible while the other two strains are resistant to insecticides. SumiShield 50WG has a prolonged mortality effect and therefore mortality readings were taken up to 168 hours (7 days). Biological Efficacy (1) Experimental Hut Trials with SumiShield 50WG Figure 1 Residual efficacy of SumiShield 50WG on hut walls – 30 min exposure. Dose 300 mg ai/m2 – An. gambiae – Kismu strain %Mortality 168 hr 120 hr 72 hr 48 hr 24 hr 100 80 60 40 20 0 0 1 2 3 4 5 6 7 Months Figure 2 Residual efficacy of SumiShield 50WG on hut walls – 30 min exposure. Dose 300 mg ai/m2 – An. gambiae – KdrKis strain %Mortality 168 hr 120 hr 72 hr 48 hr 24 hr 100 80 60 40 20 0 0 1 2 3 4 5 6 7 Months
  10. 10. Biological Efficacy (2) Comment It can be seen in Figure 1 (see previous slide) that kill against susceptible Kisumu strain of mosquitoes was good. Kill was maintained against the two resistant strains shown in Figures 2 & 3 (see previous slide and at right) although there was a slight reduction in speed of action against these resistant mosquitoes. 100% kill was achieved in all cases and was still continuing at 7 months post-spray. Trials continue and it is expected that data will continue to show good levels of residual efficacy beyond 7 months. Note: Data corrected for control mortality. These experimental hut trials in Benin, West Africa were conducted by Insitut Recherche pour le développement (IRD) – C.R.E.C. Cotonou. Figure 3 Residual efficacy of SumiShield 50WG on hut walls – 30 min exposure. Dose 300 mg ai/m2 – An. gambiae – Acerkis strain %Mortality 168 hr 120 hr 72 hr 48 hr 24 hr 100 80 60 40 20 0 0 1 2 3 4 5 6 7 Months (note: no mosquitoes for months 5 & 6)
  11. 11. 2. Wild Mosquitoes Entering Experimental Huts Comment The local wild mosquitoes are naturally resistant to most insecticides especially pyrethroids and carbamates. The results in Figure 4 (next slide) reflect this resistance and while the organophosphate pirimiphos-methyl is still giving reasonable results SumiShield 50WG achieved the best results over time, noting that delayed mortality has to be assessed to determine the true efficacy of SumiShield 50WG. Excito repellency Results presented on Figure 5 (next slide) show that mosquito resting behavior on clothianidin treated surfaces is not significantly different from controls. Excito repellancy is one of the factors behind the development of resistance. High levels of excito repellancy were observed with the pyrethroid insecticides tested (deltamethrin and permethrin). Biological Efficacy (3)
  12. 12. Biological Efficacy (4) Resistance to at least one insecticide has been identified in 64 countries with on-going malaria transmission. Figure 4 Experimental hut trials – Mortality of An. gambiae wild strain – 207 nights of collection %Mortality 80 60 40 20 0 SumiShield 50WG– 300mg Pirimiphos-methyl – 1000mg Deltamethrin – 25mg Bendiocarb – 400mg 24hr 48hr 72hr 120hr 168hr Hours after capture Note: Data corrected for control mortality Figure 5 Irritant properties of insecticides against An. gambiae Kisumu strain by WHO cone test Untreated paper 10 8 6 4 2 0 1.8b 3.0b 7.4a 2.9b 3.2b 2.7b 7.3a Number of take-offs 100 80 60 40 20 0 22.9b 27.2b 74.2a 29.7b 22.1b 44.9b 86.0a Flying time (sec) in 3 min. SumiShield 50WG 200mg Ai/m2 Delta- methrin WG 25 mg Al/m2 Bendiocarb WP 400 mg Ai/m2 Pirimiphos- methyl CS 1000mg Ai/m2 Permethrin 0.75% paper Fenitro- thion WP 2000 mg Ai / m2
  13. 13. According to the EPA, clothianidin is practically non-toxic to selected test bird species that were fed relatively large doses of the chemical.
  14. 14. Acute oral LD50: LD50 is 3900mg/kg body weight (bw) for males and 4700mg/kg bw for females. Skin and eye: Very slight (barely perceptible) transient skin irritation and is an eye irritant. Inhalation LC50 (4h): for male and female rats >2.3mg/L Other: Not mutagenic. Not oncogenic in rats and mice. Not teratogenic in rats and rabbits. Reference: Pesticide Manual note 13th edition Clothianidin is moderately toxic through oral exposure, but toxicity is low through skin contact or inhalation. Since contact of householders will be via treated walls the product should not cause any significant risk. While Clothianidin may cause slight eye irritation, it is not a skin sensitizer or irritant. Clothianidin does not damage genetic material nor is there evidence that it causes cancer in rats or mice; it is unlikely to be a human carcinogen. Aquatic life United States EPA assessment report (2003) states that clothianidin should not present a direct acute or chronic risk to freshwater and estuarine/marine fish, or a risk to terrestrial or aquatic vascular and nonvascular plants. Consistent with the majority of pesticide products clothianidin is considered to be toxic to aquatic invertebrates if disposal of wastes according to disposal instructions are not followed. Birds According to the EPA, clothianidin is practically non-toxic to selected test bird species that were fed relatively large doses of the chemical on an acute basis. Mammalian Toxicity
  15. 15. www.sumivector.com © 2015 Sumitomo Chemical Company Ltd. SumiShield® is a registered trademark of Sumitomo Chemical Company Limited.

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