Biotic Games                Interactive micro-biology for                          Research,                         Educa...
Engineering and games                                          ?                                                          ...
Questions    1.  Can we bioengineer games?    2.  What are these games like?    3.  What are these games good for?        ...
Games                                                                 4STANFORD BIOENGINEERING   Riedel-Kruse Lab ingmar@s...
What are games?                    •  “structured play”                    •  goals                    •  rules           ...
Utility of games    •  (“Just”) Entertainment    •  Engaging / addictive -> coupling to secondary purpose    (“serious gam...
Bioengineering                                                                 7STANFORD BIOENGINEERING   Riedel-Kruse Lab...
What is bioengineering?    •  Biology as an engineering substrate    •  Fusion of engineering and the life sciences    •  ...
Future Stanford bioengineering building
Stanford bioengineering Human Biomechanics                                                Optogenetics Scott Delp         ...
Electrical vs. biological engineering    Transistor         Electronic circuit      “Tennis for two”   Table Tennis       ...
Bioengineered games                                                                 12STANFORD BIOENGINEERING   Riedel-Kru...
Bioengineered games (i)  Human interaction with biological material or processes (ii)  Enabled by modern biotechnology    ...
“Biotic games” (i)  Human interaction with biological material or processes (ii)  Enabled by modern biotechnology         ...
Paramecia and random walks                                                        3    2                                  ...
Action games with paramecia                                                                 16STANFORD BIOENGINEERING   Ri...
Biotic game set-up                                                      Biotic processor  Fluid chamber       Game control...
Pinball                                                                 18STANFORD BIOENGINEERING   Riedel-Kruse Lab ingma...
Pinball vs. “Biotic Pinball”                                                  1 mm / real time                            ...
First publication on biotic games                                                                 20STANFORD BIOENGINEERIN...
Comments on the web  • useless.invention.ever  • Incredible!  • Are paramecia hurt? Unethical to play with life!  • It is ...
Utility of future biotic games           1.    Education           2.    Large scale citizen science           3.    Techn...
Biotic games in education                                                                 23STANFORD BIOENGINEERING   Ried...
First test with children in museum    Daniel Schwartz    Prof. School of Education, Stanford       Computer games for     ...
First children test in museum           •  ~40 children ~10 years old           •  enjoyed direct visual through scope    ...
Games for research                                                                 26STANFORD BIOENGINEERING   Riedel-Krus...
Biotic games for large scale science      (citizen science / crowdsourcing / human computation)      Biomedical Experiment...
Citizen science game: Beans                                 How many beans are in the jar?                                ...
Biotic games for large scale science                                        Rhiju Das                        Adrien Trieul...
RNA and foldingG U G G G A         A A    A A       A C C C A C  Folding                                     Sequence  pro...
 	  	  	  	  	  	  	  	  	  	  	  	  	  	  Eterna	  :	  Demonstra-on	                                              http://...
 	  	  	  	  	  	  	  	  	  	  	  	  	  	  More	  complex	  puzzles	  
 	  	  	  	  	  	  	  	  	  	  	  	  	  	  	  	  	  	  	  	  	  	  	  	  	  EteRNA	                                       ...
EteRNA scoreTime
EteRNA score
EteRNA score
EteRNA score
EteRNA score
HumanEteRNA score               Computer
Games as technological driver                                                                 40STANFORD BIOENGINEERING   ...
Games as technological driver            (development of new technology and/or cost reductions) 3D video game graphics   G...
Games as technological driver            (development of new technology and/or cost reductions)                           ...
Games as technological driver           (development of new technology and/or cost reductions)      3rd world mobile phone...
Outlook                                                                 44STANFORD BIOENGINEERING   Riedel-Kruse Lab ingma...
Electrical vs. biological engineering    Transistor         Electronic circuit        “Tennis for two”   Table Tennis     ...
Stanford Bio.X games initiative!            (Founded ~Spring 2010; Bio-X IIP seed-funding ~Fall 2010)!                    ...
Summary Biotic Games                               •     Human player interacting with                                    ...
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Biotic Games: Interactive Microbiology - Ingmar Riedel-Kruse, Stanford Engineering

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Stanford Engineering Professor Ingmar Riedel-Kruse describes how he's creating biotic games in which humans play with real biological processes at microscopic scale. The goal is to enable crowd-sourcing of the scientific method to yield real-world advances in biotechnology.

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Biotic Games: Interactive Microbiology - Ingmar Riedel-Kruse, Stanford Engineering

  1. 1. Biotic Games Interactive micro-biology for Research, Education, and Entertainment Ingmar Riedel-KruseSTANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  2. 2. Engineering and games ? 2STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  3. 3. Questions 1.  Can we bioengineer games? 2.  What are these games like? 3.  What are these games good for? 3STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  4. 4. Games 4STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  5. 5. What are games? •  “structured play” •  goals •  rules •  challenges •  interaction 5STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  6. 6. Utility of games •  (“Just”) Entertainment •  Engaging / addictive -> coupling to secondary purpose (“serious games” – C. Abt. 1970) Fitness Education Rehabilitation Activism New technology …??? 6STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  7. 7. Bioengineering 7STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  8. 8. What is bioengineering? •  Biology as an engineering substrate •  Fusion of engineering and the life sciences •  Technology invention •  Scientific discovery •  Applications in medicine, food, energy, environment … 8STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  9. 9. Future Stanford bioengineering building
  10. 10. Stanford bioengineering Human Biomechanics Optogenetics Scott Delp RNA logic gates Christina Smolke Karl Deisseroth Micro-fluidics – Steve Quake; Bubble logic - Manu Prakash ~500 um 10STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  11. 11. Electrical vs. biological engineering Transistor Electronic circuit “Tennis for two” Table Tennis 1958 2006; Xbox 360 1947 ~1950’s Micro-fluidic valve Micro-fluidic circuit ? ~2000 ~2002 11STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  12. 12. Bioengineered games 12STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  13. 13. Bioengineered games (i)  Human interaction with biological material or processes (ii)  Enabled by modern biotechnology 13STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  14. 14. “Biotic games” (i)  Human interaction with biological material or processes (ii)  Enabled by modern biotechnology 14STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  15. 15. Paramecia and random walks 3 2 4 1 9 50 um 8 5 0.5 mm 7 6 0.5 sec 15STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  16. 16. Action games with paramecia 16STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  17. 17. Biotic game set-up Biotic processor Fluid chamber Game controller 17STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  18. 18. Pinball 18STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  19. 19. Pinball vs. “Biotic Pinball” 1 mm / real time 19STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  20. 20. First publication on biotic games 20STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  21. 21. Comments on the web • useless.invention.ever • Incredible! • Are paramecia hurt? Unethical to play with life! • It is more benign than picking a flower • Cure cancer first! • If they had Playstation in WW2, that is what the controller probably would look like. • I really like Stanford having such multidisciplinary research opportunities. 21STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  22. 22. Utility of future biotic games 1.  Education 2.  Large scale citizen science 3.  Technology driver 4.  … 22STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  23. 23. Biotic games in education 23STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  24. 24. First test with children in museum Daniel Schwartz Prof. School of Education, Stanford Computer games for education 24STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  25. 25. First children test in museum •  ~40 children ~10 years old •  enjoyed direct visual through scope •  biotic game was too difficult to play •  hardly realized that they played with real paramecia •  no ethical concerns raised -> different perceptions by age -> implications for improved design 25STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  26. 26. Games for research 26STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  27. 27. Biotic games for large scale science (citizen science / crowdsourcing / human computation) Biomedical Experiments Operated by Online Gaming Community 27STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  28. 28. Citizen science game: Beans How many beans are in the jar? Rules: •  Don’t talk •  Write down your guess •  Write down your name (other ID) •  Best guess wins •  Exchange guess with a stranger •  Let’s vote! 28STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  29. 29. Biotic games for large scale science Rhiju Das Adrien Trieulle Assist. Prof. Computer Science / Assist. Prof. Biochemistry, Stanford Robotics; Carnegie Mellon RNA folding ~10.000 players Computer graphics Experimental feedback Once per week for 8 players 29STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  30. 30. RNA and foldingG U G G G A A A A A A C C C A C Folding Sequence problem problem A A C A C C C A G U G G G A A A
  31. 31.                              Eterna  :  Demonstra-on   http://eterna.cmu.edu/game.php?myType=PUZZLE&myVal=13399
  32. 32.                              More  complex  puzzles  
  33. 33.                                                    EteRNA   Game   Verifica-on   Experiment  Loop  of  global  scale  game  playing  and  experimental  trial  &  error  
  34. 34. EteRNA scoreTime
  35. 35. EteRNA score
  36. 36. EteRNA score
  37. 37. EteRNA score
  38. 38. EteRNA score
  39. 39. HumanEteRNA score Computer
  40. 40. Games as technological driver 40STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  41. 41. Games as technological driver (development of new technology and/or cost reductions) 3D video game graphics Graphics Processing Unit (GPU) Molecular dynamic simulations Jen-Hsun Huang "Jen-Hsun Huang School of (EE MS ’92 Stanford) Engineering Center." 41STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  42. 42. Games as technological driver (development of new technology and/or cost reductions) Without video games 3D video game graphics Graphics Processing Unit (GPU) Molecular dynamic simulations No deans office Jen-Hsun Huang "Jen-Hsun Huang School of (EE MS ’92 Stanford) Engineering Center." 42STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  43. 43. Games as technological driver (development of new technology and/or cost reductions) 3rd world mobile phone Integrating micro-fluidic based diagnostics chips into phones? Hongying Zhu et al. LOC 2010 Could biotic games lower costs for mobile diagnostics? 43STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  44. 44. Outlook 44STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  45. 45. Electrical vs. biological engineering Transistor Electronic circuit “Tennis for two” Table Tennis 1958 2006; Xbox 360 1947 ~1950’s ??? Micro-fluidic valve Micro-fluidic circuit Biotic games ~2000 ~2002 ~2010 45STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
  46. 46. Stanford Bio.X games initiative! (Founded ~Spring 2010; Bio-X IIP seed-funding ~Fall 2010)! Biotic Games Educational video gamesRhiju Das Ingmar Riedel-Kruse Daniel Schwartz(Asst Prof Biochemistry, Physics) (Asst Prof Bioengineering) (Prof Education) Objectives: 1.  Develop and build biotic games 2.  Use biotic games to solve educational and scientific challenges 3.  Nucleate a world-wide biotic games community
  47. 47. Summary Biotic Games •  Human player interacting with real biology (experiments) •  Novel features •  Educational value •  Citizen science •  Technology driver •  … •  Stanford Bio.X games center 47STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu

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