The collection and use of Big Data has become an important part of modern business practice. The Internet of Things (IoT) movement promises to provide new opportunities for businesses interested in the intersection of people and technology. It is also wrought with pitfalls for practitioners and researchers who struggle to make sense of an increasing cacophony of signals. How should they poll and collect data from millions of signals in a way that is manageable, scalable, and statistically valid? How should they analyze and predict using these data? This presentation will discuss these challenges with applied examples from monitoring and managing one of the world’s largest computers.