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Food Drug Interaction 1 copy.pptx

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Food Drug Interaction 1 copy.pptx

  1. 1. Food Drug Interaction The presentator Pharmasict Mohammed malk jassim
  2. 2. Learning Objectives : Know what a food-drug interaction Know common foods and drugs interactions Know the effect of the interaction on the body Know how to help avoid food-drug interactions
  3. 3. Introduction: A food-drug interaction is a situation when active chemicals in drug reacts to a nutrient or food item and causes the drug to be  Less effective than expected  More effective than expected  May cause an effect in the body that could be extremely harmful to the person.
  4. 4. Why are food-drug interaction important ?  Impact how effective a drug is, or its efficacy  Increased metabolism can cause less of the drug effective  decreased metabolism can cause high levels of drug in the body which can be toxic and cause unwanted side effects
  5. 5. Introduction: Food is either restricted or provided at a time before or after the medication has been given to prevent any food-drug interactions.
  6. 6. common foods and drugs interactions: Grapefruit
  7. 7. Grapefruit The grapefruit is a subtropical citrus tree known for its relatively large, sour to semi-sweet, somewhat bitter fruit. The interior flesh is segmented and varies in color from pale yellow to dark pink.
  8. 8. Grapefruit Grapefruit and grapefruit juice have been found to interact with numerous drugs and in many cases, to result in adverse direct and/or side effects (if dosage is not carefully adjusted). inhibit the CYP3A4 enzyme, including the P450 enzyme family responsible for metabolizing 90% of drugs.
  9. 9. Grapefruit  The effect on statins  Statins are broken down by enzymes in the liver  The Grapefruit can block the action of this enzymes which would cause more of the statins to enter the body than intended  Ex of statins drugs  Atorvastatin  Rosovastatin
  10. 10. Grapefruit  The effect on calcium channel blocker  Calcium channel blockers are medicines that relax the muscles that make up the walls of your arteries.  They're used as part of the treatment of conditions such as high blood pressure and coronary heart diseases  Grapefruit juice interacts with some calcium channel blockers and increases the level of the medicine in your blood.
  11. 11. Grapefruit  Potential side effects  Muscle damage  Liver dame  Digestive problems  Neurological side effects
  12. 12. Licorice
  13. 13. Licorice  Licorice is extracted from the roots of the tree, which is sweeter than sugar, and extracted from the roots of the tree, as a sweetener.  In the year (1955-1960) a citroid compound was separated and called glycerrhysic acid from the roots of the licorice plant. It was found that this acid is similar in its chemical structure to cortisone.
  14. 14. Licorice  Noting that continuing to use it for a long time or increasing the dose has negative effects such as headache, high blood pressure, fluid retention and potassium deficiency.
  15. 15. Licorice  The effect of licorice on the HT drugs  Common interaction with ACEi, ARBs,CCB,Diurretics.  It decrease the HT drugs effect by block the activity of 11hydroxysteroid-dehydrogenase causing salt and water retention than increase in HT
  16. 16. Licorice  The effect of licorice on the HEART drugs  The intake of Licorice with Digoxin can cause irregular heartbeat and heart attack.  It can decease the level of potassium
  17. 17. Syzygium cumini
  18. 18. Syzygium cumini  Syzygium Cumini (Jamun): Jamun fruit also called as sIndian blackberry. Syzygium cumini at a dose level of 50 mg/kg also showed significant decrease in blood glucose level.
  19. 19. Syzygium cumini  Jamun traditionally used as anti-diabetic agent; so that it should be avoided and contraindicated during the treatment of diabetes because the administration of oral hypoglycemic agents along with Jamun may leads to severe hypoglycemia
  20. 20. Momordica Charantia
  21. 21. Momordica Charantia  Momordica Charantia (Karela): Bitter Melon : is a Tropical vegetable and common food in Indian cuisine and has been used extensively in folk medicine as a remedy for diabetes. It has also been shown to have hypoglycaemic properties in the animal as well as effective in humans. It has been reported that intake increases the number of beta cells in the pancreas thereby improving the body’s ability to produce insulin..
  22. 22. Momordica Charantia  The fruit has also shown the ability to promote insulin release by enhancing cells uptake of glucose and potentiate the effect of insulin.
  23. 23. Momordica Charantia  Extremely high doses of the juice of Karela (bitter melon) can cause diarrhoea and abdominal pain. Bitter melon should not be used and avoided for small children or anyone with hypoglycemia, as it may trigger or worsen low blood glucose or hypoglycemia..
  24. 24. Momordica Charantia  The use of KARELA should be avoided in pregnant women as it stimulates the uterus and may cause premature birth
  25. 25. Garlic
  26. 26. Garlic  Garlic has been widely used for reducing the high cholesterol. Garlic has also been used for treating or myriad other disorders (such as atherosclerosis, diabetes, fungal infections, cancer, hypertension, myocardial infarction and peripheral vascular disease)
  27. 27. Garlic  Garlic oil shown hypoglycemic effect in diabetic animals as well as in humans has also been reported. Co-administered of glimepiride with garlic resulted in tight glycaemic control due to the hypoglycemic properties of garlic as well as glimepiride
  28. 28. how to help avoid food-drug interactions  Counsel patients to  Read drug labels  Learn about the warning for the drug they take  Check with doctor or pharmacist before taking an OTC drug if they are taking any prescription medications  Inform all healthcare professionals about all medications and supplements they are taking
  29. 29.  Drug Interactions Checker - For Drugs, Food & Alcohol

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