A long-standing grand challenge in computing is to enable machines to act autonomously and intelligently: to rapidly and repeatedly take appropriate actions based on information in the world around them. To address this challenge, at UC Berkeley we are starting a new five year effort that focuses on the development of data-intensive systems that provide Real-Time Intelligence with Secure Execution (RISE). Following in the footsteps of AMPLab, RISELab is an interdisciplinary effort bringing together researchers across AI, robotics, security, and data systems. In this talk I’ll present our research vision and then discuss some of the applications that will be enabled by RISE technologies.