SlideShare a Scribd company logo
Purine Degradation
Steps involved in purine Degradation
• The end product of purine metabolism in
humans is uric acid.
• The nucleotide monophosphates (AMP, IMP
& GMP) are converted to their respective
nucleoside forms (adenosine, inosine &
guanosine) by the action of nucleotidase.
• The amino group, either from AMP or adenosine,
can be removed to produce IMP or ionosine.
• Inosine & guanosine are converted to
hypoxanthine & guanine (purine bases) by
purine nucleoside phosphorylase.
• Adenosine is not degraded by this enzyme, it
has to be converted to inosine.
• Guanine undergoes deamination by guanase to
form xanthine.
• Xanthine oxidase converts hypoxanthine to
xanthine & xanthine to uric acid.
• This enzyme contains FAD, molybdenum &
iron.
• It is exclusively found in liver & small intestine.
Uric acid(2,6,8 trioxypurine)
• It is final excretory product of
purine metabolism in humans.
• Uric acid can serve as an
important antioxidant by
getting itself converted (non-
enzymatically) to allantoin.
• It is believed that the
antioxidant role of ascorbic
acid in primates is replaced by
uric acid.
Degradation of Uric acid other than
human beings.
• Most animals (other than
primates) oxidize uric acid by the
enzyme uricase to allantoin,
where the purine ring is cleaved.
• Allantoin is then converted to
allantoic acid & excreted in
some fishes.
• Further degradation of allantoic
acid may occur to produce urea
(in amphibians, most fishes &
some molluscs) & to ammonia
(in marine invertebrates).
Purine degradation

More Related Content

What's hot

Purine and Pyrimidine biosynthesis
Purine and Pyrimidine biosynthesisPurine and Pyrimidine biosynthesis
Purine and Pyrimidine biosynthesis
Sripati Abhiram Sahoo
 
BIOSYNTHESIS OF PURINE NUCLEOTIDES
BIOSYNTHESIS OF PURINE NUCLEOTIDESBIOSYNTHESIS OF PURINE NUCLEOTIDES
BIOSYNTHESIS OF PURINE NUCLEOTIDES
YESANNA
 
PURINE DEGRADATION & GOUT
PURINE DEGRADATION & GOUTPURINE DEGRADATION & GOUT
PURINE DEGRADATION & GOUT
YESANNA
 
Pyrimidine Synthesis and Degradation
Pyrimidine Synthesis and DegradationPyrimidine Synthesis and Degradation
Pyrimidine Synthesis and Degradation
Ashok Katta
 
Pyrimidine metabolism
Pyrimidine metabolismPyrimidine metabolism
Pyrimidine metabolism
biochemistry1234
 
Bpt 114. purine and pyrimidine metabolism
Bpt 114. purine and pyrimidine metabolismBpt 114. purine and pyrimidine metabolism
Bpt 114. purine and pyrimidine metabolism
Dr. Geoffrey K. K. Maiyoh
 
Disorders of pyrimidine metabolism
Disorders of pyrimidine metabolismDisorders of pyrimidine metabolism
Disorders of pyrimidine metabolism
Dr. Geoffrey K. K. Maiyoh
 
Biosynthesis of purine
Biosynthesis of purineBiosynthesis of purine
Biosynthesis of purine
KARTHIK REDDY C A
 
Amino acid metabolism
Amino acid metabolismAmino acid metabolism
Amino acid metabolism
Oheneba Hagan
 
Nucleotide metabolism
Nucleotide metabolismNucleotide metabolism
Nucleotide metabolism
Dipesh Tamrakar
 
Purine & pyrimidine metabolism and disorders
Purine & pyrimidine metabolism and disordersPurine & pyrimidine metabolism and disorders
Purine & pyrimidine metabolism and disorders
International Medicine School - Management and Science University
 
Nucleic acid introduction & metabolism
Nucleic acid introduction & metabolismNucleic acid introduction & metabolism
Nucleic acid introduction & metabolism
kirankumarsolanki3
 
GLYCOGENESIS
GLYCOGENESISGLYCOGENESIS
GLYCOGENESIS
YESANNA
 
URONIC ACID PATHWAY
URONIC ACID PATHWAYURONIC ACID PATHWAY
URONIC ACID PATHWAY
YESANNA
 
Nucleotide metabolism (purine and pyrimidine synthesis)
Nucleotide metabolism (purine and pyrimidine synthesis)Nucleotide metabolism (purine and pyrimidine synthesis)
Nucleotide metabolism (purine and pyrimidine synthesis)
Areeba Ghayas
 
PYRIMIDINE SYNTHESIS
PYRIMIDINE SYNTHESISPYRIMIDINE SYNTHESIS
PYRIMIDINE SYNTHESIS
YESANNA
 
Amino acid metabolism
Amino acid metabolismAmino acid metabolism
Amino acid metabolism
Dipali Kulkarni
 
Metabolism of amino acids
Metabolism of amino acids Metabolism of amino acids
Metabolism of amino acids
Arun Geetha Viswanathan
 
Biosynthesis of nucleotides
Biosynthesis of nucleotidesBiosynthesis of nucleotides
Biosynthesis of nucleotides
Prachee Rajput
 
BIOSYNTHESIS OF NUCLEOTIDE COENZYMES AND THEIR ROLE IN METABOLISM
BIOSYNTHESIS OF NUCLEOTIDE COENZYMES AND THEIR ROLE IN METABOLISMBIOSYNTHESIS OF NUCLEOTIDE COENZYMES AND THEIR ROLE IN METABOLISM
BIOSYNTHESIS OF NUCLEOTIDE COENZYMES AND THEIR ROLE IN METABOLISM
Naba Kalita
 

What's hot (20)

Purine and Pyrimidine biosynthesis
Purine and Pyrimidine biosynthesisPurine and Pyrimidine biosynthesis
Purine and Pyrimidine biosynthesis
 
BIOSYNTHESIS OF PURINE NUCLEOTIDES
BIOSYNTHESIS OF PURINE NUCLEOTIDESBIOSYNTHESIS OF PURINE NUCLEOTIDES
BIOSYNTHESIS OF PURINE NUCLEOTIDES
 
PURINE DEGRADATION & GOUT
PURINE DEGRADATION & GOUTPURINE DEGRADATION & GOUT
PURINE DEGRADATION & GOUT
 
Pyrimidine Synthesis and Degradation
Pyrimidine Synthesis and DegradationPyrimidine Synthesis and Degradation
Pyrimidine Synthesis and Degradation
 
Pyrimidine metabolism
Pyrimidine metabolismPyrimidine metabolism
Pyrimidine metabolism
 
Bpt 114. purine and pyrimidine metabolism
Bpt 114. purine and pyrimidine metabolismBpt 114. purine and pyrimidine metabolism
Bpt 114. purine and pyrimidine metabolism
 
Disorders of pyrimidine metabolism
Disorders of pyrimidine metabolismDisorders of pyrimidine metabolism
Disorders of pyrimidine metabolism
 
Biosynthesis of purine
Biosynthesis of purineBiosynthesis of purine
Biosynthesis of purine
 
Amino acid metabolism
Amino acid metabolismAmino acid metabolism
Amino acid metabolism
 
Nucleotide metabolism
Nucleotide metabolismNucleotide metabolism
Nucleotide metabolism
 
Purine & pyrimidine metabolism and disorders
Purine & pyrimidine metabolism and disordersPurine & pyrimidine metabolism and disorders
Purine & pyrimidine metabolism and disorders
 
Nucleic acid introduction & metabolism
Nucleic acid introduction & metabolismNucleic acid introduction & metabolism
Nucleic acid introduction & metabolism
 
GLYCOGENESIS
GLYCOGENESISGLYCOGENESIS
GLYCOGENESIS
 
URONIC ACID PATHWAY
URONIC ACID PATHWAYURONIC ACID PATHWAY
URONIC ACID PATHWAY
 
Nucleotide metabolism (purine and pyrimidine synthesis)
Nucleotide metabolism (purine and pyrimidine synthesis)Nucleotide metabolism (purine and pyrimidine synthesis)
Nucleotide metabolism (purine and pyrimidine synthesis)
 
PYRIMIDINE SYNTHESIS
PYRIMIDINE SYNTHESISPYRIMIDINE SYNTHESIS
PYRIMIDINE SYNTHESIS
 
Amino acid metabolism
Amino acid metabolismAmino acid metabolism
Amino acid metabolism
 
Metabolism of amino acids
Metabolism of amino acids Metabolism of amino acids
Metabolism of amino acids
 
Biosynthesis of nucleotides
Biosynthesis of nucleotidesBiosynthesis of nucleotides
Biosynthesis of nucleotides
 
BIOSYNTHESIS OF NUCLEOTIDE COENZYMES AND THEIR ROLE IN METABOLISM
BIOSYNTHESIS OF NUCLEOTIDE COENZYMES AND THEIR ROLE IN METABOLISMBIOSYNTHESIS OF NUCLEOTIDE COENZYMES AND THEIR ROLE IN METABOLISM
BIOSYNTHESIS OF NUCLEOTIDE COENZYMES AND THEIR ROLE IN METABOLISM
 

Similar to Purine degradation

Degradation of purine[1]
Degradation of purine[1]Degradation of purine[1]
Degradation of purine[1]
Rajnish Madhukar
 
Purine nuecleotide
Purine nuecleotidePurine nuecleotide
Purine nuecleotide
BakhtawarFarooq
 
Metabolism of nucleotides new
Metabolism of nucleotides newMetabolism of nucleotides new
Metabolism of nucleotides new
Dr.M.Prasad Naidu
 
Nucleic acid & Nucelotides
Nucleic acid & NucelotidesNucleic acid & Nucelotides
Nucleic acid & Nucelotides
Pratishtha sharma
 
Lec 3 level 3-de(protein metabolism &urea cycle)
Lec 3  level 3-de(protein metabolism &urea cycle)Lec 3  level 3-de(protein metabolism &urea cycle)
Lec 3 level 3-de(protein metabolism &urea cycle)
dream10f
 
Handouts molecular biology-1
Handouts  molecular biology-1Handouts  molecular biology-1
Handouts molecular biology-1
Ministry of Education, Ethiopia
 
Nucleotide chemistry & metabolism
Nucleotide chemistry & metabolismNucleotide chemistry & metabolism
Nucleotide chemistry & metabolism
sarojben
 
Metabolism protein
Metabolism proteinMetabolism protein
Metabolism protein
Prakash Pokhrel
 
Metabolism of Protein and Amino Acids
Metabolism of Protein and Amino AcidsMetabolism of Protein and Amino Acids
Metabolism of Protein and Amino Acids
Farhana Atia
 
TOBIAS BIOSYNTHESIS OF AMINO ACIDS PRESENTATION.pptx
TOBIAS BIOSYNTHESIS OF AMINO ACIDS PRESENTATION.pptxTOBIAS BIOSYNTHESIS OF AMINO ACIDS PRESENTATION.pptx
TOBIAS BIOSYNTHESIS OF AMINO ACIDS PRESENTATION.pptx
elphaswalela
 
Nucleotide Metabolism mbbs part I 23-24.pptx
Nucleotide Metabolism mbbs part  I 23-24.pptxNucleotide Metabolism mbbs part  I 23-24.pptx
Nucleotide Metabolism mbbs part I 23-24.pptx
AnandVeeranan
 
metab. of nucleotide 1.pptx
metab. of nucleotide 1.pptxmetab. of nucleotide 1.pptx
metab. of nucleotide 1.pptx
jaswant kaur
 
Urea
UreaUrea
Uncommon amino acid by KK Sahu sir
Uncommon amino acid by KK Sahu sirUncommon amino acid by KK Sahu sir
Uncommon amino acid by KK Sahu sir
KAUSHAL SAHU
 
urea cycle.pptx
urea cycle.pptxurea cycle.pptx
urea cycle.pptx
AmitSamadhiya1
 
Lec3 level3-nunitrogenmetabolism-130204053253-phpapp01
Lec3 level3-nunitrogenmetabolism-130204053253-phpapp01Lec3 level3-nunitrogenmetabolism-130204053253-phpapp01
Lec3 level3-nunitrogenmetabolism-130204053253-phpapp01
Cleophas Rwemera
 
Digestion of proteins (1).ppt
Digestion of proteins (1).pptDigestion of proteins (1).ppt
Digestion of proteins (1).ppt
Kiran Kumar
 
Lec3 level3-deproteinmetabolismureacycle-130202042721-phpapp02
Lec3 level3-deproteinmetabolismureacycle-130202042721-phpapp02Lec3 level3-deproteinmetabolismureacycle-130202042721-phpapp02
Lec3 level3-deproteinmetabolismureacycle-130202042721-phpapp02
Cleophas Rwemera
 
Lecture 3. Metabolism of purines & pyrimidines 20 Aug 21.ppt
Lecture 3. Metabolism of purines & pyrimidines 20 Aug 21.pptLecture 3. Metabolism of purines & pyrimidines 20 Aug 21.ppt
Lecture 3. Metabolism of purines & pyrimidines 20 Aug 21.ppt
Dr Vishnu Kumar
 
Amino acids & proteins
Amino acids & proteinsAmino acids & proteins
Amino acids & proteins
mbalbaa
 

Similar to Purine degradation (20)

Degradation of purine[1]
Degradation of purine[1]Degradation of purine[1]
Degradation of purine[1]
 
Purine nuecleotide
Purine nuecleotidePurine nuecleotide
Purine nuecleotide
 
Metabolism of nucleotides new
Metabolism of nucleotides newMetabolism of nucleotides new
Metabolism of nucleotides new
 
Nucleic acid & Nucelotides
Nucleic acid & NucelotidesNucleic acid & Nucelotides
Nucleic acid & Nucelotides
 
Lec 3 level 3-de(protein metabolism &urea cycle)
Lec 3  level 3-de(protein metabolism &urea cycle)Lec 3  level 3-de(protein metabolism &urea cycle)
Lec 3 level 3-de(protein metabolism &urea cycle)
 
Handouts molecular biology-1
Handouts  molecular biology-1Handouts  molecular biology-1
Handouts molecular biology-1
 
Nucleotide chemistry & metabolism
Nucleotide chemistry & metabolismNucleotide chemistry & metabolism
Nucleotide chemistry & metabolism
 
Metabolism protein
Metabolism proteinMetabolism protein
Metabolism protein
 
Metabolism of Protein and Amino Acids
Metabolism of Protein and Amino AcidsMetabolism of Protein and Amino Acids
Metabolism of Protein and Amino Acids
 
TOBIAS BIOSYNTHESIS OF AMINO ACIDS PRESENTATION.pptx
TOBIAS BIOSYNTHESIS OF AMINO ACIDS PRESENTATION.pptxTOBIAS BIOSYNTHESIS OF AMINO ACIDS PRESENTATION.pptx
TOBIAS BIOSYNTHESIS OF AMINO ACIDS PRESENTATION.pptx
 
Nucleotide Metabolism mbbs part I 23-24.pptx
Nucleotide Metabolism mbbs part  I 23-24.pptxNucleotide Metabolism mbbs part  I 23-24.pptx
Nucleotide Metabolism mbbs part I 23-24.pptx
 
metab. of nucleotide 1.pptx
metab. of nucleotide 1.pptxmetab. of nucleotide 1.pptx
metab. of nucleotide 1.pptx
 
Urea
UreaUrea
Urea
 
Uncommon amino acid by KK Sahu sir
Uncommon amino acid by KK Sahu sirUncommon amino acid by KK Sahu sir
Uncommon amino acid by KK Sahu sir
 
urea cycle.pptx
urea cycle.pptxurea cycle.pptx
urea cycle.pptx
 
Lec3 level3-nunitrogenmetabolism-130204053253-phpapp01
Lec3 level3-nunitrogenmetabolism-130204053253-phpapp01Lec3 level3-nunitrogenmetabolism-130204053253-phpapp01
Lec3 level3-nunitrogenmetabolism-130204053253-phpapp01
 
Digestion of proteins (1).ppt
Digestion of proteins (1).pptDigestion of proteins (1).ppt
Digestion of proteins (1).ppt
 
Lec3 level3-deproteinmetabolismureacycle-130202042721-phpapp02
Lec3 level3-deproteinmetabolismureacycle-130202042721-phpapp02Lec3 level3-deproteinmetabolismureacycle-130202042721-phpapp02
Lec3 level3-deproteinmetabolismureacycle-130202042721-phpapp02
 
Lecture 3. Metabolism of purines & pyrimidines 20 Aug 21.ppt
Lecture 3. Metabolism of purines & pyrimidines 20 Aug 21.pptLecture 3. Metabolism of purines & pyrimidines 20 Aug 21.ppt
Lecture 3. Metabolism of purines & pyrimidines 20 Aug 21.ppt
 
Amino acids & proteins
Amino acids & proteinsAmino acids & proteins
Amino acids & proteins
 

More from Government Pharmacy College Sajong, Government of Sikkim

Edible vaccines-Pharmacognosy and Phytochemistry.pptx
Edible vaccines-Pharmacognosy and Phytochemistry.pptxEdible vaccines-Pharmacognosy and Phytochemistry.pptx
Edible vaccines-Pharmacognosy and Phytochemistry.pptx
Government Pharmacy College Sajong, Government of Sikkim
 
Alkaloids and its containng drugs secondary metabolities.ppt
Alkaloids and its containng drugs secondary metabolities.pptAlkaloids and its containng drugs secondary metabolities.ppt
Alkaloids and its containng drugs secondary metabolities.ppt
Government Pharmacy College Sajong, Government of Sikkim
 
SECONDARY METABOLITIES Glycosidesss .pptx
SECONDARY METABOLITIES Glycosidesss .pptxSECONDARY METABOLITIES Glycosidesss .pptx
SECONDARY METABOLITIES Glycosidesss .pptx
Government Pharmacy College Sajong, Government of Sikkim
 
SECONDARY METABOLITIES PHARMACOGNOSY.pptx
SECONDARY METABOLITIES PHARMACOGNOSY.pptxSECONDARY METABOLITIES PHARMACOGNOSY.pptx
SECONDARY METABOLITIES PHARMACOGNOSY.pptx
Government Pharmacy College Sajong, Government of Sikkim
 
Primary Metabolites PHARMACOGNOSY-I.pptx
Primary Metabolites  PHARMACOGNOSY-I.pptxPrimary Metabolites  PHARMACOGNOSY-I.pptx
Primary Metabolites PHARMACOGNOSY-I.pptx
Government Pharmacy College Sajong, Government of Sikkim
 
TANNINS CONTAINING CRUDE DRUGS CATECHU.ppt
TANNINS CONTAINING CRUDE DRUGS CATECHU.pptTANNINS CONTAINING CRUDE DRUGS CATECHU.ppt
TANNINS CONTAINING CRUDE DRUGS CATECHU.ppt
Government Pharmacy College Sajong, Government of Sikkim
 
Natural allergens FROM PLANTS AND ANIMALS.pptx
Natural allergens FROM PLANTS AND ANIMALS.pptxNatural allergens FROM PLANTS AND ANIMALS.pptx
Natural allergens FROM PLANTS AND ANIMALS.pptx
Government Pharmacy College Sajong, Government of Sikkim
 
Organised and unorganised crude drugs.ppt
Organised and unorganised crude drugs.pptOrganised and unorganised crude drugs.ppt
Organised and unorganised crude drugs.ppt
Government Pharmacy College Sajong, Government of Sikkim
 
LIPIDS CONTAINING CRUDE DRUGS FROM PLANTS AND ANIMALS.pptx
LIPIDS CONTAINING CRUDE DRUGS FROM PLANTS AND ANIMALS.pptxLIPIDS CONTAINING CRUDE DRUGS FROM PLANTS AND ANIMALS.pptx
LIPIDS CONTAINING CRUDE DRUGS FROM PLANTS AND ANIMALS.pptx
Government Pharmacy College Sajong, Government of Sikkim
 
QUALITY CONTROL OF CRUDE DRUGS EVALUATION OF CRUDE DRUGS .pptx
QUALITY CONTROL OF CRUDE DRUGS EVALUATION OF CRUDE DRUGS .pptxQUALITY CONTROL OF CRUDE DRUGS EVALUATION OF CRUDE DRUGS .pptx
QUALITY CONTROL OF CRUDE DRUGS EVALUATION OF CRUDE DRUGS .pptx
Government Pharmacy College Sajong, Government of Sikkim
 
Primary Metabolites FROM THE PLANT AND ANIMALS.pptx
Primary Metabolites FROM THE PLANT AND ANIMALS.pptxPrimary Metabolites FROM THE PLANT AND ANIMALS.pptx
Primary Metabolites FROM THE PLANT AND ANIMALS.pptx
Government Pharmacy College Sajong, Government of Sikkim
 
VOLATILE OILS CONTAINING CRUDE DRUGS.pptx
VOLATILE OILS CONTAINING CRUDE DRUGS.pptxVOLATILE OILS CONTAINING CRUDE DRUGS.pptx
VOLATILE OILS CONTAINING CRUDE DRUGS.pptx
Government Pharmacy College Sajong, Government of Sikkim
 
Fibres FROM PLANT AND ANIMAL SOURCES.pptx
Fibres FROM PLANT AND ANIMAL SOURCES.pptxFibres FROM PLANT AND ANIMAL SOURCES.pptx
Fibres FROM PLANT AND ANIMAL SOURCES.pptx
Government Pharmacy College Sajong, Government of Sikkim
 
CULTIVATION, COLLECTION, PROCESSING AND STORAGE OF CRUDE DRUGS.pptx
CULTIVATION, COLLECTION, PROCESSING AND STORAGE OF CRUDE DRUGS.pptxCULTIVATION, COLLECTION, PROCESSING AND STORAGE OF CRUDE DRUGS.pptx
CULTIVATION, COLLECTION, PROCESSING AND STORAGE OF CRUDE DRUGS.pptx
Government Pharmacy College Sajong, Government of Sikkim
 
CLASSIFICATION OF CRUDE DRUGS SLIDESSS.pptx
CLASSIFICATION OF CRUDE DRUGS SLIDESSS.pptxCLASSIFICATION OF CRUDE DRUGS SLIDESSS.pptx
CLASSIFICATION OF CRUDE DRUGS SLIDESSS.pptx
Government Pharmacy College Sajong, Government of Sikkim
 
Introduction to Pharmacognosy AND ITS SIGNIFICANCE.ppt
Introduction to Pharmacognosy AND ITS SIGNIFICANCE.pptIntroduction to Pharmacognosy AND ITS SIGNIFICANCE.ppt
Introduction to Pharmacognosy AND ITS SIGNIFICANCE.ppt
Government Pharmacy College Sajong, Government of Sikkim
 
ADULTERATION AND DETEROATATION AS PER THE PCI
ADULTERATION AND DETEROATATION AS PER THE PCIADULTERATION AND DETEROATATION AS PER THE PCI
ADULTERATION AND DETEROATATION AS PER THE PCI
Government Pharmacy College Sajong, Government of Sikkim
 
GPCS NCC CATALOGUE - Copy.pdf
GPCS NCC CATALOGUE - Copy.pdfGPCS NCC CATALOGUE - Copy.pdf
Teratogens and Hallucinogens.pptx
Teratogens and Hallucinogens.pptxTeratogens and Hallucinogens.pptx

More from Government Pharmacy College Sajong, Government of Sikkim (20)

Edible vaccines-Pharmacognosy and Phytochemistry.pptx
Edible vaccines-Pharmacognosy and Phytochemistry.pptxEdible vaccines-Pharmacognosy and Phytochemistry.pptx
Edible vaccines-Pharmacognosy and Phytochemistry.pptx
 
Alkaloids and its containng drugs secondary metabolities.ppt
Alkaloids and its containng drugs secondary metabolities.pptAlkaloids and its containng drugs secondary metabolities.ppt
Alkaloids and its containng drugs secondary metabolities.ppt
 
SECONDARY METABOLITIES Glycosidesss .pptx
SECONDARY METABOLITIES Glycosidesss .pptxSECONDARY METABOLITIES Glycosidesss .pptx
SECONDARY METABOLITIES Glycosidesss .pptx
 
SECONDARY METABOLITIES PHARMACOGNOSY.pptx
SECONDARY METABOLITIES PHARMACOGNOSY.pptxSECONDARY METABOLITIES PHARMACOGNOSY.pptx
SECONDARY METABOLITIES PHARMACOGNOSY.pptx
 
Primary Metabolites PHARMACOGNOSY-I.pptx
Primary Metabolites  PHARMACOGNOSY-I.pptxPrimary Metabolites  PHARMACOGNOSY-I.pptx
Primary Metabolites PHARMACOGNOSY-I.pptx
 
TANNINS CONTAINING CRUDE DRUGS CATECHU.ppt
TANNINS CONTAINING CRUDE DRUGS CATECHU.pptTANNINS CONTAINING CRUDE DRUGS CATECHU.ppt
TANNINS CONTAINING CRUDE DRUGS CATECHU.ppt
 
Natural allergens FROM PLANTS AND ANIMALS.pptx
Natural allergens FROM PLANTS AND ANIMALS.pptxNatural allergens FROM PLANTS AND ANIMALS.pptx
Natural allergens FROM PLANTS AND ANIMALS.pptx
 
Organised and unorganised crude drugs.ppt
Organised and unorganised crude drugs.pptOrganised and unorganised crude drugs.ppt
Organised and unorganised crude drugs.ppt
 
LIPIDS CONTAINING CRUDE DRUGS FROM PLANTS AND ANIMALS.pptx
LIPIDS CONTAINING CRUDE DRUGS FROM PLANTS AND ANIMALS.pptxLIPIDS CONTAINING CRUDE DRUGS FROM PLANTS AND ANIMALS.pptx
LIPIDS CONTAINING CRUDE DRUGS FROM PLANTS AND ANIMALS.pptx
 
QUALITY CONTROL OF CRUDE DRUGS EVALUATION OF CRUDE DRUGS .pptx
QUALITY CONTROL OF CRUDE DRUGS EVALUATION OF CRUDE DRUGS .pptxQUALITY CONTROL OF CRUDE DRUGS EVALUATION OF CRUDE DRUGS .pptx
QUALITY CONTROL OF CRUDE DRUGS EVALUATION OF CRUDE DRUGS .pptx
 
Primary Metabolites FROM THE PLANT AND ANIMALS.pptx
Primary Metabolites FROM THE PLANT AND ANIMALS.pptxPrimary Metabolites FROM THE PLANT AND ANIMALS.pptx
Primary Metabolites FROM THE PLANT AND ANIMALS.pptx
 
VOLATILE OILS CONTAINING CRUDE DRUGS.pptx
VOLATILE OILS CONTAINING CRUDE DRUGS.pptxVOLATILE OILS CONTAINING CRUDE DRUGS.pptx
VOLATILE OILS CONTAINING CRUDE DRUGS.pptx
 
Fibres FROM PLANT AND ANIMAL SOURCES.pptx
Fibres FROM PLANT AND ANIMAL SOURCES.pptxFibres FROM PLANT AND ANIMAL SOURCES.pptx
Fibres FROM PLANT AND ANIMAL SOURCES.pptx
 
CULTIVATION, COLLECTION, PROCESSING AND STORAGE OF CRUDE DRUGS.pptx
CULTIVATION, COLLECTION, PROCESSING AND STORAGE OF CRUDE DRUGS.pptxCULTIVATION, COLLECTION, PROCESSING AND STORAGE OF CRUDE DRUGS.pptx
CULTIVATION, COLLECTION, PROCESSING AND STORAGE OF CRUDE DRUGS.pptx
 
CLASSIFICATION OF CRUDE DRUGS SLIDESSS.pptx
CLASSIFICATION OF CRUDE DRUGS SLIDESSS.pptxCLASSIFICATION OF CRUDE DRUGS SLIDESSS.pptx
CLASSIFICATION OF CRUDE DRUGS SLIDESSS.pptx
 
Introduction to Pharmacognosy AND ITS SIGNIFICANCE.ppt
Introduction to Pharmacognosy AND ITS SIGNIFICANCE.pptIntroduction to Pharmacognosy AND ITS SIGNIFICANCE.ppt
Introduction to Pharmacognosy AND ITS SIGNIFICANCE.ppt
 
ADULTERATION AND DETEROATATION AS PER THE PCI
ADULTERATION AND DETEROATATION AS PER THE PCIADULTERATION AND DETEROATATION AS PER THE PCI
ADULTERATION AND DETEROATATION AS PER THE PCI
 
GPCS NCC CATALOGUE - Copy.pdf
GPCS NCC CATALOGUE - Copy.pdfGPCS NCC CATALOGUE - Copy.pdf
GPCS NCC CATALOGUE - Copy.pdf
 
SWAYAM.pptx
SWAYAM.pptxSWAYAM.pptx
SWAYAM.pptx
 
Teratogens and Hallucinogens.pptx
Teratogens and Hallucinogens.pptxTeratogens and Hallucinogens.pptx
Teratogens and Hallucinogens.pptx
 

Recently uploaded

Pengantar Penggunaan Flutter - Dart programming language1.pptx
Pengantar Penggunaan Flutter - Dart programming language1.pptxPengantar Penggunaan Flutter - Dart programming language1.pptx
Pengantar Penggunaan Flutter - Dart programming language1.pptx
Fajar Baskoro
 
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...
Dr. Vinod Kumar Kanvaria
 
RHEOLOGY Physical pharmaceutics-II notes for B.pharm 4th sem students
RHEOLOGY Physical pharmaceutics-II notes for B.pharm 4th sem studentsRHEOLOGY Physical pharmaceutics-II notes for B.pharm 4th sem students
RHEOLOGY Physical pharmaceutics-II notes for B.pharm 4th sem students
Himanshu Rai
 
Your Skill Boost Masterclass: Strategies for Effective Upskilling
Your Skill Boost Masterclass: Strategies for Effective UpskillingYour Skill Boost Masterclass: Strategies for Effective Upskilling
Your Skill Boost Masterclass: Strategies for Effective Upskilling
Excellence Foundation for South Sudan
 
Pollock and Snow "DEIA in the Scholarly Landscape, Session One: Setting Expec...
Pollock and Snow "DEIA in the Scholarly Landscape, Session One: Setting Expec...Pollock and Snow "DEIA in the Scholarly Landscape, Session One: Setting Expec...
Pollock and Snow "DEIA in the Scholarly Landscape, Session One: Setting Expec...
National Information Standards Organization (NISO)
 
Chapter wise All Notes of First year Basic Civil Engineering.pptx
Chapter wise All Notes of First year Basic Civil Engineering.pptxChapter wise All Notes of First year Basic Civil Engineering.pptx
Chapter wise All Notes of First year Basic Civil Engineering.pptx
Denish Jangid
 
The basics of sentences session 6pptx.pptx
The basics of sentences session 6pptx.pptxThe basics of sentences session 6pptx.pptx
The basics of sentences session 6pptx.pptx
heathfieldcps1
 
How to Create a More Engaging and Human Online Learning Experience
How to Create a More Engaging and Human Online Learning Experience How to Create a More Engaging and Human Online Learning Experience
How to Create a More Engaging and Human Online Learning Experience
Wahiba Chair Training & Consulting
 
How to deliver Powerpoint Presentations.pptx
How to deliver Powerpoint  Presentations.pptxHow to deliver Powerpoint  Presentations.pptx
How to deliver Powerpoint Presentations.pptx
HajraNaeem15
 
Liberal Approach to the Study of Indian Politics.pdf
Liberal Approach to the Study of Indian Politics.pdfLiberal Approach to the Study of Indian Politics.pdf
Liberal Approach to the Study of Indian Politics.pdf
WaniBasim
 
How to Setup Warehouse & Location in Odoo 17 Inventory
How to Setup Warehouse & Location in Odoo 17 InventoryHow to Setup Warehouse & Location in Odoo 17 Inventory
How to Setup Warehouse & Location in Odoo 17 Inventory
Celine George
 
Film vocab for eal 3 students: Australia the movie
Film vocab for eal 3 students: Australia the movieFilm vocab for eal 3 students: Australia the movie
Film vocab for eal 3 students: Australia the movie
Nicholas Montgomery
 
Main Java[All of the Base Concepts}.docx
Main Java[All of the Base Concepts}.docxMain Java[All of the Base Concepts}.docx
Main Java[All of the Base Concepts}.docx
adhitya5119
 
PCOS corelations and management through Ayurveda.
PCOS corelations and management through Ayurveda.PCOS corelations and management through Ayurveda.
PCOS corelations and management through Ayurveda.
Dr. Shivangi Singh Parihar
 
Digital Artefact 1 - Tiny Home Environmental Design
Digital Artefact 1 - Tiny Home Environmental DesignDigital Artefact 1 - Tiny Home Environmental Design
Digital Artefact 1 - Tiny Home Environmental Design
amberjdewit93
 
How to Build a Module in Odoo 17 Using the Scaffold Method
How to Build a Module in Odoo 17 Using the Scaffold MethodHow to Build a Module in Odoo 17 Using the Scaffold Method
How to Build a Module in Odoo 17 Using the Scaffold Method
Celine George
 
A Independência da América Espanhola LAPBOOK.pdf
A Independência da América Espanhola LAPBOOK.pdfA Independência da América Espanhola LAPBOOK.pdf
A Independência da América Espanhola LAPBOOK.pdf
Jean Carlos Nunes Paixão
 
The Diamonds of 2023-2024 in the IGRA collection
The Diamonds of 2023-2024 in the IGRA collectionThe Diamonds of 2023-2024 in the IGRA collection
The Diamonds of 2023-2024 in the IGRA collection
Israel Genealogy Research Association
 
Natural birth techniques - Mrs.Akanksha Trivedi Rama University
Natural birth techniques - Mrs.Akanksha Trivedi Rama UniversityNatural birth techniques - Mrs.Akanksha Trivedi Rama University
Natural birth techniques - Mrs.Akanksha Trivedi Rama University
Akanksha trivedi rama nursing college kanpur.
 
C1 Rubenstein AP HuG xxxxxxxxxxxxxx.pptx
C1 Rubenstein AP HuG xxxxxxxxxxxxxx.pptxC1 Rubenstein AP HuG xxxxxxxxxxxxxx.pptx
C1 Rubenstein AP HuG xxxxxxxxxxxxxx.pptx
mulvey2
 

Recently uploaded (20)

Pengantar Penggunaan Flutter - Dart programming language1.pptx
Pengantar Penggunaan Flutter - Dart programming language1.pptxPengantar Penggunaan Flutter - Dart programming language1.pptx
Pengantar Penggunaan Flutter - Dart programming language1.pptx
 
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...
 
RHEOLOGY Physical pharmaceutics-II notes for B.pharm 4th sem students
RHEOLOGY Physical pharmaceutics-II notes for B.pharm 4th sem studentsRHEOLOGY Physical pharmaceutics-II notes for B.pharm 4th sem students
RHEOLOGY Physical pharmaceutics-II notes for B.pharm 4th sem students
 
Your Skill Boost Masterclass: Strategies for Effective Upskilling
Your Skill Boost Masterclass: Strategies for Effective UpskillingYour Skill Boost Masterclass: Strategies for Effective Upskilling
Your Skill Boost Masterclass: Strategies for Effective Upskilling
 
Pollock and Snow "DEIA in the Scholarly Landscape, Session One: Setting Expec...
Pollock and Snow "DEIA in the Scholarly Landscape, Session One: Setting Expec...Pollock and Snow "DEIA in the Scholarly Landscape, Session One: Setting Expec...
Pollock and Snow "DEIA in the Scholarly Landscape, Session One: Setting Expec...
 
Chapter wise All Notes of First year Basic Civil Engineering.pptx
Chapter wise All Notes of First year Basic Civil Engineering.pptxChapter wise All Notes of First year Basic Civil Engineering.pptx
Chapter wise All Notes of First year Basic Civil Engineering.pptx
 
The basics of sentences session 6pptx.pptx
The basics of sentences session 6pptx.pptxThe basics of sentences session 6pptx.pptx
The basics of sentences session 6pptx.pptx
 
How to Create a More Engaging and Human Online Learning Experience
How to Create a More Engaging and Human Online Learning Experience How to Create a More Engaging and Human Online Learning Experience
How to Create a More Engaging and Human Online Learning Experience
 
How to deliver Powerpoint Presentations.pptx
How to deliver Powerpoint  Presentations.pptxHow to deliver Powerpoint  Presentations.pptx
How to deliver Powerpoint Presentations.pptx
 
Liberal Approach to the Study of Indian Politics.pdf
Liberal Approach to the Study of Indian Politics.pdfLiberal Approach to the Study of Indian Politics.pdf
Liberal Approach to the Study of Indian Politics.pdf
 
How to Setup Warehouse & Location in Odoo 17 Inventory
How to Setup Warehouse & Location in Odoo 17 InventoryHow to Setup Warehouse & Location in Odoo 17 Inventory
How to Setup Warehouse & Location in Odoo 17 Inventory
 
Film vocab for eal 3 students: Australia the movie
Film vocab for eal 3 students: Australia the movieFilm vocab for eal 3 students: Australia the movie
Film vocab for eal 3 students: Australia the movie
 
Main Java[All of the Base Concepts}.docx
Main Java[All of the Base Concepts}.docxMain Java[All of the Base Concepts}.docx
Main Java[All of the Base Concepts}.docx
 
PCOS corelations and management through Ayurveda.
PCOS corelations and management through Ayurveda.PCOS corelations and management through Ayurveda.
PCOS corelations and management through Ayurveda.
 
Digital Artefact 1 - Tiny Home Environmental Design
Digital Artefact 1 - Tiny Home Environmental DesignDigital Artefact 1 - Tiny Home Environmental Design
Digital Artefact 1 - Tiny Home Environmental Design
 
How to Build a Module in Odoo 17 Using the Scaffold Method
How to Build a Module in Odoo 17 Using the Scaffold MethodHow to Build a Module in Odoo 17 Using the Scaffold Method
How to Build a Module in Odoo 17 Using the Scaffold Method
 
A Independência da América Espanhola LAPBOOK.pdf
A Independência da América Espanhola LAPBOOK.pdfA Independência da América Espanhola LAPBOOK.pdf
A Independência da América Espanhola LAPBOOK.pdf
 
The Diamonds of 2023-2024 in the IGRA collection
The Diamonds of 2023-2024 in the IGRA collectionThe Diamonds of 2023-2024 in the IGRA collection
The Diamonds of 2023-2024 in the IGRA collection
 
Natural birth techniques - Mrs.Akanksha Trivedi Rama University
Natural birth techniques - Mrs.Akanksha Trivedi Rama UniversityNatural birth techniques - Mrs.Akanksha Trivedi Rama University
Natural birth techniques - Mrs.Akanksha Trivedi Rama University
 
C1 Rubenstein AP HuG xxxxxxxxxxxxxx.pptx
C1 Rubenstein AP HuG xxxxxxxxxxxxxx.pptxC1 Rubenstein AP HuG xxxxxxxxxxxxxx.pptx
C1 Rubenstein AP HuG xxxxxxxxxxxxxx.pptx
 

Purine degradation

  • 2. Steps involved in purine Degradation • The end product of purine metabolism in humans is uric acid. • The nucleotide monophosphates (AMP, IMP & GMP) are converted to their respective nucleoside forms (adenosine, inosine & guanosine) by the action of nucleotidase. • The amino group, either from AMP or adenosine, can be removed to produce IMP or ionosine.
  • 3. • Inosine & guanosine are converted to hypoxanthine & guanine (purine bases) by purine nucleoside phosphorylase. • Adenosine is not degraded by this enzyme, it has to be converted to inosine. • Guanine undergoes deamination by guanase to form xanthine. • Xanthine oxidase converts hypoxanthine to xanthine & xanthine to uric acid. • This enzyme contains FAD, molybdenum & iron. • It is exclusively found in liver & small intestine.
  • 4.
  • 5.
  • 6. Uric acid(2,6,8 trioxypurine) • It is final excretory product of purine metabolism in humans. • Uric acid can serve as an important antioxidant by getting itself converted (non- enzymatically) to allantoin. • It is believed that the antioxidant role of ascorbic acid in primates is replaced by uric acid.
  • 7. Degradation of Uric acid other than human beings. • Most animals (other than primates) oxidize uric acid by the enzyme uricase to allantoin, where the purine ring is cleaved. • Allantoin is then converted to allantoic acid & excreted in some fishes. • Further degradation of allantoic acid may occur to produce urea (in amphibians, most fishes & some molluscs) & to ammonia (in marine invertebrates).