Prion disease

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Theory linking prion, iron and creutzfeldt jakob disease.

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Prion disease

  1. 1. PrionCreutzfeldt-Jakoband IronSylvain Coutarel – December 2011
  2. 2. IntroductionSome definitions Creutzfeldt-Jakob : a degenerative neurological disorder (brain disease) that is incurable and invariably fatal.Sylvain Coutarel – December 2011
  3. 3. IntroductionSome definitions Prion: an infectious agent composed of protein in a misfolded form.Sylvain Coutarel – December 2011
  4. 4. Ferritin ComplexesSafe Ferritin Complexes Diferent RoleSylvain Coutarel – December 2011
  5. 5. Ferritin Complexes PrPSc-ferritin complexesSylvain Coutarel – December 2011
  6. 6. Ferritin Complexes BUT THERE IS STILL IRON FROM THE BEGINING!!! => Redox and alteration of cells!Sylvain Coutarel – December 2011
  7. 7. Solutions tracks!• A new biomarker for iron! • Make the PrPSc-ferritin complexes bio compatible! • Find a way to extract the iron from the PrPSc-ferritin complexes!Sylvain Coutarel – December 2011
  8. 8. Thanks for your attention!

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