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BIOENGINEERED NANOROBOTICS FOR CANCER THERAPY

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A person who is diagnosed with cancer will be offered a new alternative to chemotherapy because the traditional treatment of radiation that kills not just cancer cells but healthy human cells as well, causing hair loss, fatigue, nausea, depression, and a host of other symptoms. The application of nanorobotics can be considered as the better solution to this problems. Nanorobots are nanoelectromechanical systems designed to perform a specific task with precision at nanoscale dimensions. This technique involves the development of fully functional nanorobots capable of sensing, decision making, and actuation. From a bio inspired perspective, those in nanorobotics, including core design, propulsion and power generation, sensing, actuation, control, decision making, and system integration. The core of the nanorobots is a polysaccharide based nanoparticle, sensing and actuation ensure that it is capable of sensing and recognizing the cancer cell. These nanorobots may aid in cancer therapy, site-specific drug delivery, circulating diagnostics, advanced surgery, and tissue repair. One of the major advantages of nanorobots is it will not affect healthy cells in human body. Using strategies inspired from microorganisms, potential bioengineered nanorobots can be used for cancer therapy.

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BIOENGINEERED NANOROBOTICS FOR CANCER THERAPY

  1. 1. WELCOME 11/14/2015 1
  2. 2. BIOENGINEERED NANOROBOTICS FOR CANCER THERAPY 11/14/2015 2
  3. 3. OVERVIEW  Introduction  Nanorobots  Nanorobot Core  Power Supply  Propulsion  Sensing and Actuation  Control and Decision Making  Integration  Advantages  Disadvantages  Application  Conclusion 11/14/2015 3
  4. 4. Introduction Cancer Uncontrolled Growth Of Cells Spread all over the body It Cause death 11/14/2015 4
  5. 5. Treatment Kills Healthy Cells Fatigue Hair Loss  Radiation Therapy  Chemotherapy 11/14/2015 5
  6. 6. NanoRobots The technology of creating machines or robots at or close to the microscopic scale of a nanometer (10−9 meters). Nanorobots are devices made from DNA that are so small they can be injected into the bloodstream and carry a payload of drugs to specific cells. 11/14/2015 6
  7. 7. Cure Using Nanorobots  Inject nanorobots into patient  Detect cancer Cells  Destroy Cells  Do not affect on Healthy Cells 11/14/2015 7
  8. 8. Contd. Nano Infinitesimally Small Scale of Manufacturing And Fabricating Materials NanoRobot Tiny machine Perform specific task 11/14/2015 8
  9. 9. Nanorobot Core The core is a polysaccharide-based nanoparticle or cyclic peptide nanotube Cyclic peptide has ability to self-assemble into monodisperse nanotubes, are well suited to the core Capable of carrying a payload Allow the incorporation of propulsive, sensing and actuating components Float freely inside the body Detect the tumor effectively 11/14/2015 9
  10. 10. Core of Nanorobots 11/14/2015 10
  11. 11.  Cant use conventional sources  ATP released from core  Production of heat in the human body  Inclusion of electrodes in nanorobots and electrolytes in human blood will act as battery  Combination of chemical reactions in human blood and chemicals in nanorobots will lead to the formation of fuel source Power Supply 11/14/2015 11
  12. 12. Propulsion Fully functional flagella isolated from E.coli Artificial bacterial flagella(ABF) to move in 3D ABF are often fabricated from helical nanobelts with soft magnetic heads composed of Cr/Ni/Au It has ability to drive the nanorobots into the tumor tissue 11/14/2015 12
  13. 13. Sensing and Actuation  Capable of sensing and recognizing the targeted cancer cells  Chemical sensors which detect the target molecules  Aptamers (derived from the latin aptus, meaning to fit) are artificial nucleic acid (DNA or RNA)  Biomarkers can be specific cells, molecules, or genes, gene products, enzymes, or hormones. 11/14/2015 13
  14. 14. Schematic of the cyclic peptide nanorobot core with the aptamers designed for closing and locking the nanotube. 11/14/2015 14
  15. 15. Aptamer-target interaction 11/14/2015 15
  16. 16. Control and Decision Making  Use directional control, which is necessary for tumor targeting  Phototactic control to direct the nanorobot to the tumor location 11/14/2015 16
  17. 17. Integration First step is fabrication of power supply(ATP containing nanoparticle) Second step is load the power supply into the core Final step is attachment of propulsion system to the core 11/14/2015 17
  18. 18. Nanorobots can be used in blood cell to detect pathogens. 11/14/2015 18
  19. 19. Advantages Small Size Inexpensive(if mass produced) No maintenance Automated Painless Treatment Easily Disposable Affect only cancer cells Rapid elimination of disease. 11/14/2015 19
  20. 20. Disadvantage Initial Design Cost high Very complicate design 11/14/2015 20
  21. 21. Applications  Breaking up blood clots  Fighting cancer  Parasite Removal  Breaking up kidney stones 2011/14/2015
  22. 22. Conclusion With the introduction of nanorobots, humans can overcome many type of diseases It can also helpful in the detection of diseases Decision making nanorobots are the future of nanorobotic technology 11/14/2015 22
  23. 23. References  R. Baum, “Nanotechnology: Drexler and Smalley make the case for and against ‘molecular assemblers’,” Chem. Eng. News, vol. 81, pp. 37–42, 2003.  M. Sitti, “Microscale and nanoscale robotics systems [grand challenges of robotics],” IEEE Robot. Autom. Mag., vol. 14, no. 1, pp. 53–60, Mar. 2007.  https://en.wikipedia.org/wiki/Nanorobotics  http://hansmalab.physics.ucsb.edu/phys150/nanotech.pdf  http://nano-bio.ehu.es/files/nanorobots_work.pdf  http://www.roboticsbible.com/power-sources-of-nanorobots.html  http://icmr.nic.in/ijmr/2010/august/0803.pdf 11/14/2015 23
  24. 24. Thank You 11/14/2015 24

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