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OxStem || Dr Amy Varney || Novel Approaches to Cell Therapeutics and Regenerative Medicine

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Dr Amy Varney of OxStem joins us at the Science: Disrupt London Session on Future Health to talk about OxStem, an Oxford University spinout focusing on regenerative medicine through stem cells. She took us through not only their scientific thinking, but also their innovative business model which pairs disease with sub-company and keeps close ties to the University.

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OxStem || Dr Amy Varney || Novel Approaches to Cell Therapeutics and Regenerative Medicine

  1. 1. WWW.OXSTEM.CO.UK AN INTRODUCTION TO OXSTEM NOVEL APPROACHES TO CELL THERAPIES AND REGENERATIVE MEDICINE MARCH 2017
  2. 2. WWW.OXSTEM.CO.UK AGENDA 1.  OUR MISSION 2.  OUR GROUP 3.  OUR APPROACH TO CELL THERAPY & REGENERATIVE MEDICINE 4.  THE “STEMS” 2
  3. 3. WWW.OXSTEM.CO.UK OXSTEM •  OXSTEM IS A DEVELOPER OF CELL PROGRAMMING THERAPIES, WORKING IN CLOSE COLLABORATION WITH THE UNIVERSITY OF OXFORD. •  OXSTEM’S UNIQUE APPROACH TO REGENERATIVE MEDICINE WILL: Ø  DELIVER SMALL MOLECULE THERAPEUTICS THAT ACTIVATE REPAIR MECHANISMS THAT ALREADY EXIST WITHIN THE BODY Ø  EXPLOIT A DEEP UNDERSTANDING OF THE CHEMICAL UNDERPINNINGS OF STEM AND PROGENITOR CELL FUNCTION AND DIFFERENTIATION Ø  GENERATE A COLLECTION OF DRUG CANDIDATES TO AWAKEN ENDOGENOUS CELLS TO REPAIR TISSUES AFFECTED BY DISEASE OR INJURY •  TO BETTER HUMAN HEALTH BY DIRECTLY IMPACTING THE QUALITY AND DURATION OF LIFE •  OXSTEM WILL REVOLUTIONIZE THE REGENERATIVE MEDICINE FIELD BY DEVELOPING UNIQUE CELL PROGRAMMING THERAPIES TO TREAT DEGENERATIVE DISEASES WITH HIGH UNMET NEED WHAT WE DO OUR PURPOSE 3
  4. 4. WWW.OXSTEM.CO.UK AGENDA 1.  OUR MISSION 2.  OUR GROUP 3.  OUR APPROACH TO CELL THERAPY & REGENERATIVE MEDICINE 4.  THE “STEMS” 4
  5. 5. WWW.OXSTEM.CO.UK PROFESSOR STEVE DAVIES WAYNFLETE PROFESSOR OF CHEMISTRY OXFORD UNIVERSITY PROFESSOR ANGELA RUSSELL ASSOC. PROFESSOR OF CHEMISTRY & PHARMACOLOGY OXFORD UNIVERSITY PROFESSOR DAME KAY DAVIES DR LEE’S PROFESSOR OF ANATOMY OXFORD UNIVERSITY DR MICHAEL STEIN CHAIRMAN & CHIEF EXECUTIVE OFFICER RAYMOND SPENCER, CFA CHIEF FINANCIAL OFFICER EXECUTIVE FOUNDERS SCIENTIFIC FOUNDERS FOUNDING TEAM 5
  6. 6. WWW.OXSTEM.CO.UK “SPIN-IN” RAISED £16.9M IN MAY 2016 ACUTE MYELOID LEUKEMIA AND MYELO-DYSPLASTIC SYNDROME ALZHEIMER’S DISEASE TRAUMATIC BRAIN INJURY AGE RELATED MACULAR DEGENERATION MYOCARDIAL INFARCTION / HEART FAILURE “OxStem 4D” 3D STEM CELL SUSPENSION CULTURE GROUP STRUCTURE ALL >90% OWNED SUBSIDIARIES SPIN-OUT 6
  7. 7. WWW.OXSTEM.CO.UK INITIAL FUNDRAISE AND EARLY SUCCESS TIMELINE FOR YEAR 2016 7 MAY 2016: £16.9M ($20M) RAISED, A RECORD FOR OXFORD UNIVERSITY SPIN-OUTS MAY 2016: ESTABLISHMENT OF OXSTEM ONCOLOGY AND LAUNCH OF OXSTEM 4D OCTOBER 2016: WINNER OF THE NATIONAL BEST BIOTECHNOLOGY START-UP AT THE OBN AWARDS, UK DECEMBER 2016: PROOF-OF- PRINCIPLE DEMONSTRATED. FIRST EVER SMALL-MOLECULE DEMONSTRATING CELL-TO-WHOLE ANIMAL EFFICACY IN NEUROGENESIS AUGUST 2016: ESTABLISHMENT OF OXSTEM NEURO AND OXSTEM OCULAR NOVEMBER 2016: ESTABLISHMENT OF OXSTEM CARDIO 2016
  8. 8. WWW.OXSTEM.CO.UK AGENDA 1.  OUR MISSION 2.  OUR GROUP 3.  OUR APPROACH TO CELL THERAPY & REGENERATIVE MEDICINE 4.  THE “STEMS” 8
  9. 9. WWW.OXSTEM.CO.UK PLAGUED WITH TOLERANCE ISSUES AND REJECTION; REQUIRE SPECIALIST FACILITIES FOR THERAPEUTIC DELIVERY INTRODUCTION TO CELL THERAPY AND REGENERATIVE MEDICINE CURRENT THERAPEUTIC PARADIGMS TISSUE ENGINEERING THERAPY VIA IMPLANTATION CELL TRANSPLANTATION THERAPY VIA IMPLANTATION SOURCE: CULME-SEYMOUR ET AL., REGEN. MED. 2012 9
  10. 10. WWW.OXSTEM.CO.UK DRUG HERE TO INFLUENCE PROGRESS DRUG HERE TO INFLUENCE PROGRESS NATURALLY OCCURRING COMMITTED ADULT STEM CELLS NATURALLY OCCURRING ADULT STEM CELLS FUNCTIONAL CELLS FOR REGENERATIVE TREATMENT NATURALLY OCCURRING ADULT STEM CELLS OXSTEM’S APPROACH: PROGRAMMABLE CELL CHEMISTRY 10
  11. 11. WWW.OXSTEM.CO.UK ACTIVATION OF RESIDENT CELLS IN VIVO TO ALLEVIATE DISEASE •  SALAMANDERS, AND OTHER AMPHIBIANS, REGENERATE TISSUE AND REGROW DETACHED LIMBS •  IN HUMANS MANY CELL TYPES ARE CONTINUOUSLY REPLACED INTO ADULTHOOD: Ø  BLOOD/BONE Ø  GUT EPITHELIUM Ø  SKIN/HAIR •  OTHER TISSUES RETAIN A LIMITED REGENERATIVE CAPACITY (IN RESPONSE TO INJURY): Ø  CARDIAC MUSCLE Ø  NEURONS Ø  RETINA •  IN ONCOLOGY, CANCER STEM-LIKE CELLS BECOME ABERRANT à UNLIMITED GROWTH AND/OR ARREST OF DIFFERENTIATION OXSTEM WILL ACTIVATE AND ENHANCE NATURAL REPAIR PROCESSES IN THE BODY, THAT ARE USUALLY VERY SLOW BY USING SMALL MOLECULE DRUGS AS WELL AS REDIRECTING CANCER STEM-LIKE CELLS TOWARDS A BENIGN (DIFFERENTIATED) PHENOTYPE 11
  12. 12. WWW.OXSTEM.CO.UK AGENDA 1.  OUR MISSION 2.  OUR GROUP 3.  OUR APPROACH TO CELL THERAPY & REGENERATIVE MEDICINE 4.  THE “STEMS” – SEE WEBSITE: WWW.OXSTEM.CO.UK 12

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