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Reflex Sympathetic Dystrophy (CRPS 1)


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Reflex Sympathetic Dystrophy (CRPS 1)

  1. 1. Sayantika DharReflex Sympathetic Dystrophy (CRPS I)
  2. 2. Sayantika Dhar Definition:• Complex regional pain syndrome (CRPS) is a chronic  progressive disease characterized by severe pain,  swelling and changes in the skin. [1]• It often affects an arm or a leg and may spread to  another part of the body.• Though treatment is often unsatisfactory, early  multimodal therapy can cause dramatic  improvement or remission of the syndrome in some  patients. [1] Hunter, Mackin, Callahan. Rehabilitation of the Hand and Upper Extremity, 5th Edn, Ch 104, Pg:1695
  3. 3. Sayantika Dhar Classification:The International Association for the Study of Pain has  proposed dividing CRPS into two types based on the  presence of nerve lesion following the injury.• Type I, formerly known as reflex sympathetic dystrophy (RSD), does not have demonstrable nerve  lesions.• Type II, formerly known as causalgia, has evidence of  obvious nerve damage.
  4. 4. Sayantika Dhar Synonyms for CRPS:• Algodystrophy• Mimocausalgia• Peripheral trophoneurosis• Posttraumatic sympathetic dystrophy• Reflex neurovascular dystrophy• Shoulder-hand syndrome• Sudeck’s atrophy• Sympathetic neurovascular dystrophy
  5. 5. Sayantika DharCRPS I: Reflex Sympathetic Dystrophy• RSD is a somewhat generic term used to  describe post traumatic pain accompanied by  inappropriate autonomic activity and impaired  extremity function.
  6. 6. Sayantika IASP Definition Dhar (International Association for the Study of Pain)"CRPS Type I is a syndrome that usually developsafter an initiating noxious event, is not limited tothe distribution of a single peripheral nerve, and isapparently disproportioned to the inciting event. Itis associated at some point with evidence of edema,changes in skin blood flow, abnormal sudomotoractivity in the region of the pain, or allodynia orhyperalgesia"
  7. 7. Sayantika Dhar Susceptibility• CRPS can strike at any age, but the mean age at  diagnosis is 42.• CRPS has been diagnosed in children as young as 2  years old.•  It affects both men and women; however, CRPS is 3  times more frequent in females than males.• Investigators estimate that 2-5 percent of those with  peripheral nerve injury, and 13-70 percent of those  with hemiplegia will suffer from CRPS.
  8. 8. Sayantika Symptoms: Dhar• The most common symptoms overall are burning  and electrical sensations, described to be like  "shooting pain". • muscle spasms• local swelling, abnormally increased sweating• changes in skin temperature (usually hot but  sometimes cold) • Changes in color (bright red or a reddish violet)• softening and thinning of bones• joint tenderness or stiffness, • and/or restricted or painful movement.
  9. 9. Sayantika DharStages of Progression:
  10. 10. Sayantika Dhar Stage 1• Stage one is characterized by severe, burning  pain at the site of the injury. • Muscle spasm• joint stiffness• restricted mobility• rapid hair and nail growth, and • vasospasm
  11. 11. Sayantika Dhar Stage 2• Stage two is characterized by more intense pain. • Swelling spreads• hair growth diminishes• nails become cracked, brittle, grooved, and  spotty • osteoporosis becomes severe and diffuse• joints thicken• muscles atrophy.
  12. 12. Sayantika Dhar Stage 3• Stage three is characterized by irreversible  changes in the skin and bones• Pain-unyielding, may involve the entire limb• marked muscle atrophy• severely limited mobility of the affected area• flexor tendon contractures• marked bone softening and thinning
  13. 13. Sayantika DharDiagnosis:
  14. 14. Sayantika Dhar The International Association for the Study of Pain (IASP) lists the diagnostic criteria for RSD as follows:1. The presence of an initiating noxious event or a cause of immobilization2. Continuing pain, allodynia (perception of pain from a nonpainful stimulus), or hyperalgesia (an exaggerated sense of pain)3. Evidence at some time of edema, changes in skin blood flow4. The diagnosis is excluded by the existence of any condition that would otherwise account for the degree of pain and dysfunction.
  15. 15. Sayantika Dhar Thermography• Use of infrared radiation to view or locate over heated parts of the limb.• Not a reliable tool for diagnosis• Results affected by smoking, drinking coffee, recent physical activity, topical lotions and creams, etc.
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  18. 18. Sayantika Dhar Yoichi Koike, Hirotaka Sano. Changes with time in skin temperature of the shoulders in healthy controls and a patient with shoulder-hand syndrome. Upsala Journal of Medical Sciences. 2010; 115: 260–265“A thermography is unable to capture temperature changes over time. In contrast, a Thermocron is an effective measuring device to monitor temperature changes over time.Thermocron is a more effective way to detect shoulder skin temperature abnormalities in a patient with shoulder-hand syndrome.
  19. 19. Sayantika Dhar Sweat testing• A powder that changes color when exposed to sweat can be applied to the limbs• However, this method does not allow for quantification of sweating.
  20. 20. Sayantika Dhar Radiography• Patchy osteoporosis- detected through X-ray imagery- as early as two weeks after onset.• A bone scan of the affected limb may detect these changes even sooner.• Bone densitometry can also be used to detect changes in bone mineral density.
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  22. 22. Sayantika Dhar Electrodiagnostic testing• EMG should not be done for the diagnosis of CRPS I or II.• It is extremely painful for patients suffering from CRPS and may even be considered unethical and cruel.
  23. 23. Sayantika DharAssessment:
  24. 24. Sayantika Dhar• Presenting signs and symptoms: – Pain, including spontaneous burning pain, allodynia, hyperalgia. – Sensory hyperasthesia – Tissue abnormality, including vasomotor instability, edema, skin color changes, subcutaneous bone and joint changes. – Motor changes, including decreased ROM and weakness and movement disorders (tremor, dystonia and neglect)
  25. 25. Sayantika Dhar Hand & Orthopedic Rehabilitation services Pain profilePAIN QUALIFIERS JOINT PAIN Aching 0= no pain Burning 1= mild pain with deep palpation Cramping Heaviness/fatigue 2= severe pain with deep palpation Numbness 3= severe pain with mild palpation Sharp/stabbing 4= hyperesthesia Stiffness Swelling Throbbing Tingling/pins and needles Weakness Other ______________
  26. 26. Sayantika Dhar• VAS; 10 cms line.• Body chart:
  27. 27. Sayantika Dhar Sensory evaluation • Cutaneous Pressure SensationPathology Fingertip (mg) Thumb (mg) Palm (mg)Normal 2.36-2.83 2.36-2.83 2.44-2.83Diminished Light 3.22-3.61 3.22-3.61 3.22-3.84touchDiminished 3.84-4.31 3.84-4.31 4.07-4.56Protective sensationLoss of Protective 4.56-6.65 4.56-6.65 4.74-6.65sensation
  28. 28. Sayantika DharDifferential Diagnosis:
  29. 29. Sayantika DharMichael Stanton-Hicks. Complex regional painsyndrome. Anesthesiology Clin N Am 21 (2003) 733–744.The distinction between CRPS I and II is theevidence of a definable nerve lesion. The signsand symptoms for both conditions, however,are clinically indistinguishable.
  30. 30. Sayantika DharMANAGEMENT
  31. 31. Sayantika Dhar Pharmacological interventions:Physicians use a variety of drugs to treat RSD• antidepressants• anti-inflammatory such as corticosteroids• COX-inhibitors such as piroxicam,• vasodilators• GABA analogs such gabapentin and pregabalin,• alpha- or beta-adrenergic-blocking compounds, and the entire pharmacy of opioids.
  32. 32. Sayantika Dhar Invasive techniques: Local anaesthetic blocks/injections• Injection of lidocaine is often the first step in treatment.• Injections are repeated as needed.• Results- short lasting.
  33. 33. Sayantika Dhar Spinal cord stimulators• Neurostimulation (spinal cord stimulator) may also be surgically implanted to reduce the pain by directly stimulating the spinal cord.• These devices place electrodes either in the epidural space or directly over nerves located outside the central nervous system.
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  35. 35. Sayantika Dhar Drug pump• Implantable drug pumps may also be used to deliver pain medication directly to the cerebrospinal fluid which allows powerful opioids to be used in a much smaller dose than when taken orally.
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  37. 37. Sayantika Dhar Sympathectomy• Surgical, chemical, or radiofrequency sympathectomy — interruption of the affected portion of the sympathetic nervous system — can be used as a last resort
  38. 38. Sayantika DharPhysiotherapy Management:• Goal: ‘symptomatic treatment’
  39. 39. Sayantika Dhar Pain• TENS• Thermal agents• Cryotherapy• Vibration• Splinting-dynamic• CPM
  40. 40. Sayantika Dhar Edema• Elevation• Soft tissue manipulations• Active exercises• Compression- continuous
  41. 41. Sayantika Dhar Allodynia• Vibration• Massage• Progressive weight bearing• Contrast bath• Desensitization – Peripheral to central – Fine texture to coarse texture
  42. 42. Sayantika Dhar Dystonia and joint stiffness• Biofeedback and activities• Active exercises• Splinting – Dynamic: pain and motion – Static: prevention, assist weak muscles – Static progressive: joint stiffness, tissue contracture• CPM• Modalities – Superficial heat with gentle stretch – Ultrasound with gentle stretch
  43. 43. Sayantika Dhar Vasomotor instability• Low-impact aerobic activities• Thermal biofeedback Vasoconstriction Vasodilation Thermal agents Cryotherapy Massage TENS Ultrasound Neural mobilization TENS(burst) Patient education- alcohol Patient education- caffiene/nicotine intake
  44. 44. Sayantika Dhar Volker et al. Interaction of Hyperalgesia and Sensory Loss in Complex Regional Pain Syndrome Type I. July 2008, Volume 3, Issue 7, e2742. They proposed three pathomechanisms of CRPS I, which follow a distinct time course:• Thermal hyperalgesia, observed in acute CRPS, indicates an ongoing aseptic peripheral inflammation.• Thermal hypoaesthesia, as detected in acute and chronic CRPS, signals a degeneration of A-delta and C-fibres, which further deteriorates in chronic CRPS.• Paradoxical Heat Sensation(PHS) in acute CRPS I indicates that both inflammation and degeneration are present, whilst in chronic CRPS I, the pathomechanism of degeneration dominates, signalled by the absence of PHS. Conclusion: Acute CRPS I :- Heat and Cold Pain thresholds reduced but Warm and Cold Detection thresholds were normal Chronic CRPS I :- Thermal hyperalgesia declined. But Warm and Cold Detection thresholds deteriorated.
  45. 45. Sayantika DharThacker, M., Gifford, L., 2002. A review of physiotherapymanagement of complex regional pain syndrome. TopicalIssues in Pain, Vol. 3. CNS Press, Falmouth, pp. 119–141.Use of electrotherapy may cause moresymptoms in patients with mechanicalallodynia through stimulation of largemyelinated A fibers
  46. 46. Sayantika Dhar Chang-Zern Hong. Specific sequential Myofascial Trigger Point therapy in the treatment of a patient with Myofascial Pain syndrome with reflex Sympathetic dystrophy. ACO. Vol 9, No.1, March 2000. MTrP for- wrist and finger extensors and anterior deltoid were commenced. MTTrP can be used along with:o Intermittent cold (sprays or ice massage)o Stretching and post isometric relaxationo Deep pressure soft tissue massageo Thermotherapyo Trigger point injections with local anaesthetic solution or dry needling on trigger points.
  47. 47. Sayantika DharTHANK YOU