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Presented by:
Sasikiran Marri
B.Pharmacy -3rd year
NICP - JNTU Ananthapur
INTRODUCTION
o Peptic / Stomach ulcer is the condition in which imbalance of aggressive factor
and defensive factors.
o These ulcers has been caused by the bacteria.
o The main goal of anti-ulcer drug is that to decreasing the level of gastric acidity or
enhancing mucosal protection.
o For infection agent new approaches was found in order to prevention of infection
of micro organism.
WHAT IS PEPTIC ULCER?
➢ Peptic / stomach ulcer is the condition ion which imbalance of aggressive factor
and defensive factors.
➢ AGGRESSIVE FACTOR : Gastric acid, gastrin pepsin.
➢ DEFENSIVE FACTOR : Prostaglandin, mucosa, bicarbonate.
COMMON RISK FACTORS
✓ Abdominal pain, classically Epigastric with severity relating to mealtimes, after
around 3 hours of taking a meal.
✓ Loss of appetite and weight loss.
✓ Waterbrash ( rush of saliva after an episode of
regurgitation to dilute the acid in esophagus ).
✓ Nausea, and Copious Vomiting
PHARMACOKINETICS
▪ Absorbed rapidly and completely except for famotidine; food and
antacids may reduce absorption; distributed widely throughout the body;
metabolized by the liver; excreted primarily in the urine.
❑ Pharmacokinetic
✓ Bioavailability : - 50% ( instability at acidic pH )
✓ Metabolism : In liver ( CYP2C19 and CYPsA4 )
✓ Excretion : Metabolites excreted through renally
✓ Onset action : ½-1 hour
✓ Duration of action : 24 hours
❑ ADVERSE EFFECTS
✓ Hepatic Dysfunction
✓ Dizziness
✓ Nausea
✓ Headache
❑ INTERACTION
✓ Inhibits oxidation of certain drugs : diazepam, Phenytoin, Warfarin
➢ Goodman & Gilman’s. Manual of pharmacology & Therapeutic; 11th Edn.2008.
➢ MacGraw’s Hill, Jaypee brothersbpublication.
➢ Philadelphia:376-379.
➢ www.wikepedia/antiulcer.
REFERENCE
Antiulcer Drugs

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Antiulcer Drugs

  • 1. Presented by: Sasikiran Marri B.Pharmacy -3rd year NICP - JNTU Ananthapur
  • 2. INTRODUCTION o Peptic / Stomach ulcer is the condition in which imbalance of aggressive factor and defensive factors. o These ulcers has been caused by the bacteria. o The main goal of anti-ulcer drug is that to decreasing the level of gastric acidity or enhancing mucosal protection. o For infection agent new approaches was found in order to prevention of infection of micro organism.
  • 3. WHAT IS PEPTIC ULCER? ➢ Peptic / stomach ulcer is the condition ion which imbalance of aggressive factor and defensive factors. ➢ AGGRESSIVE FACTOR : Gastric acid, gastrin pepsin. ➢ DEFENSIVE FACTOR : Prostaglandin, mucosa, bicarbonate.
  • 4. COMMON RISK FACTORS ✓ Abdominal pain, classically Epigastric with severity relating to mealtimes, after around 3 hours of taking a meal. ✓ Loss of appetite and weight loss. ✓ Waterbrash ( rush of saliva after an episode of regurgitation to dilute the acid in esophagus ). ✓ Nausea, and Copious Vomiting
  • 5. PHARMACOKINETICS ▪ Absorbed rapidly and completely except for famotidine; food and antacids may reduce absorption; distributed widely throughout the body; metabolized by the liver; excreted primarily in the urine.
  • 6. ❑ Pharmacokinetic ✓ Bioavailability : - 50% ( instability at acidic pH ) ✓ Metabolism : In liver ( CYP2C19 and CYPsA4 ) ✓ Excretion : Metabolites excreted through renally ✓ Onset action : ½-1 hour ✓ Duration of action : 24 hours ❑ ADVERSE EFFECTS ✓ Hepatic Dysfunction ✓ Dizziness ✓ Nausea ✓ Headache ❑ INTERACTION ✓ Inhibits oxidation of certain drugs : diazepam, Phenytoin, Warfarin
  • 7. ➢ Goodman & Gilman’s. Manual of pharmacology & Therapeutic; 11th Edn.2008. ➢ MacGraw’s Hill, Jaypee brothersbpublication. ➢ Philadelphia:376-379. ➢ www.wikepedia/antiulcer. REFERENCE