CNS Tumors
Classification
-

Gliomas
o

Astrocytoma
•
•

o
o

-

Medulloblastoma

Other parenchymal tumors
o
o

-

Central neurocytom...
Which Tumor ?
35 year old man complained of headache for the
past 2 years , he also been having weakness in
his left upper...
Which Tumor ?
A mother brings her 5 year old son to the
neurologist, he has been having tremors and
was ataxic. MRI is sho...
Glioblastoma
Glioblastoma
BRAIN TUMORS
•

Gross: Cyst filled with gelatinous material, and mural nodule. Micro: Cells with
long, hair-like processes...
WHO grading (biologic behavior) Astrocytomas (I - IV)

Pilocytic (I / IV)

Well-differentiated (II / IV)

Anaplastic (III ...
Oligodendroglioma G II
Ependymoma G II
Medulloblastoma

A

C

B
Meningioma G I
Schwannoma G I
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Week 10 objective

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  • Well differentiated Astrocytoma progressed to anaplastic and glioblastomamultiforme
  • Pilocytic astrocytoma
  • Week 10 objective

    1. 1. CNS Tumors
    2. 2. Classification - Gliomas o Astrocytoma • • o o - Medulloblastoma Other parenchymal tumors o o - Central neurocytoma Ganglioglioma Dysembryoplastic neuroepithelial tumor Poorly Differentiated Neoplasms o - Oligodendroglioma Ependymoma Neuronal Tumors o o o - Fibrillary Pilocytic Primary CNS lymphoma Germ cell tumors Meningioma Shwannoma Metastatic tumors
    3. 3. Which Tumor ? 35 year old man complained of headache for the past 2 years , he also been having weakness in his left upper limb , he came to the neurologist because he had a seizure yesterday. MRI was performed ; mass in his cerebral hemisphere. he started chemotherapy and radiotherapy as resection was not feasible , 11 months later he passed away .
    4. 4. Which Tumor ? A mother brings her 5 year old son to the neurologist, he has been having tremors and was ataxic. MRI is shown . The tumor was resected. Histologic features of it : GFAP +ve Rosenthal fibers. Source :http://emedicine.medscape.com/article/985927-workup#a0720
    5. 5. Glioblastoma
    6. 6. Glioblastoma
    7. 7. BRAIN TUMORS • Gross: Cyst filled with gelatinous material, and mural nodule. Micro: Cells with long, hair-like processes, Rosenthal fibers. GFAP positive Pilocytic astrocytoma, grade I / IV
    8. 8. WHO grading (biologic behavior) Astrocytomas (I - IV) Pilocytic (I / IV) Well-differentiated (II / IV) Anaplastic (III / IV) Glioblastoma (IV / IV)
    9. 9. Oligodendroglioma G II
    10. 10. Ependymoma G II
    11. 11. Medulloblastoma A C B
    12. 12. Meningioma G I
    13. 13. Schwannoma G I

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