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Rsqrd AI: Application of Explanation Model in Healthcare

In this talk, Jasmine Wilkerson talks about the need for explainability in healthcare. Presented on 06/06/2019 **These slides are from a talk given at Rsqrd AI. Learn more at rsqrdai.org**

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Jasmine	Wilkerson
jasminewilkerson@gmail.com
Application	of	Explanation	
Model	In	Healthcare
Agenda
• Why	Explanation	Model
• Which	Explanation	models
• Internal	vs	external	application
Interpretable	machine	learning
• Explanations of	AI/machine	learning	models	to	humans with	domain	knowledge
[Craik 1967, Doshi-Velez 2014]
• Why	is	the	prediction	being	made?
• Comprehensible	to	humans	in	
• (i)	natural	language	
• (ii)	easy	to	understand	representations
Why	do	we	need	explanation	model?
• When	fairness	is	critical:		
• Any	context	where	humans	are	required	to	provide	explanations	so	that	people	cannot	
hide	behind	machine	learning	models	[Al-Shedivat 2017B, Doshi-Velez 2014]
• When	consequences	are	far-reaching:	
• Predictions	can	have	far	reaching	consequences	e.g.,	recommend	an	operation,	
recommend	sending	a	patient	to	hospice	etc.
• When	the	cost	of	a	mistake	is	high:
• Ex:	misclassification	of	a	malignant	tumor	can	be	costly	and	dangerous
• When	a	new/unknown	hypothesis	is	drawn:	
• “It's	not	a	human	move.	I've	never	seen	a	human	play	this	move.”	[Fan Hui]
• Pneumonia	patients	with	asthma	had	lower	risk	of	dying	[Caruana 2015]
Why	do	we	need	explanation	model?
Well,	the	computer	
assures	me	that	you	are	
fine	and	it	has	given	me	
100	reasons	for	it.
Doctor,	are	you	sure	
that	I	am	ok	now?	My	
head	still	hurts.
Why	do	we	need	explanation	model?
• Understanding	end-to-end	application	criteria	
o Who	are	the	end	users
o Scoring	scenarios
o Engineering	requirements
o Model	Properties
Explanation	Model Local	
(n=1)
Global	
(n=N)
Explanation	Type Model	Specificity
LIME X Relative	Importance Agnostic
SHAP	Kernel	
Explainer
X X Relative	Importance Agnostic
SHAP	Tree	Explainer X X Relative	Importance Tree	Based	Models
GAM X Graphical Self
GA2M X Graphical Self
ICE	Plots X Graphical Agnostic
Partial	Dependence	
Plots
X Graphical Agnostic
Model	Distillation X Graphical Agnostic
Logistic	Regression X Relative	Importance Self
Decision	Trees X Rules Self
XGB	Explainer X Relative	Importance XGBoost
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Rsqrd AI: Application of Explanation Model in Healthcare