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BY SANDRA MANGUNSONG
PATHWAYS TO
GRACEFUL AGING
AGENDA
PATHWAYS
TO
GRACEFUL
AGING
2
HALLMARKS OF AGING
BENEFIT OF FASTING
METABOLIC FLEXIBILITY
PROLONGED FASTING
HALLMARKS OF
AGING
PATHWAYS
TO
GRACEFUL
AGING
3
Primary Hallmarks
Genomic instability
Telomere attrition
Epigenetic alterations
Loss of proteostasis
Antagonistic hallmarks
Deregulated nutrient-sensing
Mitochondrial dysfunction
Cellular senescence
Integrative hallmarks
Stem cell exhaustion
Altered extracellular communication
HALLMARKS OF
AGING
PATHWAYS
TO
GRACEFUL
AGING
4
Primary Hallmarks
Genomic instability
Telomere attrition
Epigenetic alterations
Loss of proteostasis
Antagonistic hallmarks
Deregulated nutrient-sensing
Mitochondrial dysfunction
Cellular senescence
Integrative hallmarks
Stem cell exhaustion
Altered extracellular communication
BENEFIT OF FASTING
PATHWAYS
TO
GRACEFUL
AGING
5
• MORE FOCUS
• METABOLIC SWITCH
• BALANCING THE CHOLESTEROL
LEVEL
• FATTY LIVER
• IMPROVE INSULIN SENSITIVITY
• MORE ENERGY
• IMPROVED LIFE SPAN
• LOWER INFLAMMATION
• INCREASE HUMAN GROWTH
FACTOR
• ACTIVATE AUTOPHAGY
Who should
avoid Fast
PATHWAYS
TO
GRACEFUL
AGING
6
• History with Eating Disorder
• Pregnant or during
breastfeeding
• Young children
• Type 1 diabetes
• Athletes who are in Season
• Under medication
• Underweight
• another diets
PROLONGED FASTING
PATHWAYS
TO
HEALTH
7
KNOWING YOUR FASTING-
GOAL.
BASELINE VALUES
MONITOR YOUR PROGRESS
LISTEN TO BODY SIGNS
KNOW WHEN YOU SHOULD
STOP
FASTING GOAL
PATHWAYS
TO
GRACEFUL
AGING
8
BLOOD GLUCOSE
AUTOPHAGY
WEIGHT LOSS/KETOSIS
LEVEL
STEM CELLS
SANDRA@MANGUNSONG.COM

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Graceful_Aging_short.pptx

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  3. Proses penuan Pada dasarnya: Sel sel didalam tubuh itu proses perang antara kerusakan dan perbaikan. Dalam perang, kadang ada yg menang kada ada yang kalah. Ini menyebabkan terjadinya perubahan seluler dan mlekuler yang terakumulasi dari waktu ke waktu yg menjadi peran utama dalam proses penuaan Ada sembilan tanda penuaan yang digambarakan disini: (Carlos Lopez Otin) (satu sama lain bisa berhubungan)