What is different about activities on the two
sides of the synapse (axon next to muscle or
dendrite of other nerve)?
SALMA...
Contents
o Introduction
o Nerve Cell
o Synapse
o Transmission across the synapse----- Neuromuscular
junction (NMJ)
o Summa...
Introduction
o Neuron-----electrically excitable cell-----processing and
transmitting information through electrical and c...
NERVE CELL
Three parts of a nerve cell are:
o dendrites: branches that receive sensory input and
bring it to the neuron’s ...
Parts of a Nerve cell
http://cnx.org/content/m44731/latest/?collection=col11448/latest
SYNAPSE
SYNAPSE
 The presynaptic cell ends in an axon terminal that contains
calcium channels and synaptic vesicles with
neurotra...
Transmission across the synapse-----
Neuromuscular junction (NMJ)
o “ The place where the motor neuron makes a functional
...
Neuromuscular Junction
What is the
mechanism of
Neuromuscular
Transmission
Myasthenia Gravis, A Seminar Report Posted: September 21, 2010 in Physiology, Toxic Med
From LIFE: The Science of Biology (Sadava et al., 2010)
Fate of Acetylcholine
Summary
 The synapse is a connection between a neuron and its
target cell (which is not necessarily a neuron).
 The pres...
What is different about activities on the two sides of the synapse?
What is different about activities on the two sides of the synapse?
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What is different about activities on the two sides of the synapse?

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What is different about activities on the two sides of the synapse?

  1. 1. What is different about activities on the two sides of the synapse (axon next to muscle or dendrite of other nerve)? SALMAN UL ISLAM 2013298039 31.03.2014
  2. 2. Contents o Introduction o Nerve Cell o Synapse o Transmission across the synapse----- Neuromuscular junction (NMJ) o Summary
  3. 3. Introduction o Neuron-----electrically excitable cell-----processing and transmitting information through electrical and chemical signals. o Neurons communicate with each other by synaptic transmission. o Synapses transmit, process, and store information in brain. Courtesy of the Südhof lab. See Südhof, T.C. 2008. Nature 455:903-911 for details.
  4. 4. NERVE CELL Three parts of a nerve cell are: o dendrites: branches that receive sensory input and bring it to the neuron’s cell body; o cell body: contains the nucleus, mitochondria, and ribosomes. The cell body carries on the normal metabolic cellular functions of the nerve cell. o axon: a long fiber extending from the cell body. The role of the axon is to transmit a nerve impulse to another cell. http://highered.mcgraw-hill.com/sites/dl/free/0073403474/858357/answers2e_ch25.doc.
  5. 5. Parts of a Nerve cell http://cnx.org/content/m44731/latest/?collection=col11448/latest
  6. 6. SYNAPSE
  7. 7. SYNAPSE  The presynaptic cell ends in an axon terminal that contains calcium channels and synaptic vesicles with neurotransmitters.  The postsynaptic cell has ion channels with receptors for the neurotransmitters.  Between the two cells is a small gap called the synaptic cleft. http://highered.mcgraw-hill.com/sites/dl/free/0073403474/858357/answers2e_ch25.doc.
  8. 8. Transmission across the synapse----- Neuromuscular junction (NMJ) o “ The place where the motor neuron makes a functional contact with the skeletal muscle cell is called NEUROMUSCULAR JUNCTION or MYONEURAL JUNCTION”
  9. 9. Neuromuscular Junction
  10. 10. What is the mechanism of Neuromuscular Transmission
  11. 11. Myasthenia Gravis, A Seminar Report Posted: September 21, 2010 in Physiology, Toxic Med
  12. 12. From LIFE: The Science of Biology (Sadava et al., 2010)
  13. 13. Fate of Acetylcholine
  14. 14. Summary  The synapse is a connection between a neuron and its target cell (which is not necessarily a neuron).  The presynaptic element is the synaptic end bulb of the axon where Ca2+ enters the bulb to cause vesicle fusion and neurotransmitter release.  The neurotransmitter diffuses across the synaptic cleft to bind to its receptor.  Resulting action potential leads to muscle contraction.  The neurotransmitter is cleared from the synapse either by enzymatic degradation or neuronal reuptake.

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