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UK startups are less confident than a year ago that business conditions will improve. Most say a split from the EU would have a negative impact on the UK innovation economy. Ongoing unpredictability is likely to affect access to talent, international trade and international capital. Still, innovation is moving ahead. A large majority of startups report healthy domestic fundraising and 2019 hiring plans. More good news: Women are moving into startup leadership positions. Looking ahead, we asked which technologies will have the most promise in a decade: UK startups say AI, digital health and life science.