17. drugs for skin conditions


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17. drugs for skin conditions

  1. 1. Chapter 17 Drugs for Skin Conditions Copyright © 2011 Delmar, Cengage Learning
  2. 2. Basic Anatomy and Physiology <ul><li>The skin is made up of three layers: </li></ul><ul><ul><li>Epidermis (the most superficial layer that contains cells, but not blood vessels) </li></ul></ul><ul><ul><li>Dermis (the middle layer that is composed of blood and lymph vessels, nerve fibers, and the accessory organs of skin such as glands and hair follicles) </li></ul></ul><ul><ul><li>Subcutaneous (the deepest layer that is composed of connective tissue) </li></ul></ul>Copyright © 2011 Delmar, Cengage Learning
  3. 3. Basic Anatomy and Physiology Copyright © 2011 Delmar, Cengage Learning
  4. 4. Drugs Used in Treating Skin Disorders <ul><li>Topical treatments consist of agents applied to a surface; they affect the area to which they are applied </li></ul><ul><ul><li>Topical antibiotics and antifungals are covered in Table 17-1 in your textbook </li></ul></ul><ul><li>Systemic treatments consist of drugs given systemically that affect many areas of the body </li></ul><ul><ul><li>Covered in a variety of previous chapters </li></ul></ul>Copyright © 2011 Delmar, Cengage Learning
  5. 5. Drugs Used in Treating Pruritus <ul><li>Topical antipruritics provide moderate relief of itching (may be used with systemic medication) </li></ul><ul><ul><li>Topical nonsteroidal antipruritics </li></ul></ul><ul><ul><ul><li>Local anesthetics such as lidocaine, tetracaine, benzocaine, and pramoxine </li></ul></ul></ul><ul><ul><li>Soothing agents </li></ul></ul><ul><ul><ul><li>Oatmeal has soothing and anti-inflammatory effects </li></ul></ul></ul><ul><ul><li>Antihistamines </li></ul></ul><ul><ul><ul><li>Products containing diphenhydramine calm pain and itching due to allergic reactions and sensitive skin </li></ul></ul></ul><ul><ul><li>Topical corticosteroids </li></ul></ul><ul><ul><ul><li>Variety of products such as hydrocortisone, fluocinolone, triamcinolone, and betamethazone </li></ul></ul></ul>Copyright © 2011 Delmar, Cengage Learning
  6. 6. Drugs Used in Treating Seborrhea <ul><li>Seborrhea is characterized by abnormal flaking or scaling of the epidermis and may be accompanied by increased oil production (seborrhea oleasa) or not (seborrhea sicca) </li></ul><ul><li>Keratolytics are an important group of antiseborrheics </li></ul><ul><ul><li>Keratolytics remove excess keratin and promote loosening of the outer layers of the epidermis </li></ul></ul><ul><ul><li>Keratolytics break down the protein structure of the keratin layer, permitting easier removal of this material </li></ul></ul>Copyright © 2011 Delmar, Cengage Learning
  7. 7. Drugs Used in Treating Seborrhea <ul><li>Examples of topical antiseborrheics: </li></ul><ul><ul><ul><li>Sulfur: keratolytic, antipruritic, antibacterial, antifungal, and antiparasitic </li></ul></ul></ul><ul><ul><ul><li>Salicylic acid: keratolytic, antipruritic, and antibacterial </li></ul></ul></ul><ul><ul><ul><li>Coal tar: keratolytic and degreasing </li></ul></ul></ul><ul><ul><ul><li>Benzoyl peroxide: keratolytic, antipruritic, antibacterial, and degreasing </li></ul></ul></ul><ul><ul><ul><li>Selenium sulfide: keratolytic, degreasing, and antifungal </li></ul></ul></ul>Copyright © 2011 Delmar, Cengage Learning
  8. 8. Other Agents Used to Treat Skin Disorders <ul><li>Astringents are agents that constrict tissues </li></ul><ul><li>Antiseptics are substances that kill or inhibit the growth of microbes on living tissue </li></ul><ul><li>Soaks and dressings are substances applied to areas to draw out fluid or relieve itching </li></ul><ul><li>Caustics are substances that destroy tissue </li></ul><ul><li>Counterirritants are substances that produce irritation and inflammation in areas of chronic inflammation </li></ul><ul><li>See Table 17-2 in your textbook for examples of these agents </li></ul>Copyright © 2011 Delmar, Cengage Learning