Plasma Clearance
 
 
 
Plasma Clearance <ul><li>Is the volume of plasma that is completely cleared  of the substance by the kidneys per unit time...
<ul><li>Clearance rate of a substance (ml/min)  </li></ul><ul><li>=  U x V </li></ul><ul><li>P </li></ul><ul><li>Urine con...
 
 
<ul><li>=  U x V </li></ul><ul><li>P </li></ul><ul><li>5.85mg/ml x 1ml/min </li></ul><ul><li>0.01mg/ml </li></ul><ul><li>=...
 
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Urine formation Plasma clearance by Dr. Riffat

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Urine formation Plasma clearance by Dr. Riffat

  1. 1. Plasma Clearance
  2. 5. Plasma Clearance <ul><li>Is the volume of plasma that is completely cleared of the substance by the kidneys per unit time. </li></ul>
  3. 6. <ul><li>Clearance rate of a substance (ml/min) </li></ul><ul><li>= U x V </li></ul><ul><li>P </li></ul><ul><li>Urine conc. of the substance x Urine flow rate (ml/min) </li></ul><ul><li>__________________________________________________ </li></ul><ul><li>Plasma concentration of the substance per ml of plasma </li></ul>
  4. 9. <ul><li>= U x V </li></ul><ul><li>P </li></ul><ul><li>5.85mg/ml x 1ml/min </li></ul><ul><li>0.01mg/ml </li></ul><ul><li>= 585 ml/min </li></ul><ul><li>Extraction ratio for PAH is 90% </li></ul><ul><li>585ml/min/0.9 = 650ml/min </li></ul><ul><li>Total blood flow through kidneys= 650/(1- 0.45)= 1185 ml/min </li></ul>

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