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SMB 28112013 Otto Boerman - PRIME Radboudumc

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SMB 28112013 Otto Boerman - PRIME Radboudumc

  1. 1. Preclinical Imaging Centre Centrum voor preklinische imaging van het Radboud UMC Prof. dr. Otto C. Boerman Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
  2. 2. RTM: Radboud Translational Medicine Discovery Screening preclinical testing Clinical trials Radboud University Nijmegen Medical Centre, The Netherlands
  3. 3. RTM: Radboud Translational Medicine Discovery Screening preclinical testing Clinical trials Radboud University Nijmegen Medical Centre, The Netherlands
  4. 4. Radboudumc Technology Centres Alain van Gool Bioinformatics Flow cytometry Preclinical pharmacology Proteomics Metabolomics Glycomics Genetics Otto Boerman Preclinical Imaging Radboudumc Technology Centers Big Data Robotic operations Microscopy Clinical trials Cleanrooms Malaria lab Neuroscience unit Biobank
  5. 5. PRIME: Preclinical Imaging Centre microSPECT Radboud University Nijmegen Medical Centre, The Netherlands
  6. 6. From human imaging to small animal imaging
  7. 7. From human imaging to small animal imaging Mouse Human Uptake of 123I-IBF by D2 receptors Neurology Dopamine w/ 99mTc-TRODAT 99mTc-MIBI Cardiovascular Stress 99mTc-MIBI [99mTc] Minigastrin Oncology *functional imaging Renal Cell Carcinoma
  8. 8. Radboud University Nijmegen Medical Centre, The Netherlands
  9. 9. Radboud University Nijmegen Medical Centre, The Netherlands
  10. 10. Radboud University Nijmegen Medical Centre, The Netherlands
  11. 11. Radboud University Nijmegen Medical Centre, The Netherlands
  12. 12. Radboud University Nijmegen Medical Centre, The Netherlands
  13. 13. PRIME Preclinical Imaging Centre microSPECT PET imaging in PRIME Radboud University Nijmegen Medical Centre, The Netherlands
  14. 14. Annihilation Radboud University Nijmegen Medical Centre, The Netherlands
  15. 15. FDG-PET: imaging cancer Normal FDG-PET Metastasized Melanoma
  16. 16. FDG-PET: functional imaging Monitor response to treatment Pre treatment 4 weeks after start of treatment 24 weeks after start of treatment Pre treatment Dept. Nuclear Medicine, Radboud University Nijmegen Medical Centre
  17. 17. FDG-PET: functional imaging Monitor response to treatment Pre treatment 4 weeks after start of treatment 24 weeks after start of treatment Pre treatment 1 week after start of imatinib treatment Dept. Nuclear Medicine, Radboud University Nijmegen Medical Centre
  18. 18. FDG-PET: functional imaging Monitor response to treatment Pre treatment 4 weeks after start of treatment 24 weeks after start of treatment Pre treatment 1 week after start of imatinib treatment Dept. Nuclear Medicine, Radboud University Nijmegen Medical Centre
  19. 19. microPET/CT scanner Radboud University Nijmegen Medical Centre, The Netherlands
  20. 20. Monitor the therapeutic effect of a new anti-cancer drug - 1 day Radboud University Nijmegen Medical Center, The Netherlands
  21. 21. Monitor the therapeutic effect of a new anti-cancer drug - 1 day 1 day Radboud University Nijmegen Medical Center, The Netherlands
  22. 22. Monitor the therapeutic effect of a new anti-cancer drug - 1 day 1 day 3 days Radboud University Nijmegen Medical Center, The Netherlands
  23. 23. Monitor the therapeutic effect of a new anti-cancer drug - 1 day 1 day 3 days 7 days Radboud University Nijmegen Medical Center, The Netherlands
  24. 24. PRIME Preclinical Imaging Centre microSPECT SPECT imaging in PRIME Radboud University Nijmegen Medical Centre, The Netherlands
  25. 25. Small animal SPECT imaging Radboud University Nijmegen Medical Centre, The Netherlands
  26. 26. Radboud University Nijmegen Medical Centre, The Netherlands 26
  27. 27. microSPECT imaging Radboud University Nijmegen Medical Centre, The Netherlands
  28. 28. Imaging transplated islets of Langerhans Diabetes type 1: autoimmune destruction of insulin producing beta cells Islet transplantation is a promising treatment for patients with type1 diabetes AIM: Non-invasive in vivo determination of beta cell mass after islet transplantation. In-111-DTPA-Exendin islets Radboud University Nijmegen Medical Centre, The Netherlands
  29. 29. Imaging transplated islets of Langerhans Radboud University Nijmegen Medical Centre, The Netherlands
  30. 30. Imaging transplated islets of Langerhans 2D 3W In-111-Exendin 6W 8W 11W Radboud University Nijmegen Medical Centre, The Netherlands
  31. 31. PRIME Preclinical Imaging Centre microSPECT Intravital fluorescence imaging in PRIME Radboud University Nijmegen Medical Centre, The Netherlands
  32. 32. Multi-photon fluorescence microscopy Radboud University Nijmegen Medical Centre, The Netherlands
  33. 33. Multi-photon fluorescence microscopy Monitoring of tumor development using the dorsal skinfold chamber model Radboud University Nijmegen Medical Centre, The Netherlands
  34. 34. Multi-photon fluorescence microscopy Tumor cells Extracellular matrix, collagen, muscle fibers Fat cells, nerves Blood vessels, immune cells Radboud University Nijmegen Medical Centre, The Netherlands
  35. 35. Multi-photon fluorescence microscopy Tumor cells Extracellular matrix, collagen, muscle fibers Fat cells, nerves Blood vessels, immune cells Radboud University Nijmegen Medical Centre, The Netherlands
  36. 36. Immunofluorescence Guided Surgery Radboud University Nijmegen Medical Center, The Netherlands
  37. 37. Immunofluorescence Guided Surgery Radboud University Nijmegen Medical Center, The Netherlands
  38. 38. Multi-modality Imaging Fluorescence imaging MRI PET Multiphoton imaging Radboud University Nijmegen Medical Centre, The Netherlands
  39. 39. Drug development Research Hoffmann La Roche Novartis Sanofi Fuji Biotechnology Future Chemistry Immunomedics Inc. Synaffix Wilex Milabs Radboud University Nijmegen Medical Centre, The Netherlands

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