1. Visie op Valorisatie in de
Topsector Chemie
Floris Rutjes
Radboud University, Institute for Molecules and Materials
Opening Innovation Lab NTC
Nijmegen
April 17, 2014

2. Business opportunities: rowing
The Macon blade became
popular in the 1960s and
was the most widely used
blade type for thirty years.
Introduced in 1991, its
asymmetric design and
increased surface area
create a bigger "shovel".
The latest design offers the
greatest potential for
increasing boat speed.

3. Organic synthesis over the years
The Lavoisier lab (1770)
2-deoxy-D-ribose
KC Nicolaou, FPJT Rutjes, EA Theodorakis, J Tiebes, M
Sato, E Untersteller J Am Chem Soc 1995, 117, 1173.
Microreactor flow synthesis

4. Our design: Microreactor setup
GC / HPLC
Offline analysis
NMR / MS / Raman / IR
Online analysis
Collaboration with Prof. van Hest (Radboud University) and Fraunhofer IMS (Duisburg, Germany)

5. Conventional batch versus flow process
Conventional batch process
Continuous flow
microreactors
Continuous flow process Translation
Intrinsic benefits
– Safer reactions
– Faster reactions
– Cleaner products and process
– Easy scale‐up
Practical benefits
– Reproducible results
– Quick optimization
– Inline analysis possible
– On site (local) production

6. 6
Research prototypes
Patent application PCT/EP/2006/010299

7. From micro to production scale
Step 1: design of
new flow process
Step 2: automated
optimization
Step 3: synthesis
(multigram)
Step 4: Scale out
• Step 1: Design of a new flow process
• Step 2: Automated optimization and modeling of reaction data
• Step 3: Scale up to larger microreactor
• Step 4: Further scale out through numbering up microreactors

8. FutureChemistry
• New spin-off FutureChemistry was founded in 2008
• Investments by FhG and PPM Oost
• Former PhD-students – Kaspar Koch
and Pieter Nieuwland – became CEO and CTO
• First commercial equipment launched March 2009 gelanceerd
• Joint projects with academic groups were setup to develop new
technology
• www.futurechemistry.com

9. From research to commercial equipment
PCT/2006/010299/EP2086684

10. New opportunities: Quantum dot applications
QD Sector examples
Biomedical Electronics Optoelectronics
In Vivo imaging Transistors QDLED displays
Optics Energy Security
Laser Solar panels Tracing methods

11. New opportunities: PET tracer synthesis
DC
F
F
11:00
15:00
17:00
13:00
D
C
F
DC
Cyclotron
FlowSafe
Injection
PET‐scanner
PET‐image
1
2
3
4
5 15
2
3
4

12. Chemistry-related companies in Nijmegen
IMM
Institute for
Molecules
and
Materials
NCMLS
Nijmegen
Centre for
Molecular Life
Sciences
DI-BCB
Donders
Institute for
Brain,
Cognition and
Behavior
Nijmegen
Centre for
Clinical &
Translational
Medical
Research Radboud
Translational
Medicine
tf2 devices

13. Key success factors
• Basis of high quality, challenging – curiosity-driven – science
• Awareness of the societal and commercial potential of scientific
research and inventions
• Entrepreneurial researchers to develop these scientific inventions
into commercial products (the actual innovation)
• Attention to entrepreneurship in academic degree programs and
PhD-programs
– Create awareness among students in Bachelor- and Master-programs
– MSc- and PhD-students realize that it is a viable possibility to start their own
company
– Strong stimulus provided by peers - ‘zien ondernemen is doen ondernemen’
13

14. KplusV organisatieadvies, verschil zien verschil maken
De visie van het Topteam Chemie
werkgroep ‘Ondernemerschap en de Regio’

15. KplusV organisatieadvies, verschil zien verschil maken
De visie op nieuwe bedrijvigheid
?
+ =
faciliteiten
ondernemer(schap)
financiering
bedrijfsvoering

16. KplusV organisatieadvies, verschil zien verschil maken
Team Bert-Jan Lommerts & Arie Brouwer
// Makelen en schakelen netwerk topsector
// Ontsluiten financieringsmogelijkheden
// Ondersteuning bij bedrijfsvoering
Aandachtsvelden stuurgroep ‘O&R’
Team Floris Rutjes & Nelo Emerencia
// Thematisch ingestoken, fysieke locaties
voor jonge, innovatieve bedrijven
// Coördinatiefunctie: netwerk van locaties
www.topchemie.nl www.topsectorchemie.nl

17. KplusV organisatieadvies, verschil zien verschil maken
KIEM
START
ONTWIKKEL
GROEI
CONSOLIDATIE
innovatie proces
1
Positionering in het innovatie proces
100

18. KplusV organisatieadvies, verschil zien verschil maken
Onderscheid tussen iLAB en COCi-locatie
schrijven v/h
business plan
subsidie
overzicht
zuurkast
iLAB
advies over de
groeistrategie
training van het
ondernemerschap
contact met
financiers
Pilotschaal
COCi
inrichting van
personeelsbestand

19. KplusV organisatieadvies, verschil zien verschil maken
+
+
Operationeel
In ontwikkeling
Kennismaking
Stand van zaken: iLABs en COCi-locaties
Opening gepland

20. iLAB
COCi
iLAB (i.o.)
COCi (i.o.)
tandem
LEGENDA LOCATIES
iLABs
-Nijmegen
-Eindhoven
-Amsterdam
-Delft (ond. Biotech Campus)
-Zwolle (ond. Green PAC)
-Wageningen (per 10-4)
-Utrecht (i.o.)
-Groningen (i.o)
-Leiden (i.o)
-Enschede (i.o)
COCi-locaties
-Chemelot
-Plant One
-Green Chemistry Campus
-Delft (ond. Biotech Campus)
-Emmen (ond. Green PAC)

21. KplusV organisatieadvies, verschil zien verschil maken
Toekomst van iLABS en COCi locaties
• Sterk interactief netwerk van iLABS en COCi locaties, nauw verbonden met TopchemieΔ
• Regelmatige bijeenkomsten, uitwisseling ervaringen
• Nauwe samenwerking tussen specifieke iLABs en COCi’s
• Sterkere link naar HBO
• Aansluiting bij gevestigde industrieën
• Monitoren van activiteiten en voortgang op elke locatie om kwaliteit van het label te
waarborgen
• Sterkere links naar andere topsectoren, met name LSH, Agri/Food, HTSM en Energie
• Verduurzamen van iLAB/COCi netwerk als zelfstandig opererende valorisatiemotor