1. 21‐2‐2013
noviotech BV
bringing technologies to the market
Titel presentatie:
van Glucose Sensor tot Hydrogel
31 januari 2013
www.noviotech.com
Molenveldlaan 43
6523 RJ, Nijmegen
The Netherlands
Tel. +31 24 71 14 015
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Organisatie
Private onderneming, onafhankelijk
Opgericht in 2011 door Hanssen/Tweehuysen
Aandeelhouders:
Tweehuysen Holding BV
Hanssen Investment and Consultancy BV
Prof. dr. Ir. Jan C.M. van Hest (RU, Bio-organische chemie)
Prof. dr. Alan E. Rowan (RU, Moleculaire materialen)
Wetenschappelijk adviseurs:
Prof. dr. Jan van Hest,
Prof. dr. Alan Rowan en
Prof. dr. Roeland Nolte (oud directeur IMM, lid KNAW, leerstoel
macromoleculaire chemie, polymeer- en nanotechnologie)
Samenwerking met de Radboud Universiteit:
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Bron: website Radboud
Universiteit
“Samen met Noviotech,
commercieel partner van de
Radboud Universiteit en het
Radboud Universiteit Medisch
Centrum, worden
verschillende richtingen
onderzocht.”
Bron: NRC van
25 januari 2013,
wetenschapsbijlage
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4. 21‐2‐2013
Bron: de Gelderlander van 26
januari 2013:
“Samen met het bedrijf
NovioTech kijken de
scheikundigen hoe de stof in de
medische wereld kan worden
toegepast.”
Medewerkers NovioTech
BV/NovioSense BV
MSc Margo Groeneveld
MSc Hans Hanssen
MSc Jan Lauko
Dr. Hera Lichtenbeld
Dr. Marco Thio
Ir. R. Tweehuysen
MSc. Jeroen van der Velden
Dr. Chris Wilson
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Doel van de presentaties
Valorisatie van kennis:
Innovation gap, ‘Valley of Death’
valorisatie van kennis, kan dat beter ??
Daartoe aan de hand van concrete
voorbeelden:
Portfolio en werkwijze NovioTech BV a.d.h. van :
NovioSense glucose sensor
NovioHelix thermogel
Nanowipe
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6. 21‐2‐2013
NanoWipe
Contacts with Potential End Users (DSM Resolve) and
Instrument Manufacturers (NanoSight UK)
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Impressie van NovioTech als
Pijplijn, spin-off en nieuwe ontwikkelingen
Laagdrempelig voor onderzoekers met interesse in het
opzetten van een bedrijf, opdoen van ervaring
Breed netwerk met bedrijven in LS en maakindustrie
Open innovatie!
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9. Telemedicine
Telemedicine is not new:
Native Americans use smoke signals to warn of illness
People in Remote Areas use two-way radio to
communicate with doctors
Medicine at a Distance:
Consultation via e-mail, telephone or video conference
Real-time single point data and trend analysis
Dynamic and responsive healthcare regimen changes
14. Early disease detection and early disease management
Real-Time management of chronic conditions
Reduced Burden on Healthcare and Increased Quality of Life
16. Continuous Glucose Monitors
Finger Prick Glucose – Single Snapshot in Time
Continuous Montior – Follows Glucose Trends in Time
Alerts for oncoming highs and lows
Alerts during resting hours
Correlate effects of diet and exercise on glucose levels
CGM results in tighter glucose control, high patient
compliance and reduction in hospital visits
17. Market
Bottom line CGM use reduces costs to the insurer!
CGM Statistics Collected in the Netherlands1
Hospital admision reduced by upto 80%
Severe Hypoglycemia reduced by 85%
1. British Journal of Diabetes and Vascular Disease 2011, 11, 3, 145-149
26. About me
HLO RU
1994
now
Technician PhD NovioTech
biochemistry biology
Val
27. Mt. NovioHelix
the summit
deals
customers
team
market study
IP
ideas
28. thermoreversible
customizable mimics ECM
NovioHelix
biocompatible nanosized pores
4°C 37°C
optically
>99.95% water
transparent
“Take one kilogram of polyisocyanide polymer. Sprinkle liberally across an Olympic swimming
pool. Warm gently. Within minutes, your jelly is ready. Serves 25 million.” (A. Rowan, Radboud)
“I can’t think of another synthetic material that shows this specific behavior,” (D. Weitz, Harvard)
“the first semi‐flexible synthetic polymers to have tunable properties,” ( M. Gardel, Univ. of Chicago)
29. NovioHelix: ideas
Drug
Cell Culture Cosmetics Household Wound care
Delivery
and many many more...
30. NovioHelix: market
NovioHelix: IP
Radboud University
Drug
Cell Culture Cosmetics Household Wound care
Delivery excl. worldwide license
>$6B >$170B >$20B >$10B
NovioTech
market size
competitors
keyplayers
prospects
31. Mt. NovioHelix
deals
customers
team
market study
IP
ideas
39. Nanotechnology
What is it and why it matters...
Arranging
Atoms
Now:
Legoblocks
handled with
boxing gloves
Nanotech:
Take off boxing
gloves
- Confidential -
40. Market Segments & GR
All new products – didn’t exist 10 yrs
ago Fast growing market
Powders best penetrated now, other markets still need growth and follow later
- Confidential -
41. “Nano” Risk Management
New technology challenge is in the Potential Risks
Nanomaterial properties differ from bulk counterpart (potential
hazard)
Extreme small properties allow for easy absorption in humans
(exposure)
x =
Hazard Exposure Risk
- Confidential -
42. Focus on exposure: new tools required
detect
?
NanoWipe
x =
Hazard Exposure
- Confidential -
43. Nanowipe
Tunable thermosensitive hydrogel
Nanowipe prototype
developed & proof of
principle studies done
industry standard E2834-12 (ASTM standard for
nanoparticle analysis – similar to ISO standards)
- Confidential -
44. NanoWipe - competition
Competition comes from aerosol instruments & other wipes
<100% 100% (±10)
Sample Mean Variance
Recovery Recovery
Ghostwipe
(digest)
Ghostwipe
(non‐digest)
Kimtech
Precision Wipe
Lab Paper
UltraWipe ‐ ‐
NanoWipe ±
Competitive in house testing shows no comparable wipe on the market
Most wipes generate NPs rather than collect them
Recovery NPs from wipes is destructive for NPs in other wipes
- Confidential -
45. Hurdles to a market ready NanoWipe
What Potential hurdles
Tissue, holder, foil? Use of wipe, idiot
proof?
Packaging – foil, paper pouch, blisterpack None expected
Market ready product None expected
Field testing Number test clients
Product validation Batch consistency
Supply chain Delivery
- Confidential -
