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20150528 smb han bio centre

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20150528 smb han bio centre

  1. 1. HAN BioCentre Centre of Expertise in Biotechnology & Analysis Christien Lokman 28 May 2015
  2. 2. WHY?  For well educated students  For teachers who know the ‘state of the art’  For companies, to support in research and innovation
  3. 3. Industry and universities Research HAN BioCentre Education: Bachelor, Master, Courses BIODISCOVERY
  4. 4. DISCOVERY
  5. 5. Development of smart screeningssystems  antimicrobial/antifungal – Medical – Agro & Food – other  C. elegans screeningssystem – Medical (obesity) – Safety/Toxicity
  6. 6. Oil from yeast  In cooperation with Wageningen UR  Companies: Nuplex, van Wijhe, Latexfalt, Holland Colors, Parenco, Dyadic, MicCell, MVO
  7. 7. ANALYSIS
  8. 8. Biological screening systems Analytical chemistry Bio-informatics Molecular biology  PCR/qPCR  SDS-PAGE  LC-MS  HPLC  FPLC  GC  Fluorescence microscopy Amphotericin 0 20000 40000 60000 80000 100000 120000 0:00 0:37 1:15 1:53 2:30 3:08 3:46 4:23 5:01 5:39 6:17 6:54 7:32 8:10 8:47 9:25 10:03 10:40 11:18 11:56 12:33 13:11 13:49 14:26 15:04 15:42 time (h) Luminescens water NaPb DMSO 1:100 Amph 20 µM Amph 10 µM Amph 5 µM Amph 2,5 µM Amph 1 µM Amph 0,5 µM Amph 0,1 µM
  9. 9. PRODUCTION
  10. 10. Fermentation & downstream processing • From 1 to 20 L (E. coli, lactic acid bacteria, Bacillus, Helicobacter, filamentous fungi, basidiomycetes, yeast) • Downstream processing – IEX – GPC – Microfiltration – Ultrafiltration • Strain selection • Genetic modification of m.o.
  11. 11. APPLICATION
  12. 12. In collaboration with companies and universities  Food/Feed  Agro  Health  Sustainable energy
  13. 13. • AM-Pharma • Aquamar • Argos Oil • Avatar Biotechnologies (USA) • Avebe • Basidiofactory • Benilabs • B.O.B. • Cellution Biotech • C4C • Christian Hansen (DK) • CSK Food Enrichment • CU+TOP • Cyto-Barr • DMV International • DSM • Dyadic Nederland • European Veterinary Laboratory • Falco Diagnostics • Filtex • Innovative SeedTechnology • TNO Quality of Life • Koppert • LabTie • Meddens Diagnostics • MicCell • Micreos • Nsure • Nuplex • NVWA • NYtor • Parenco • Productschap Tuinbouw • ProteoNic • Quaker • Rainbow Sustainable solutions • RIVM • Shell • Uniqema/Croda • Unilever • Van Wijhe • Vitaleech Bioscience • Vivalt screening • Xenikos
  14. 14. Consortia  Centre of Biobased Economy  Green Health  IJ5-lab  others
  15. 15. What do we offer? - Contract research - Cooperative research • Basidiofactory • Vivalt screening - Lab facilities • Basidiofactory • Vivalt screening - Workshops APPLICATIONDISCOVERY ANALYSIS PRODUCTION
  16. 16. What do companies bring? - Knowledge/new developments - Guest lectures - Facility sharing - Internships APPLICATIONDISCOVERY ANALYSIS PRODUCTION
  17. 17. www.hanbiocentre.nl 28th of January 2016 Conference HAN BioCentre 10 years

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