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20141014 smb meet inn- genalice

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20141014 smb meet inn- genalice

  1. 1. NO INFINITE PROBABILITY DRIVE INSIDE UP TO 200X FASTER THAN CONVENTIONAL TOOLS Genalice B.V. the Netherlands confiden'al WE HAVE ALWAYS THOUGHT THERE WAS SOMETHING FUNDAMENTALLY WRONG WITH DNA MAPPING THE END OF THE BIG BAM THEORY GENALICE Building the “Google DNA” company ICT & MedTech: new business opportuni'es Jos Lunenberg Chief Business Officer
  2. 2. Today’s Journey ▲ the drive ▲ the opportunity ▲ the status ▲ the environment ▲ the route ▲ the hurdles confiden'al 2
  3. 3. THE DRIVE confiden'al 3
  4. 4. The drive One Size Does Not Fit All confiden'al 4
  5. 5. DNA 3.2 billion base pairs Organized in 23 chromosome pairs The cause confiden'al 5
  6. 6. The soluIon Targeted treatment based on molecular profiling is the solu'on PaIents with same condiIon DNA PaIents with same condiIon Profiling Good responders No responders Bad side effects confiden'al 6
  7. 7. The soluIon Personalized Medicine confiden'al 7
  8. 8. The soluIon Biomarkers and the diagnosIcs process confiden'al 8
  9. 9. THE OPPORTUNITY confiden'al 9
  10. 10. The vision At the brink of the BIGGEST change in medicine Enabled through advances in DNA digitaliza'on and by powerful data analysis Sequencing Adapted from “The Crea've Destruc'on of Medicine” by Eric Topol, MD confiden'al 10 Cell Phone Personal Computer Internet Digital Devices Social Networks The Great InflecIon of Medicine Accelera.on of Technology 1970 1980 1990 2000 2010 2020
  11. 11. The market developments Main sequencing methods & cost development 11 Company Method Sanger Ins'tute Sanger Roche 454 pyro Illumina Solexa Applied Biosystems (LT) SOLiD Life Technologies Ion Torrent semiconductor Complete Genomics DNA nanoball Helicos Biosciences Heliscope single molecule Pacific Biosciences Single molecule real 'me (SMRT) Oxford Nanopore Nanopore DNA Illumina’s introduction of the HiSeq X Ten
  12. 12. The momentum DNA data digitalizaIon is skyrockeIng Number of sequenced full human genomes is exploding Adapted from Technology Review, May/June 2012, ‘Bases to Bytes’ by Mike Orcutt confiden'al 12
  13. 13. Hans Karten (1961) 13 The wizkid Chief ExecuIve & Technology Officer ▲ BSc Electrical Engineering ▲ 14 years career at Oracle Corpora'on, patentee of 11 patents ▲ 7 years pro-­‐deo “Chairman of the Bap'st Church” in Harderwijk ▲ 3 year technical due-­‐diligences for a Venture Capitalist ▲ Co-­‐founder of GENALICE
  14. 14. The mission confiden'al 14
  15. 15. Data processing and analysis soluIon for sequencing speed increases confiden'al 15
  16. 16. 16 THE STATUS
  17. 17. DNA data processing & analysis workflow GENALICE product proposi'ons Individual NGS data analyses confiden'al 17 GENALICE MAP GENALICE LINK GENALICE CHECK The product porcolio Downstream analysis Clinical Decision Support Preprocessing Next GeneraIon Sequencing Correlation with other domains &
  18. 18. MAP in overview Next-­‐GeneraIon Sequencing data processing Preprocessing components Preprocessing Components Alignment Variant calling Annotation Description Mapping individual reads on right position Statistical correction of detected variants Variant qualification and association with existing knowledge confiden'al 18
  19. 19. IntergalacIc speed Up to 100x faster -­‐ from FASTQ to VCF in 30 minutes* using a small commodity hardware server with a dual Intel Xeon E5 processor *NGS data preprocessing for one full human genome (37x coverage) confiden'al 19
  20. 20. Storage reduction (fold change) Size magers Taking control of the NGS big data deluge Human Up to 100x smaller alignment output file 1000 genomes Cultivated tomato Wild tomato 100 75 50 25 0 100x 71x 15x ALIGNMENT OUTPUT PER HUMAN GENOME 400 GB 4 GB CONVENTIONAL TOOLS: GENALICE MAP: confiden'al 20
  21. 21. Scalable soluIon GENALICE MAP product proposiIon Delivered in an all-­‐in-­‐one appliance: the GENALICE VAULT Product components: ▲ MAP nodes (alignment & variant calling) ▲ CONTROL node (workflow management & real-­‐'me monitoring) ▲ GAR toolkit (incl. SAM/BAM/FASTQ converter and IGV viewer) Product features: ▲ Storage on board (incl. SSDs) ▲ Embedded Oracle database ▲ Graphical User Interface ▲ High level security XS S M L XL 2 4 * HGE37 = Human Genome Equivalents with an average of 37x coverage sequenced # Each MAP server only contains a dual standard INTEL XEON Processor E5-2620 confiden'al 21 Storage Maximum number of HGE37* 500 1,000 2,500 4,000 10,000 Performance align & call HGE37/day average 48 144 240 336 624 minutes to align & call a HGE37 average 30 10 6 4 2 Average total realignment days for fully loaded appliance 10 7 10 12 16
  22. 22. THE ENVIRONMENT confiden'al 22
  23. 23. Market Environment CompeIIve environment MAP A crowded & scagered market space… ▲ Descrip'on: Processing of raw NGS data in prepara'on of analysis Software Hardware ▲ Solware suites included in NGS machines by its FPGA accelerated confiden'al 23 Complementary vendors Open Source ▲ Open source tools Commercial ▲ Commercial specific hardware soluIons ▲ Solware soluIons/suites ▲ Consultancy services ▲ Turnkey appliances Cloud enabled ▲ Cloud services ▲ Cloud placorm
  24. 24. Market Environment CompeIIve environment MAP …with many players Software Hardware FPGA accelerated confiden'al 24 Complementary Open Source Commercial Cloud enabled BowTie2, BWA
  25. 25. CompeIIve environment MAP …but also one with significant room for improvement Speed confiden'al 25 Accuracy Format (C/E) Market Environment
  26. 26. THE ROUTE 26
  27. 27. THE PLAN Business Strategy ▲ Key / Social Opinion Leader management ▲ Focus on high volume centers/ini'a'ves ▲ Focus high complexity data opportuni'es ▲ Disrup've market penetra'on (costly) ▲ Partnerships with global top ins'tutes ▲ Partnerships with key market players (e.g. Intel, Illumina) confiden'al 27
  28. 28. Global Launch 42andMoore – seong new unofficial WR confiden'al 28
  29. 29. THE HURDLES confiden'al 29
  30. 30. THE HURDLES confiden'al 30 ▲ Team
  31. 31. The team confiden'al 31
  32. 32. THE HURDLES confiden'al 32 ▲ Team ▲ Money
  33. 33. THE HURDLES confiden'al 33 ▲ Team ▲ Money ▲ Market dynamics
  34. 34. 34 The market
  35. 35. THE HURDLES confiden'al 35 ▲ Team ▲ Money ▲ Market dynamics ▲ Support
  36. 36. Excellent team and network Our board of directors confiden'al 36 Former posiIons: CEO of Crucell (sold to J&J for 2.4B) Board member Galapagos (listed AMEX) Professor of entrepreneurship at IESE Business School in Barcelona Former posiIons: Group Management Royal Philips Chairman of the Board at Crucell Serial Enterpreneur Former posiIons: Founder and Managing Director Tango and RouteMobiel
  37. 37. Excellent team and network Our scien'fic advisory board Prof. Edwin Cuppen UMC Utrecht Head of Research Medical Gene'cs confiden'al 37 Amsterdam Prof. Gerrit Meijer VUmc Amsterdam Principal Inves'gator TraIT (CTMM)
  38. 38. THE HURDLES confiden'al 38 ▲ Team ▲ Money ▲ Market dynamics ▲ Support ▲ Credibility
  39. 39. Credibility ▲ Live up to claims & promises ▲ KOL support ▲ Give opportunity to test drive ▲ Push new format confiden'al 39
  40. 40. Low cost High speed High quality
  41. 41. the company confiden'al 41

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