Publication of presentation by Mani Diba MSc of Radboudumc, The Netherlands on Nanoparticles as building blocks for development of self-healing materials for regenerative medicine. Innoboot 2017, Nijmegen, The Netherlands on April 11, 2017.
170411 nanoparticles as building blocks for development of self healing materials for regenerative medicine (mani diba), innoboot 2017
Nanoparticles as Building Blocks for
Development of Self-Healing Materials
for Regenerative Medicine.
Department of Biomaterials
Radboud University Medical Center
11th April 2017
Regenerative medicine is a multidisciplinary field which
aims to repair or replace lost or damaged body parts.
Three main components:
Ideal Biomaterial for Regenerative Medicine
But how to apply this “ideal” biomaterial???
How to apply a biomaterial?
When a material is extruded/injected, it experiences extensive shear forces
Yielding and loss of mechanical integrity
Injection is the essential/preferred method in various applications including:
Minimally Invasive Treatments
Materials that can heal themselves after damage
How can we make
a self-healing biomaterial?
Biomaterials for Regenerative Medicine
Advantages of Bottom-up
Precise control over building blocks
Substantial control over bulk properties
Building blocks as carrier for multiple
drugs and/or growth factors
Special properties, e.g. self-healing
to self-healing biomaterials
(A bottom-up strategy)
Nanoparticles as building blocks
of colloidal (particle-based) gels:
(e.g. bioactive glasses and ceramics)
• Functionalization or loading with
Self-healing in colloidal gels
Reversible self-assembly of nanoparticles
91Wang et al., Biomaterials, 33, 2012, 8695-8703.
Micro vs. Nano
To develop composite hydrogels with high elasticity and self-healing
Average Diameter ≈ 400nm (swollen) Average Diameter ≈ 80nm
M. Diba, et al., Advanced Materials 2017, 1604672.
Controlling interactions between the nanoparticles:
Gel formation process
In vivo evaluation in osteoporotic rats
1 mm 1 mm 1 mm
Empty defect Filled with gel
Filled with gel+
12 weeks 8 weeks 8 weeks
(1) (2) (3) (4)
Femoral condyle defects
Nanoparticles are versatile building blocks for
development of multifunctional biomaterials.
Such biomaterials can be designed to:
• Self-heal after mechanical damage
• Stimulate bone regeneration
• Locally deliver therapeutic drugs
Development of gels with more bioceramic content and higher
Large-scale production of the nanoparticles and gels through
• Rousselot (world's leading producer of gelatin)
• CAM Bioceramics (producer of bioceramic particles)
• Smartodont (producer of bio-glass particles)
We are open for collaboration
with new business partners
Dr. Sander Leeuwenburgh
Prof. John Jansen
Dr. Jeroen van den Beucken
Winston Camargo, DDS
Prof. David Weitz
Prof. Huanan Wang
Dr. Tom Kodger
Dr. Shima Parsa
IOP Self-Healing Materials
Thanks for your attention
Email : Mani.Diba@Radboudumc.nl