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170411 nanoparticles as building blocks for development of self healing materials for regenerative medicine (mani diba), innoboot 2017

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Publication of presentation by Mani Diba MSc of Radboudumc, The Netherlands on Nanoparticles as building blocks for development of self-healing materials for regenerative medicine. Innoboot 2017, Nijmegen, The Netherlands on April 11, 2017.

170411 nanoparticles as building blocks for development of self healing materials for regenerative medicine (mani diba), innoboot 2017

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Nanoparticles as Building Blocks for
Development of Self-Healing Materials
for Regenerative Medicine.
Mani Diba
Department of Biomaterials
Radboud University Medical Center
11th April 2017
2
Regenerative Medicine
Regenerative medicine is a multidisciplinary field which
aims to repair or replace lost or damaged body parts.
Three main components:
• Biomaterials
• Cells
• Biomolecules
3
Ideal Biomaterial for Regenerative Medicine
But how to apply this “ideal” biomaterial???
How to apply a biomaterial?
4
Problem:
When a material is extruded/injected, it experiences extensive shear forces
Yielding and loss of mechanical integrity
Solution:
Self-healing biomaterials
 Injection is the essential/preferred method in various applications including:
3D Printing
Minimally Invasive Treatments
Self-Healing Materials
5
 Materials that can heal themselves after damage
How can we make
a self-healing biomaterial?
Biomaterials for Regenerative Medicine
6
Strategies:
Advantages of Bottom-up
Precise control over building blocks
Substantial control over bulk properties
Building blocks as carrier for multiple
drugs and/or growth factors
Special properties, e.g. self-healing

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170411 nanoparticles as building blocks for development of self healing materials for regenerative medicine (mani diba), innoboot 2017