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170411 nanoparticles as building blocks for development of self healing materials for regenerative medicine (mani diba), innoboot 2017

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Publication of presentation by Mani Diba MSc of Radboudumc, The Netherlands on Nanoparticles as building blocks for development of self-healing materials for regenerative medicine. Innoboot 2017, Nijmegen, The Netherlands on April 11, 2017.

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170411 nanoparticles as building blocks for development of self healing materials for regenerative medicine (mani diba), innoboot 2017

  1. 1. Nanoparticles as Building Blocks for Development of Self-Healing Materials for Regenerative Medicine. Mani Diba Department of Biomaterials Radboud University Medical Center 11th April 2017
  2. 2. 2 Regenerative Medicine Regenerative medicine is a multidisciplinary field which aims to repair or replace lost or damaged body parts. Three main components: • Biomaterials • Cells • Biomolecules
  3. 3. 3 Ideal Biomaterial for Regenerative Medicine But how to apply this “ideal” biomaterial???
  4. 4. How to apply a biomaterial? 4 Problem: When a material is extruded/injected, it experiences extensive shear forces Yielding and loss of mechanical integrity Solution: Self-healing biomaterials  Injection is the essential/preferred method in various applications including: 3D Printing Minimally Invasive Treatments
  5. 5. Self-Healing Materials 5  Materials that can heal themselves after damage How can we make a self-healing biomaterial?
  6. 6. Biomaterials for Regenerative Medicine 6 Strategies: Advantages of Bottom-up Precise control over building blocks Substantial control over bulk properties Building blocks as carrier for multiple drugs and/or growth factors Special properties, e.g. self-healing
  7. 7. Water Our Approach to self-healing biomaterials (A bottom-up strategy) 7  Nanoparticles as building blocks of colloidal (particle-based) gels: • Organic (e.g. gelatin) • Inorganic (e.g. bioactive glasses and ceramics) • Functionalization or loading with biomolecules/drugs
  8. 8. Self-healing in colloidal gels 8 Reversible self-assembly of nanoparticles Reversible bonds __ +
  9. 9. Why nanoparticles? 91Wang et al., Biomaterials, 33, 2012, 8695-8703. Micro vs. Nano Size matters!
  10. 10. Aim  To develop composite hydrogels with high elasticity and self-healing 10 Average Diameter ≈ 400nm (swollen) Average Diameter ≈ 80nm M. Diba, et al., Advanced Materials 2017, 1604672.
  11. 11. 11 Controlling interactions between the nanoparticles: GelatinSilica Repulsion Initial condition _ Attraction _ + Final condition
  12. 12. 12 Gel formation process Confocalfluorescent microscopy pHmeasurement Rheology measurement G' G" 250x Gel formation
  13. 13. 13 InjectableMoldable HighlyElastic
  14. 14. 14 R = Silica/gelatin particles mixing ratio φ = Particle volume fraction Self-healing after injection
  15. 15. 15 Tensile testCompression test
  16. 16. 16 In vivo evaluation in osteoporotic rats 1 mm 1 mm 1 mm Empty defect Filled with gel Filled with gel+ Anti-osteoporotic drug 12 weeks 8 weeks 8 weeks (1) (2) (3) (4) Femoral condyle defects
  17. 17. Conclusions 17 Nanoparticles are versatile building blocks for development of multifunctional biomaterials. Such biomaterials can be designed to: • Self-heal after mechanical damage • Stimulate bone regeneration • Locally deliver therapeutic drugs
  18. 18. Next steps…. 18  Development of gels with more bioceramic content and higher bioactivity  Large-scale production of the nanoparticles and gels through cooperation with: • Rousselot (world's leading producer of gelatin) • CAM Bioceramics (producer of bioceramic particles) • Smartodont (producer of bio-glass particles) We are open for collaboration with new business partners
  19. 19. Acknowledgments 19 Dr. Sander Leeuwenburgh Prof. John Jansen Dr. Jeroen van den Beucken Winston Camargo, DDS Prof. David Weitz Prof. Huanan Wang Dr. Tom Kodger Dr. Shima Parsa IOP Self-Healing Materials Funding:
  20. 20. Thanks for your attention Email : Mani.Diba@Radboudumc.nl

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