Which one is
vulnerable, A or B?
The one with
Morphology vs. Activity Imaging
IVUS OCT MRI
immunoscintigraphy, MRI with
targeted contrast media…
We Need Both
- by MRI
- by CT
Both are available today!
- by MRI
Pioneered in 1980s
Rummeny E, Weissleder R, Stark DD, Elizondo G, Ferrucci JT.
Radiologe. 1988 Aug;28(8):380-6.
Iron OxideIron Oxide
lBlood pool Magnetic resonance (MR)
imaging contrast media with a central
core of iron oxide generally coated by a
Shortening MR relaxation time
Engulfed by and accumulated in cells
with phagocytic activity
USPIOs Enter the AtheroscleroticUSPIOs Enter the Atherosclerotic
Plaque ThroughPlaque Through
lMacrophages that engulfed
lFissured or thin cap
l Extensive angiogenesis
l vasa vasorum leakage
l Intra plaque hemorrhage
In-vitro Study of Macrophage
In a series of in-vitro studies we have tested
the rate of SPIO uptake by human activated
monocytes in different conditions regarding
incubation time and concentration of SPIO.
All SPIO were labeled by a fluorescent dye