Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.
Plaque Characterization
with OCT
LightLab OCT
Optical Coherence
Tomography (OCT) is a new
class of ultra high-resolution
imaging technology using
near infr...
 Real time Imaging (to 30fps)
 Portable & Modular Design
 Digital System Architecture
LightLab Imaging PlatformLightLab...
Precision Imaging
Intimal ThickeningIntimal Thickening
Human Cadaver, Left Diagonal Branch
Intima
Media
Adventitia
Precision Imaging
Ex-vivo LAD
Thin capped FibroatheromaThin capped Fibroatheroma
Lesion
Cap < 60µm
(Renu Virmani, MD, AFIP)
NC
Ca++
FC
NC
F
C
Ca++ NC necrotic core
calcium
lumen
Precision Imaging
(Renu Virmani, MD, AFIP)
FC fibrous cap
Over sampling enables detailedOver sampling enables detailed
interrogationinterrogation
Ex-vivo LAD, LightLab .014” ImageW...
Precision Imaging
OCT Cine Pullback
Human Cadaver Circumflex Artery
Thin Capped LesionsThin Capped Lesions
Precision Imaging
Pull-back in stentPull-back in stent (note early side branch)(note early side branch)
In-vivo HumanIn-vi...
Precision Imaging
In-vivo Human Lesion 400 micrometer capIn-vivo Human Lesion 400 micrometer cap
.014” ImageWire
Prof. Ebe...
Bringing a microscope into theBringing a microscope into the
coronaries improves the clinicians abilitycoronaries improves...
Imaging BalloonImaging Balloon
In-vivo pig, LightLab Imaging Balloon, 3mm
and .014” ImageWire – No Flush
Brigham&Women’s H...
Stent and ThrombiStent and Thrombi
Full Screen
In-vivo pig, LightLab .014” ImageWire
Dr. Campbell Rogers, Brigham&Women’s ...
In-vivo Human Stent in StentIn-vivo Human Stent in Stent
.014” ImageWire
Prof. Eberhard Grube, Siegburg Heart Center
Preci...
 Upgrades
• Polarization Imaging
• Spectroscopic Imaging
• Doppler
• Elastography
LightLab Imaging Platform – FutureLight...
Polarization
Information for a better understanding ofInformation for a better understanding of
microanatomic plaque chara...
Different tissues exhibit differentDifferent tissues exhibit different
polarization effectspolarization effects
OCT
is inh...
Grayscale Polarization Difference
Table
Surface
Laminated
Structure
LightLab OCT Technology
(Birefringent)
(Non-Birefringe...
Magnitude
Polarization
Combined
Grey scale and polarization information may beGrey scale and polarization information may ...
Polarization
Evaluate plaque
structure and
orderliness
Grey Scale
Detailed
Morphological
understanding
Cap thickness, iden...
Lipid imaging in phantom
Spectroscopic image
Lipid+calcium Protein+calcium
Gray-scale image
Lipid+calcium Protein+calcium
...
Today’sToday’s
State-of-the-artState-of-the-art
OpticalOptical
CoherenceCoherence
TomographyTomography
100µm
In vivo 1µm O...
Changing the way
you see things.
Upcoming SlideShare
Loading in …5
×

Plaque characterization with oct

118 views

Published on

SHAPE Society

Published in: Health & Medicine
  • Be the first to comment

  • Be the first to like this

Plaque characterization with oct

  1. 1. Plaque Characterization with OCT
  2. 2. LightLab OCT Optical Coherence Tomography (OCT) is a new class of ultra high-resolution imaging technology using near infrared light. In addition to morphological imaging, LightLab OCT is capable of:  Spectroscopic Imaging  Polarization Imaging  Doppler  Elastography
  3. 3.  Real time Imaging (to 30fps)  Portable & Modular Design  Digital System Architecture LightLab Imaging PlatformLightLab Imaging Platform (Pending 510(k) Clearance) LightLab OCT  .006” micro-optic core  Microscopic resolution (12 µm)  .014” ImageWire & Balloon Imaging System Catheters
  4. 4. Precision Imaging Intimal ThickeningIntimal Thickening Human Cadaver, Left Diagonal Branch Intima Media Adventitia
  5. 5. Precision Imaging Ex-vivo LAD Thin capped FibroatheromaThin capped Fibroatheroma Lesion Cap < 60µm (Renu Virmani, MD, AFIP)
  6. 6. NC Ca++ FC NC F C Ca++ NC necrotic core calcium lumen Precision Imaging (Renu Virmani, MD, AFIP) FC fibrous cap
  7. 7. Over sampling enables detailedOver sampling enables detailed interrogationinterrogation Ex-vivo LAD, LightLab .014” ImageWire(Renu Virmani, MD, AFIP) Precision Imaging Core Thrombus Core
  8. 8. Precision Imaging OCT Cine Pullback Human Cadaver Circumflex Artery Thin Capped LesionsThin Capped Lesions
  9. 9. Precision Imaging Pull-back in stentPull-back in stent (note early side branch)(note early side branch) In-vivo HumanIn-vivo Human .014” ImageWire Prof. Eberhard Grube, Siegburg Heart Center
  10. 10. Precision Imaging In-vivo Human Lesion 400 micrometer capIn-vivo Human Lesion 400 micrometer cap .014” ImageWire Prof. Eberhard Grube, Siegburg Heart Center
  11. 11. Bringing a microscope into theBringing a microscope into the coronaries improves the clinicians abilitycoronaries improves the clinicians ability to:to:  Select the appropriate therapy  Titrate the delivery of specific therapies  Direct the delivery to targeted lesions  Develop entire new therapeutic approaches Precision Therapy
  12. 12. Imaging BalloonImaging Balloon In-vivo pig, LightLab Imaging Balloon, 3mm and .014” ImageWire – No Flush Brigham&Women’s Hospital ECI Lab Real-time inflation visualization Precision Therapy
  13. 13. Stent and ThrombiStent and Thrombi Full Screen In-vivo pig, LightLab .014” ImageWire Dr. Campbell Rogers, Brigham&Women’s Hospital ECI Lab Precision Therapy Zoom
  14. 14. In-vivo Human Stent in StentIn-vivo Human Stent in Stent .014” ImageWire Prof. Eberhard Grube, Siegburg Heart Center Precision Therapy
  15. 15.  Upgrades • Polarization Imaging • Spectroscopic Imaging • Doppler • Elastography LightLab Imaging Platform – FutureLightLab Imaging Platform – Future (Pending 510(k) Clearance) LightLab OCT Technology  Sub selective flush  Forward looking lens designs  Integrated therapeutic catheters Imaging System Catheters
  16. 16. Polarization Information for a better understanding ofInformation for a better understanding of microanatomic plaque characteristicsmicroanatomic plaque characteristics Evaluate plaque structure and orderliness Grey Scale Detailed Morphological understanding Cap thickness, identify fissures, calcium, lipid Cap/plaque Fiber Spectroscopy Determine chemical content of visualized lesions Lipid concentration Polarization LightLab OCT Technology
  17. 17. Different tissues exhibit differentDifferent tissues exhibit different polarization effectspolarization effects OCT is inherently sensitive to changes in the polarization of the probe beam. Birefringence is the major source of contrast in polarization- sensitive OCT imaging. Very High Very low Media (healthy) Cholesterol crystals Soft (lipid) plaque Fibrotic plaque Intima (healthy) Calcified plaque Structure Birefringence LightLab OCT Technology
  18. 18. Grayscale Polarization Difference Table Surface Laminated Structure LightLab OCT Technology (Birefringent) (Non-Birefringent) Polarization helps differentiate organizedPolarization helps differentiate organized (linear) from disorganized structures(linear) from disorganized structures
  19. 19. Magnitude Polarization Combined Grey scale and polarization information may beGrey scale and polarization information may be combined to localize and identify tissuecombined to localize and identify tissue characteristicscharacteristics Platform FuturesPlatform Futures
  20. 20. Polarization Evaluate plaque structure and orderliness Grey Scale Detailed Morphological understanding Cap thickness, identify fissures, calcium, lipid Cap/plaque Fiber Spectroscopy Determine chemical content of visualized lesions Lipid concentration Polarization LightLab OCT Technology Information for a better understanding ofInformation for a better understanding of microanatomic plaque characteristicsmicroanatomic plaque characteristics
  21. 21. Lipid imaging in phantom Spectroscopic image Lipid+calcium Protein+calcium Gray-scale image Lipid+calcium Protein+calcium OCT Spectroscopy identifies differences in composition LightLab OCT Technology
  22. 22. Today’sToday’s State-of-the-artState-of-the-art OpticalOptical CoherenceCoherence TomographyTomography 100µm In vivo 1µm OCT (Image Courtesy of J. Fujimoto, MIT) The Future of OCT Imaging
  23. 23. Changing the way you see things.

×