Periadventitial fat surrounding arteries may play an important role in plaque inflammation. Researchers introduced macrophage-like activity in the periadventitial fat of aortas in Apo E deficient mice. This suggests that adipocytes in periadventitial fat surrounding arteries can exhibit macrophage-like behavior that may contribute to plaque inflammation.

1. PERIADVENTITIAL FAT MAY PLAY AN IMPORTANT ROLE IN PLAQUE INFLAMMATION;
INTRODUCING MACROPHAGE-LIKE ACTIVITY OF ADIPOCYTES IN PERIADVENTITIAL FAT OF APO E DEFICIENT MICE AORTA
Silvio Litovsky, MD, Mohammad Madjid, MD, Ward Casscells, MD, James T. Willerson, MD, Morteza Naghavi, MD
Center for Vulnerable Plaque Research
Texas Heart Institute & University of Texas at Houston
Texas Heart Institute®