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© 2002 Slide 1
Trans-Blood Vision™ Possibilities
for Vulnerable Plaque
A Presentation for the
3rd
Annual
Vulnerable Plaque...
© 2002 Slide 2
Seeing Through Blood
The technique is adapted from military methods to see through
smoke, mist, fog, etc.
S...
© 2002 Slide 3
System Illustration
Monitor – already in place
CardioOptics IR Instrument:
- IR illumination source
- IR vi...
© 2002 Slide 4
• Looking directly through flowing
blood in a live animal
• Clip begins with exploration of
bifurcation in ...
© 2002 Slide 5
Video Clip of Vein Bifurcation
Unprocessed proof of concept video taken through flowing blood.
© 2002 Slide 6
Comments
• Structures appear as if viewed through water
• High degree of reflectivity from tissue surfaces
...
© 2002 Slide 7
Augmentative Technologies
o Dimensional measurement: The ability to quantitatively
measure the size of stru...
© 2002 Slide 8
Vulnerable Plaque Potential
 Find lesions without first entering them (forward view)
 Determine size & su...
© 2002 Slide 9
Conclusion:
Trans-Blood Vision™ has sufficient potential to
provide a platform for real-time, simultaneous,...
© 2002 Slide 9
Conclusion:
Trans-Blood Vision™ has sufficient potential to
provide a platform for real-time, simultaneous,...
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Optic

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Optic

  1. 1. © 2002 Slide 1 Trans-Blood Vision™ Possibilities for Vulnerable Plaque A Presentation for the 3rd Annual Vulnerable Plaque Symposium March 16, 2002
  2. 2. © 2002 Slide 2 Seeing Through Blood The technique is adapted from military methods to see through smoke, mist, fog, etc. SWIR WavelengthVisible Wavelengths For example, the following satellite photos of a section of the Oahu coastline illustrate how mist and haze seen at visible wavelengths disappear when viewed in the Short Wave IR band. Trans-Blood Vision™ is a patented infrared technique to see directly through blood.
  3. 3. © 2002 Slide 3 System Illustration Monitor – already in place CardioOptics IR Instrument: - IR illumination source - IR video camera IR interconnect cable Sterile, disposable IR fiberoptic catheter:
  4. 4. © 2002 Slide 4 • Looking directly through flowing blood in a live animal • Clip begins with exploration of bifurcation in the portal vein system & ends with canulation of selected branch • Raw, unprocessed video. Black & white presentation. Video Clip: Endocardial Imaging of IVC-Portal Vein System 1 2 To Heart (Inferior Vena Cava) Portal Vein System Caudal Vein
  5. 5. © 2002 Slide 5 Video Clip of Vein Bifurcation Unprocessed proof of concept video taken through flowing blood.
  6. 6. © 2002 Slide 6 Comments • Structures appear as if viewed through water • High degree of reflectivity from tissue surfaces • No video enhancement techniques have yet been applied, which will dramatically improve images.
  7. 7. © 2002 Slide 7 Augmentative Technologies o Dimensional measurement: The ability to quantitatively measure the size of structures visualized. This includes granularity and surface feature detail assessment. o Tissue/material characterization: The ability to provide the clinician with information about the nature of the structure in the TBV™ view (e.g., detection of calcification, presence of lipids). o Real-time motion analysis: The ability to perform real-time dynamic elastic properties assessment. o Membrane penetration: The ability to determine tissue/material characterization below the surface of membranes associated with Vulnerable Plaque lesions. Note: The following are extensions of Trans-Blood Vision ™. They have been theorized, tested to some degree in vitro, but not yet tested in vivo or on Vulnerable Plaque lesions.
  8. 8. © 2002 Slide 8 Vulnerable Plaque Potential  Find lesions without first entering them (forward view)  Determine size & surface characteristics in high resolution  Look at material constituents, both on and below the surface (within limited IR wavelengths)  Perform dynamic elastic velocity profiles in real time But not:  Provide direct visual guidance for therapy  Penetrate deeply like ultrasound Combining Trans-Blood Vision™ with these promising augmentative technologies provides the potential to simultaneously in real-time:  Measure lesion temperature (though a temperature probe could be visually guided)
  9. 9. © 2002 Slide 9 Conclusion: Trans-Blood Vision™ has sufficient potential to provide a platform for real-time, simultaneous, multi-mode Vulnerable Plaque lesion detection, analysis, and therapy guidance that it warrants significant investigation, possibly in combination with other technologies currently under development.
  10. 10. © 2002 Slide 9 Conclusion: Trans-Blood Vision™ has sufficient potential to provide a platform for real-time, simultaneous, multi-mode Vulnerable Plaque lesion detection, analysis, and therapy guidance that it warrants significant investigation, possibly in combination with other technologies currently under development.

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