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Biodistribution of spio in apo e deficient mice

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Biodistribution of spio in apo e deficient mice

  1. 1. Biodistribution ofBiodistribution of SPIO in ApoESPIO in ApoE Deficient MiceDeficient Mice CNS-1-1d is MION madeCNS-1-1d is MION made by Dr. Chanby Dr. Chan
  2. 2. 3 apoE deficint Mice 1mMol/kg SPIO injected intravenously Sacrifice 2 hours, one day & two days after injection Staining of samples from aorta, heart, liver, lung, Spleen and kidney with Perl’s, H&E, CD68
  3. 3. 1 Day After Injection,1 Day After Injection, Aortic RootAortic Root H&E
  4. 4. 1 Day After Injection,1 Day After Injection, Aortic RootAortic Root Perl’s
  5. 5. 1 Day After Injection,1 Day After Injection, Aortic RootAortic Root
  6. 6. 1 Day After Injection,1 Day After Injection, Ascending AortaAscending Aorta
  7. 7. 1 Day After Injection,1 Day After Injection, Ascending AortaAscending Aorta
  8. 8. Day3Day3 Aortic RootAortic Root
  9. 9. LiverLiver Day2 Day3
  10. 10. Day3Day3 Descending aorta, H&EDescending aorta, H&E
  11. 11. Day3Day3 Descending aorta, no plaque no IronDescending aorta, no plaque no Iron
  12. 12.  We have different kinds of SPIO particles that weWe have different kinds of SPIO particles that we are going to compare and see which one hasare going to compare and see which one has optimal characteristics of macrophage uptake.optimal characteristics of macrophage uptake.  We are doing macrophage uptake studies and ourWe are doing macrophage uptake studies and our preliminary results show that these particles arepreliminary results show that these particles are taken up by macrophagetaken up by macrophage

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