Learning Set 4: Lesson 1

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Learning Set 4: Lesson 1

  1. 1. Sudden Death and Sickle Cell Trait: HowKnowing Your Genes Can Save Your Life Dale Lloyd II, No. 39. (The Rice Football Webletter) 2006 After running 16 consecutive sprints of 100 yards each, he collapsed. He died the next day from acute exertional rhabdomyolysis (ER) associated with a genetic condition called sickle cell trait. Learning Set 4 : Lesson 1 : Slide 1
  2. 2. Blood CellsNormal Blood Sickle Cell Trait Sickle Cell Disease Cells Blood Cells Blood Cells Learning Set 4 : Lesson 1 : Slide 2
  3. 3. Sickle Cell Disease• Interview with sickle cell patient: pain• View Video on sickle cell anemia• View video on sickle cell trait Learning Set 4 : Lesson 1 : Slide 3
  4. 4. Hemoglobin Hemoglobin subunitRed Blood Cell Oxygen molecule o o Learning Set 4 : Lesson 1 : Slide 4
  5. 5. Hemoglobin (transport protein) oxygen molecule (O2) Hemoglobin subunitRed Blood Cell Learning Set 4 : Lesson 1 : Slide 5
  6. 6. Hemoglobin Learning Set 4 : Lesson 1 6Slide 6 :
  7. 7. Hemoglobin Learning Set 4 : Lesson 1 7Slide 6 :
  8. 8. Hemoglobin Learning Set 4 : Lesson 1 8Slide 6 :
  9. 9. Hemoglobin Learning Set 4 : Lesson 1 9Slide 6 :
  10. 10. Hemoglobin Learning Set 4 : Lesson 1 10 : Slide 6
  11. 11. Hemoglobin Learning Set 4 : Lesson 1 11 : Slide 6
  12. 12. Hemoglobin Learning Set 4 : Lesson 1 12 : Slide 6
  13. 13. Hemoglobin Learning Set 4 : Lesson 1 13 : Slide 6
  14. 14. Hemoglobin Learning Set 4 : Lesson 1 14 : Slide 6
  15. 15. Electrophoresis of Sickling and Non Sickling Hemoglobin Learning Set 4 : Lesson 2 : Slide 7
  16. 16. Electrophoresis of Sickling and Non Sickling Hemoglobin Learning Set 4 : Lesson 2 : Slide 8
  17. 17. Chromosomal Location of Hemoglobin Chromosome 11 Learning Set 4 : Lesson 2 : Slide 9
  18. 18. Mutation found in Hemoglobin Learning Set 4 : Lesson 2 : Slide 10
  19. 19. Mutation found in Hemoglobin Learning Set 4 : Lesson 2 : Slide 11
  20. 20. “Rules” that amino acids follow• Charge – Positive and negative charged amino Red = positive charge (+) acids attract each other K, R, H – Amino acids with the same kind of charge repel each other Yellow = negative charge• Hydrophobicity (-) – Hydrophilic amino acids attract water – Hydrophobic amino acids repel water and D, E hydrophilic amino acids Green = hydrophobic – Hydrophobic amino acids attract other hydrophobic amino acids. A, V, L, I, P, M, F, W• Cysteines Blue = hydrophilic – Cysteines are a type of amino acid. When two Cysteines are next to each other they G, S, T, N, Q, Y attract and form a strong bond. These strong bonds contribute to protein shape White = cystine formation. C Learning Set 4 : Lesson 2 : Slide 12
  21. 21. Sickle Cell Hemoglobins Stick Together Learning Set 4 : Lesson 2 : Slide 13
  22. 22. Electrophoresis of Sickling and Non Sickling Hemoglobin Learning Set 4 : Lesson 2 : Slide 14
  23. 23. Effects of Sickle Cell Mutation DNA order ofL T P E E K S L T P V E K S amino acids protein shape cell function Learning Set 4 : Lesson 2 : Slide 14
  24. 24. Passing on Mutations Learning Set 4 : Lesson 3 : Slide 16
  25. 25. Frequency of Sickle Cell Causing Mutationvs. Frequency of Malaria Causing Microbe http://www.pbs.org/wgbh/evolution/library/01/2/l_012_02.html Learning Set 4 : Lesson 4 : Slide 17
  26. 26. Analyzing RNA Using Gel Electrophoresis Learning Set 4 : Lesson 5 : Slide 18
  27. 27. Who has lactose intolerance in Jason’s family? Learning Set 4 : Lesson 5 : Slide 19
  28. 28. DNA Sequence Analysis of Lactase Protein Gene Learning Set 4 : Lesson 5 : Slide 20
  29. 29. Gel Electrophoresis: Lactase Protein Samples from Jason’s Family Learning Set 4 : Lesson 5 : Slide 21
  30. 30. RNA Analysis of Lactase Protein Gene Learning Set 4 : Lesson 5 : Slide 22
  31. 31. DNA Sequence of Area Near the Lactase Gene Learning Set 4 : Lesson 5 : Slide 23

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