Organic synthesis the disconnection approach by stuart warren
The Disconnection Approach
Schoolof of Bristol , U瓦
AJohn 飞iVìley and Sons, Ltd" Publication
This edition first published 2008
2008 John 飞的 ley & Sons , Inc.
John 皆iley & Sons Ltd， τhe Atrium , Southem Gate. Chichester，有部 t Suss帜， P019 8S龟 United Kingdom
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LibraηI 0/ Congress C.αtaloging-in-Pl￥blication Data
Warren哩 Stuart G.
Organic synthesís : the disconnection approach I Stuart Warren and Paul Wyatt.一一 2nd ed.
Includes biblíographical references and index.
ISBN 978-0-470-71237-5 (cloth)一-ISBN 978-0斗70-71236-8 (pbk. :
1. O~mic L 百yatt， PauL n. 在tle.
A catalogue record for this book is available from the British
ISl日-l' 978-0-470-7份 12375 (HIB) 978-0-470平 12368 (P!B)
τypeset in 10/12 Times-Roman by Laserwords Private Li mited , Chennai , India
Printed and bound in Great Britain by CPI Antony Rowe, Chippenham, Wiltshire
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General References XI
2. Basic and Synthesis of Aromatic
3. Strategy 1: The Order of Events
4. One-Group C-X Dìsconnections
5. Strate 2: v II:
6. C-X DisconnectÎ ons
7. III: Reversal of Polarity , 4a of
生 Strategy IV: Protecting
10. One Group C C Disconnections 1: Alcohols
11. General St栩如前r A: a Disconnection
12. Strate玄v V:
15. Alkene 1
16. Strategy VII: 盯se of (Alkynes) l
17.τwo-Group C…C Disconnections 1: Diels-Ald时 Reactions
18. Strate 2: v VIII: Introduction to
20. IX: Control in Car柱。nvl Condensations 1
21. C-C Disconnections III: Compounds
Conjugate (Michael) Addîtion and Robinson Annelation 151
22. X: 技itro 161
23. 在NφGroup Disconnections IV: Compounds 167
25. Disconnections V: 185
26. Strategy XII: Reconnection 193
27. Two-Group C…C Disconn巳ctions VI: 199
28. General B: Strategy of Car七onyl Disconnections 207
29. XIII: Introduction to Synthesis: Saturated 217
30. Three品lernbered 229
3 1. XIV: 237
33. XV:τhe Use of Ketenes in 251
34. Five-Mem如 ered 255
35. Strate Q. v XV I: Special Methods
36. Six-Membered Rings 269
37. General Strategy C: Synthesis 279
38. XVII: 289
39. AromatÍC 301
40. General D:A母 vanced 313
In the 26 years since 有iley publìshed Organic 1于ze Disconnection Approach 色y Stuart
Warren ，由自 approach to the learning of synthesis has become while the book Ìtself
is now dated in content and appearance ‘ In 唱Tiley published Organic
and Control by Paul Wyatt and Stuart 轧Tarren. Thís muc如柱。ok ís as a
fourth year und巳 rgradu时es and research workers in universities and industry. The
workbook was published ìn 2008.τ如is new book made thεold one look very dated ín
and content and gaps between what students were expectεd to understand in the 1980s
and what are to understand now. This second edition is intended to fill some of
The of the book is the same in the second edítion. It alternates chapters
new concepts wÌth strategy chapters that put 出e new work in the context of overall planning.
丁he 40 chapters have the same titles: some have hardly been changed whíle others
have a revision with considerable amounts of new m剖erial. In most cases
from recent years are included.
One source of new material is the courses 出at the authors in the pharmaceutical
Our 色asic course is 'The Disconnection Approach' and the 削aterial we have for this
course has reinforced our attempts to reasons for the of the various compounds
which we 忧 lieve enlivens the 加ok and makes it more for students. We to
a second edítíon of the workbook after the publication of the
The 民rst edition of th巳 textbook was in fact thεthird in a series of 品。oks on
by 乳 The firs t: The an lntroduction to
如 1974 ， is a book asking for a of interaction with the reader who
was to solve pro剖ems while rarely use now as the
method has 岳阳 n suplersedt~d 七 y interactive programmes on computers. Paul Wyatt is writín革 an
electronic book to replace The Cα rbonyl Group which will a of an electronic
七ook and 七ooks with associated workbooks in a uniform format that we hope will prove of
value as students of organic develop their careers.
Stuart 飞可arren and Paul 研rya生在