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2016 ROTARY INTERNATIONAL CONVENTION
RAGMSA
Rotarian Action Group of
Multiple Sclerosis Awareness
www.rotary-rfmsa.org
• The protective covering or insulation of
the nerve fibres (mylin) in the central
nervous system is damaged and thus nerv...
• Over 2 million people worldwide are
diagnosed with MS
• Multiple Sclerosis can be observed as early
as 2 years of age an...
• Ratio 3:1 women/men
• Mainly young women & men 17/40 years
• The further North & South of equator
higher incidence
Who D...
• Rotarians support in many ways
• MS Fundraisers
• Bike Rides, Mega Swims, Walks, Golf, etc
• MS Research PhD Scholarship...
Rotarians organizing events to Raise MS Awareness and Funds
Rotarians organising Events- MS Global Dinner
Rotarians Joining in MS Walks and Runs
Rotarians Cooking for MS Bike Rides, Walks, Runs
Rotarians organising Bike Rides
Rotarians at RAGMSA Booth
• Recent advances in Clinical Management
of Multiple Sclerosis
Introduce Ms Sun-Hyun Kim
2016 ROTARY INTERNATIONAL CONVENTION
Recent advances in management
of multiple sclerosis
Dr Su-Hyun Kim
Department of Neur...
What is multiple sclerosis?
Global prevalence of MS in 2013
Paul Browne et al. Neurology 2014;83:1022-1024
~2.5 Million people in the world
1,500~2,00...
• 2,3X more females are
diagnosed with MS
• MS is not contagious
or inherited
• Most people are
diagnosed between
the ages...
What causes MS?
• Immunologic factors
• Environmental factors
Vitamin D, smoking
• Infectious factors
EBV infection
• Gene...
Symptoms of MS
Anxiety
Cognitive impairment
Visual disturbance
Vertigo
Sleep disorders
Depression
Double vision
Fatigue Pa...
Clinical course of MS
Nat Rev Neurosci 2012;13:507-14
How is MS diagnosed?
Since there is no single test for MS, MS can be difficult to
diagnose.
Thoughtful
clinical
evaluation...
History of diagnostic criteria for MS
Other conditions to rule out
NMOMS
Proportion of NMO/MS
Western Asia
MS
NMO NMOMS
1:0.8~3
1:0.06~0.006
Curr Opin Neurol 2016;29:372-380
24
Why early?
Treatment initiated at different stages of MS can affect
outcomes
Disability
Time
Preclinical CIS RRMS SPMS
...
• Treating exacerbation
• Modifying disease course
• Managing symptoms
• Promoting function through rehabilitation
Treatin...
19901960 2000 2010
Corticosteroids
for acute
treatment
IFNβ-1b
(Betaseron®)
IFNβ-1a
(Rebif®)
Glatiramer
acetate
(Copaxone®...
Therapeutic options in Korea
Burden of Therapy
(Convenience, monitoring, tolerability, and safety)
Diseaseactivity
IFN
GA
...
Korean society of MS (From 2005)
Healthcare costs of people with MS
in Korea
 Average annual direct
medical cost for person
with MS in Korea
Journal of MS...
• Awareness about MS among general public
is still fairly low
• Insufficient eligible/certified neurologists,
physiatrists...
Take home message
• There is no cure, but MS is treatable disease.
• Our aims is to ensure that people living with MS
in K...
Thank you!
herena20@ncc.re.kr
Rate this session! Your feedback is valuable so remember to
complete the brief session evaluation in the convention
mobile...
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Kiss Goodbye to MS

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An estimated 2.3 million people live with multiple sclerosis
worldwide. This disease of the central nervous system is
unpredictable and is often first diagnosed between the
ages of 20 and 50, disrupting the lives of otherwise healthy
people. Learn how your Rotary club can work with the
Rotarian Action Group for Multiple Sclerosis Awareness
and local MS societies to fund research and to support
individuals living with the illness.

Published in: Government & Nonprofit
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Kiss Goodbye to MS

  1. 1. 2016 ROTARY INTERNATIONAL CONVENTION RAGMSA Rotarian Action Group of Multiple Sclerosis Awareness www.rotary-rfmsa.org
  2. 2. • The protective covering or insulation of the nerve fibres (mylin) in the central nervous system is damaged and thus nerve impulses to the brain, spine and optic nerve are short circuited. What is MS
  3. 3. • Over 2 million people worldwide are diagnosed with MS • Multiple Sclerosis can be observed as early as 2 years of age and becomes more frequent after age of 10 years. How Many People does MS affect?
  4. 4. • Ratio 3:1 women/men • Mainly young women & men 17/40 years • The further North & South of equator higher incidence Who Does MS Affect
  5. 5. • Rotarians support in many ways • MS Fundraisers • Bike Rides, Mega Swims, Walks, Golf, etc • MS Research PhD Scholarships • Health Fair participation • rotary-msawareness@yahoo groups.com How Do Rotarians Help?
  6. 6. Rotarians organizing events to Raise MS Awareness and Funds
  7. 7. Rotarians organising Events- MS Global Dinner
  8. 8. Rotarians Joining in MS Walks and Runs
  9. 9. Rotarians Cooking for MS Bike Rides, Walks, Runs
  10. 10. Rotarians organising Bike Rides
  11. 11. Rotarians at RAGMSA Booth
  12. 12. • Recent advances in Clinical Management of Multiple Sclerosis Introduce Ms Sun-Hyun Kim
  13. 13. 2016 ROTARY INTERNATIONAL CONVENTION Recent advances in management of multiple sclerosis Dr Su-Hyun Kim Department of Neurology, National Cancer Center
  14. 14. What is multiple sclerosis?
  15. 15. Global prevalence of MS in 2013 Paul Browne et al. Neurology 2014;83:1022-1024 ~2.5 Million people in the world 1,500~2,000 people in Korea
  16. 16. • 2,3X more females are diagnosed with MS • MS is not contagious or inherited • Most people are diagnosed between the ages of 20 and 50. What gets MS? 20 40 50 60301051
  17. 17. What causes MS? • Immunologic factors • Environmental factors Vitamin D, smoking • Infectious factors EBV infection • Genetic factors HLA-DRB1501, HLA-DRB0901 genotype
  18. 18. Symptoms of MS Anxiety Cognitive impairment Visual disturbance Vertigo Sleep disorders Depression Double vision Fatigue Pain Impaired speech Sexual problems Poor balance Bladder problems Tremor Stiffness Clumsiness Bowel problems Weakness Numbness
  19. 19. Clinical course of MS Nat Rev Neurosci 2012;13:507-14
  20. 20. How is MS diagnosed? Since there is no single test for MS, MS can be difficult to diagnose. Thoughtful clinical evaluation Complete Assessment for excluding other MS mimic diseases Proper interpretation of MRI Diagnosis of MS
  21. 21. History of diagnostic criteria for MS
  22. 22. Other conditions to rule out NMOMS
  23. 23. Proportion of NMO/MS Western Asia MS NMO NMOMS 1:0.8~3 1:0.06~0.006 Curr Opin Neurol 2016;29:372-380
  24. 24. 24 Why early? Treatment initiated at different stages of MS can affect outcomes Disability Time Preclinical CIS RRMS SPMS Clinical Threshold Treatment of RRMS Treatment after a first event Treatment of SPMS OPTIMAL THERA- PEUTIC WINDOW
  25. 25. • Treating exacerbation • Modifying disease course • Managing symptoms • Promoting function through rehabilitation Treating MS
  26. 26. 19901960 2000 2010 Corticosteroids for acute treatment IFNβ-1b (Betaseron®) IFNβ-1a (Rebif®) Glatiramer acetate (Copaxone®) IFNβ-1a (Avonex®) FDA 1993 FDA 2002 FDA 1996 FDA 1996 Mitoxantrone (Novantrone®) FDA 2000 Natalizumab (Tisabri®) FDA 2006 Fingolimod (Gilenya®) Dimethyl fumarate (TAC ) Teriflunomide (Aubagio®) FDA 2013 FDA 2010 FDA 2012 Aelmtuzumab (Lemtrada®) FDA 2014 PegIFN β-1a (Plegridy®) FDA 2014 11 Licensed Treatments for people with MS
  27. 27. Therapeutic options in Korea Burden of Therapy (Convenience, monitoring, tolerability, and safety) Diseaseactivity IFN GA Teriflun omide Fingolimod BG-12 Nataliz umab Mitoxa ntrone Alemtu zumab
  28. 28. Korean society of MS (From 2005)
  29. 29. Healthcare costs of people with MS in Korea  Average annual direct medical cost for person with MS in Korea Journal of MS 2015;6:9-13 0% 10% 20% 30% 40% 50% 60% 70% EDSS <4 4≤EDSS<6.5 EDSS≥6.5 $0 $10,000 $20,000 $30,000 $40,000 $50,000 EDSS <4 4≤EDSS<6.5 EDSS≥6.5 Employment rate according to The level of disability Medical costs according to the level of disability
  30. 30. • Awareness about MS among general public is still fairly low • Insufficient eligible/certified neurologists, physiatrists or nurses in specialized clinical care of MS. • Lack of social care services, educational program, financial assistance program Unmet needs of people with MS and their cares in Korea
  31. 31. Take home message • There is no cure, but MS is treatable disease. • Our aims is to ensure that people living with MS in Korea have the best quality of evidence based care and treatment that health and social care systems • To get the best results and benefits for people with MS, it is important for health and social care providers, research and industry to work together
  32. 32. Thank you! herena20@ncc.re.kr
  33. 33. Rate this session! Your feedback is valuable so remember to complete the brief session evaluation in the convention mobile app. To download the app, search for “Rotary Events” in your Apple or Android app store. This presentation and others from throughout the convention are available through the convention mobile app and on SlideShare at www.SlideShare.net/Rotary_International.

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